Page 133 - 《中国药房》2023年8期

ploratory phase Ⅱ trial of oral itraconazole for the treat‐ hibitor for the treatment of hematological malignancies[J].
ment of basal cell carcinoma[J]. J Clin Oncol，2014，32 Anticancer Drugs，2018，29（10）：995-1003.
（8）：745-751. [47] INFANTE P，ALFONSI R，INGALLINA C，et al. Inhibi‐
[35] KELLY R J，ANSARI A M，MIYASHITA T，et al. Targe- tion of hedgehog-dependent tumors and cancer stem cells
ting the hedgehog pathway using itraconazole to prevent by a newly identified naturally occurring chemotype[J].
progression of barrett’s esophagus to invasive esophageal Cell Death Dis，2016，7（9）：e2376.
adenocarcinoma[J]. Ann Surg，2021，273（6）：e206-e213. [48] ALFONSI R，BOTTA B，CACCHI S，et al. Design，
[36] MILLER-MOSLIN K，PEUKERT S，JAIN R K，et al. palladium-catalyzed synthesis，and biological investiga‐
1-amino-4-benzylphthalazines as orally bioavailable smoo- tion of 2-substituted 3-aroylquinolin-4（1H）-ones as in‐
thened antagonists with antitumor activity[J]. J Med hibitors of the hedgehog signaling pathway[J]. J Med
Chem，2009，52（13）：3954-3968. Chem，2017，60（4）：1469-1477.
[37] PEUKERT S，HE F，DAI M，et al. Discovery of NVP- [49] SCHAEFER G I，PEREZ J R，DUVALL J R，et al. Disco-
LEQ506，a second-generation inhibitor of smoothened[J]. very of small-molecule modulators of the Sonic hedgehog
ChemMedChem，2013，8（8）：1261-1265. pathway[J]. J Am Chem Soc，2013，135（26）：9675-9680.
[38] JIN G H，SIVARAMAN A，LEE K. Development of tala‐ [50] SOLINAS A，FAURE H，ROUDAUT H，et al. Acyl-
degib as a sonic hedgehog signaling pathway inhibitor[J]. thiourea，acylurea，and acylguanidine derivatives with
Arch Pharm Res，2017，40（12）：1390-1393. potent hedgehog inhibiting activity[J]. J Med Chem，2012，
[39] OAK A S W，BOCHEVA G，KIM T K，et al. Noncalcemic 55（4）：1559-1571.
vitamin D hydroxyderivatives inhibit human oral squa‐ [51] AGYEMAN A，JHA B K，MAZUMDAR T，et al. Mode
mous cell carcinoma and down-regulate hedgehog and and specificity of binding of the small molecule GANT61
WNT/β -catenin pathways[J]. Anticancer Res，2020，40 to GLI determines inhibition of GLI-DNA binding[J]. On‐
（5）：2467-2474. cotarget，2014，5（12）：4492-4503.
[40] TANG J Y，XIAO T Z，ODA Y，et al. Vitamin D3 inhibits [52] GOLDMAN J，ECKHARDT S G，BORAD M J，et al.
hedgehog signaling and proliferation in murine Basal cell Phase I dose-escalation trial of the oral investigational
carcinomas[J]. Cancer Prev Res （Phila），2011，4（5）： hedgehog signaling pathway inhibitor TAK-441 in pa‐
744-751. tients with advanced solid tumors[J]. Clin Cancer Res，
[41] DEBERARDINIS A M，RACCUIA D S，THOMPSON E 2015，21（5）：1002-1009.
N，et al. Vitamin D3 analogues that contain modified A- [53] BOSCO-CLÉMENT G，ZHANG F，CHEN Z，et al. Tar‐
and seco-B-rings as hedgehog pathway inhibitors[J]. Eur J geting Gli transcription activation by small molecule sup‐
Med Chem，2015，93：156-171. presses tumor growth[J]. Oncogene，2014，33（16）：2087-
[42] BANERJEE U，DEBERARDINIS A M，HADDEN M K. 2097.
Design，synthesis，and evaluation of hybrid vitamin [54] BEAUCHAMP E M，RINGER L，BULUT G，et al. Arse‐
D3 side chain analogues as hedgehog pathway inhibitors nic trioxide inhibits human cancer cell growth and tumor
[J]. Bioorg Med Chem，2015，23（3）：548-555. development in mice by blocking hedgehog/Gli pathway
[43] MASCHINOT C A，HADDEN M K. Synthesis and eva- [J]. J Clin Invest，2011，121（1）：148-160.
luation of vitamin D3 analogues with C-11 modifications [55] LI B，FEI D L，FLAVENY C A，et al. Pyrvinium atte-
as inhibitors of hedgehog signaling[J]. Bioorg Med Chem nuates hedgehog signaling downstream of smoothened[J].
Lett，2017，27（17）：4011-4014. Cancer Res，2014，74（17）：4811-4821.
[44] 赵伟利，董肖椿，陆秀宏，等. 吡唑酞嗪化合物及其制备 [56] DIDIASOVA M，SINGH R，WILHELM J，et al. Pirfeni‐
方法和用途：CN105985321B[P]. 2018-10-26. done exerts antifibrotic effects through inhibition of Gli
[45] HOCH L，FAURE H，ROUDAUT H，et al. MRT-92 inhi- transcription factors[J]. FASEB J，2017，31（5）：1916-
bits hedgehog signaling by blocking overlapping binding 1928.
sites in the transmembrane domain of the smoothened （收稿日期：2022-09-13 修回日期：2023-02-12）
receptor[J]. FASEB J，2015，29（5）：1817-1829. （编辑：孙 冰）
[46] LIN P，HE Y M，CHEN G D，et al. A novel hedgehog in‐

中国药房 2023年第34卷第8期 China Pharmacy 2023 Vol. 34 No. 8 · 1019 ·