Page 93 - 《中国药房》2023年11期

不同商品规格等级党参药材的质量分析
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张小慧 ，仝立国 ，王亦冰 ，李志强 ，席啸虎 ，王 爽 ，王世伟 （1.山西省中医药研究院中心实验室，太原
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030012；2.长治医学院药学系，山西 长治 046013；3.山西省中医院药剂科，太原 030012）
中图分类号 R917；R282 文献标志码 A 文章编号 1001-0408（2023）11-1363-05
DOI 10.6039/j.issn.1001-0408.2023.11.15
摘 要 目的 研究不同商品规格等级党参药材的质量，为该药材的市场流通、科研及临床使用提供依据。方法 根据目前党参药
材的商品规格等级划分标准，收集不同产地、基原、商品规格等级的党参药材共17批，采用高效液相色谱法测定党参苷Ⅰ、党参炔
苷和白术内酯Ⅲ的含量，采用《中国药典》（四部）中醇溶性浸出物测定法（通则2201）项下“热浸法”测定其醇溶性浸出物的含量，
采用苯酚硫酸法测定其多糖的含量（以D-无水葡萄糖计）。结果 对于党参的栽培品种，4种规格3个商品等级的党参药材均含有
党参苷Ⅰ和党参炔苷，潞党参、纹党参还含有白术内酯Ⅲ。党参苷Ⅰ、党参炔苷、白术内酯Ⅲ含量方面，栽培药材二等品与一等品
含量相当，甚至优于一等品，三等品含量低于一等品、二等品；两种野生党参中党参苷Ⅰ含量最高。醇溶性浸出物和多糖含量方
面，栽培药材一等品含量高于二等品，二等品含量高于三等品，野生党参含量较低。结论 不同商品规格等级的党参药材栽培品种
的内在质量和目前依据性状和基原的规格等级划分标准基本一致，一等药材与二等药材均有较高的指标成分含量，属优质药材。
关键词 党参；商品规格等级；党参苷Ⅰ；党参炔苷；白术内酯Ⅲ；多糖；质量评价

Quality analysis of Codonopsis pilosula with different commodity specification grades
ZHANG Xiaohui ，TONG Liguo ，WANG Yibing ，LI Zhiqiang ，XI Xiaohu ，WANG Shuang ，WANG Shiwei 3
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（1. Central Laboratory， Shanxi Academy of Traditional Chinese Medicine， Taiyuan 030012， China；2. Dept. of
Pharmacy， Changzhi Medical College， Shanxi Changzhi 046013， China；3. Dept. of Pharmacy， Shanxi Hospital
of Traditional Chinese Medicine， Taiyuan 030012， China）
ABSTRACT OBJECTIVE To study the quality of Codonopsis pilosula with different commodity specification grades， and to
provide the data support for market transactions， scientific research and clinical use. METHODS According to the classification
standard of commodity specification grades of C. pilosula， 17 batches of C. pilosula from different producing areas， origins and
commodity specification grades were collected. The contents of tangshenoside Ⅰ， lobetyolin and atractylenolide Ⅲ were determined
by HPLC. The contents of alcohol-soluble extracts were determined by hot dipping method stated in general rule 2201 of Chinese
Pharmacopeia （part Ⅳ）. The contents of polysaccharide were determined by phenol-sulfuric acid method （calculated by D-glucose
anhydrous）. RESULTS For cultivar of C. pilosula， four specifications and three commodity grades of C. pilosula all contained
tangshenoside Ⅰ and lobetyolin； Radix C. pilosula from Shanxi of China and C. pilosula from Wenxian County of China， also
contained atractylenolide Ⅲ. In terms of the contents of tangshenoside Ⅰ， lobetyolin and atractylenolide Ⅲ， the content of second
class was equivalent to that of first class， even better than the first class， while the content of third class was lower than that of
first class and second class； the content of tangshenoside Ⅰ was the highest among the two types of wild C. pilosula. The contents
of alcohol-soluble extracts and polysaccharides in first class cultivated C. pilosula were higher than those of second class， and the
second class was higher than the third class； wild C. pilosula had low content of alcohol-soluble extracts and polysaccharides.
CONCLUSIONS The internal quality of C. pilosula is basically consistent with the classification standard of different commodity
specification grades； the content of each indicator in first-class and second-class medicinal herb is high， making them high-quality
medicinal herbs.
Δ 基金项目 山西省卫生健康委科研课题（No.2018085）；山西省 KEYWORDS Codonopsis pilosula； commodity specification
卫生健康委员会“四个一批”科技兴医创新计划项目（No.2020SYS06）
grade； tangshenoside Ⅰ ； lobetyolin； atractylenolide Ⅲ ；
＊第一作者 副主任药师。研究方向：中药材、中药饮片鉴定及质
量研究。E-mail：562390325@qq.com polysaccharide； quality evaluation
# 通信作者 主任药师。研究方向：中药质量评价。E-mail：
78971507@qq.com

中国药房 2023年第34卷第11期 China Pharmacy 2023 Vol. 34 No. 11 · 1363 ·