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3 结语 [11] ZONGO I，COMPAORÉ Y D，NIKIÉMA F，et al. Efficacy
ACT 的临床治疗效果良好，已经成为了 WHO 推荐 of artemether-lumefantrine and artesunate-amodiaquine
的抗疟标准疗法。但目前存在疟原虫对其产生耐药性 as first line therapy of uncomplicated malaria in Burkina
等问题，这给 ACT 的应用带来了挑战。针对此问题，可 Faso，11 years after policy change[J]. Pan Afr Med J，
2020，35：68.
以更换ACT中已产生耐药性的长效辅助抗疟药物；或者
[12] TOURE O A，LANDRY T N，ASSI S B，et al. Malaria para-
适当延长用药时间，由通常的3日疗法增至5日或7日；
site clearance from patients following artemisinin-based
或者采用 TACT，以达到更好的治疗效果。已有文献报
combination therapy in Côte d’Ivoire[J]. Infect Drug Re-
道，AL（5 日疗法）在缅甸的治疗效果和患者耐受性良
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[58]
好，并能有效延长该治疗方案的使用寿命 。此外，疟 [13] TOURE O A，ASSI S B，KIKI-BARRO P M C，et al. Effi-
原虫对青蒿素的耐药性还会影响许多细胞靶点，而针对 cacy and safety of artesuante-amodiaquine and artemether
已知靶点开发新药也是解决该类药物耐药性的一种有 lumefantrine，the first line malaria treatment in six sentinel’s
效途径 。综上，加强对 ACT 中抗疟药物的研发，深入 sites of Côte d’Ivoire，West Africa[J]. Ann Parasitol，2020，
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方法将是今后抗疟工作的重点。 [14] NDONG NGOMO J M，ONDZAGHA MEGNIE G J，
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·1908 · China Pharmacy 2022 Vol. 33 No. 15 中国药房 2022年第33卷第15期