Page 111 - 《中国药房》2022年18期
P. 111

·药师与药学服务·


          临床药师参与 1 例椎间神经鞘瘤切除术后脓肿分枝杆菌感染的

          药学监护          Δ



                                           1
                          1
                                                   1 #
          吴燕燕   1,2* ,王 璨 ,杨昕炜 ,孔文强 ,胡雪莲 (1.陆军军医大学第二附属医院药学部,重庆 400037;2.重庆
                                   1
          市妇幼保健院/重庆医科大学附属妇女儿童医院药学部,重庆 401147)
          中图分类号 R978.3         文献标志码 A          文章编号     1001-0408(2022)18-2277-04
          DOI  10.6039/j.issn.1001-0408.2022.18.20


          摘  要 目的 为治疗脓肿分枝杆菌感染的药学监护提供思路。方法 对临床药师参与的1例椎间神经鞘瘤切除术后脓肿分枝杆
          菌感染患者的诊疗方案进行分析。临床药师根据创口分泌物细菌培养及药敏试验结果,及时处理治疗过程中出现的药物不良反
          应,针对患者服用阿米卡星(0.4 g,静脉滴注,q12 h)后引起的耳鸣,建议停用阿米卡星,改为利奈唑胺,但该患者在服用利奈唑胺
          后出现膝关节痛,临床药师再次建议停用利奈唑胺,继续使用阿米卡星,并将剂量调整为0.8 g,静脉滴注,q24 h;同时对患者进行
          用药指导并嘱患者出院后定期复查随访。结果 临床医师采纳了临床药师的建议,该患者未再出现耳鸣、膝关节痛等不适,肝肾功
          能也无异常。结论 临床药师及时协助临床医师调整用药方案,提高了患者用药的有效性和安全性。
          关键词 临床药师;脓肿分枝杆菌;皮肤;软组织;感染;不良反应;药学监护


          Participation of clinical pharmacists in pharmaceutical care for a patient with Mycobacterium abscess
          infection after the resection of intervertebral schwannoma
                                                                   1
                                                 1
                                  1
                    1,2
                                                                               1
          WU Yanyan ,WANG Can ,YANG Xinwei ,KONG Wenqiang ,HU Xuelian(1. Dept. of Pharmacy,Second
          Affiliated Hospital,Army Medical University,Chongqing 400037,China;2. Dept. of Pharmacy,Chongqing
          Health Center for Women and Children/Women and Children’s Hospital of Chongqing Medical University,
          Chongqing 401147,China)
          ABSTRACT    OBJECTIVE To provide ideas for pharmaceutical care of Mycobacterium abscess infection. METHODS The
          diagnosis and treatment plan,about a patient with M. abscess infection after resection of intervertebral neurilemmoma participated
          by clinical pharmacists,was analyzed. According to the results of bacterial culture and drug sensitivity test of wound secretion,the
          clinical pharmacist timely dealed with the adverse drug reactions during the treatment. For the tinnitus caused by the patient taking
          amikacin(0.4 g,intravenous drip,q12 h),it was suggested to stop amikacin and replace it with linezolid;however,the patient
          suffered from knee pain after taking linezolid. The clinical pharmacist once again suggested stopping linezolid,continuing to use
          amikacin,and adjusting the dose to 0.8 g,intravenous drip,q24 h;at the same time,the patients were given medication guidance
          and ordered to have regular follow-up after discharge. RESULTS The physicians adopted the suggestions of clinical pharmacists,
          and the patient did not suffer from tinnitus,knee pain and other discomfort,and the liver and kidney functions were normal.
          CONCLUSIONS Clinical pharmacists timely assist clinicians to adjust the medication plan,which improves the effectiveness and
          safety of patients’medication.
          KEYWORDS clinical pharmacist;Mycobacterium abscess;skin;soft tissue;infection;ADR;pharmaceutical care



             Δ 基金项目 重庆市临床药学重点专科建设项目;重庆市科卫联                       脓肿分枝杆菌 Mycobacterium abscess 是一种非结
          合医学科研项目(No.2021MSXM255)                            核分枝杆菌(nontuberculous mycobacteria),生长迅速,在
             *第一作者 主管药师,硕士。研究方向:抗感染临床药学。电话:                  水、土壤中广泛存在,可侵犯人体的多个系统,包括肺、
          023-60354332。E-mail:271206049@qq.com
                                                                                         [1]
                                                             骨骼、关节、皮肤及软组织等器官 。由于该菌对多数抗
             # 通信作者 副主任药师,博士。研究方向:抗感染临床药学。电
          话:023-68755407。E-mail:2840359613@qq.com            结核药物天然耐药或者获得性耐药,因此相关指南建议

          中国药房    2022年第33卷第18期                                            China Pharmacy 2022 Vol. 33 No. 18  ·2277·
   106   107   108   109   110   111   112   113   114   115   116