Page 70 - 《中国药房》2021年第9期

[11] SALEH S，EL-MARAGHY N，REDA E，et al. Modula- deficiency leads to Alzheimer’s disease-like cognitive im-
tion of diabetes and dyslipidemia in diabetic insulin-resis- pairments and pathologies through AMPK inactivation
tant rats by mangiferin：role of adiponectin and TNF-α[J]. and cerebral insulin resistance in aged mice[J]. Mol Neu-
An Acad Bras Cienc，2014，86（4）：1935-1948. rodegener，2016，2016，11（1）：71.
[12] ZHU X，YAN H，XIA M，et al. Metformin attenuates tri- [24] LIAN K，GUO X，HUANG Q，et al. Reduction levels and
glyceride accumulation in HepG2 cells through decrea- the effects of high-molecular-weight adiponectin via
sing stearyl-coenzyme A desaturase 1 expression[J]. Lipids AMPK/eNOS in Chinese type 2 diabetes[J]. Exp Clin En-
Health Dis，2018，17（1）：114. docrinol Diabetes，2016，124（9）：541-547.
[13] 金惠杰，邱昆成，李嘉华，等.药对知母-黄柏对胰岛素抵 [25] LÓPEZ-BERMEJO A，BOTAS-CERVERO P，ORTEGA-
抗的改善作用[J].中国药理学通报，2019，35（7）：1020- DELGADO F，et al. Association of ADIPOR2 with liver
1024. function tests in type 2 diabetic subjects[J]. Obesity（Sil-
[14] ZHENG T，SHU G，YANG Z，et al. Antidiabetic effect of ver Spring），2008，16（10）：2308-2313.
total saponins from Entada phaseoloides （L.） Merr. in [26] WANG Y，ZHANG M，YAN L，et al. Serum APPL1 level
type 2 diabetic rats[J]. J Ethnopharmacol，2012，139（3）： is elevated in newly diagnosed cases of type 2 diabetes
814-821. mellitus[J]. Nan Fang Yi Ke Da Xue Xue Bao，2012，32
[15] LI L，LI G，WEI H，et al. The endoplasmic reticulum （9）：1373-1376.
stress response is associated with insulin resistance-me- [27] YANAI H，YOSHIDA H. Beneficial effects of adiponectin
diated drug resistance in HepG2 cells[J]. Neoplasma， on glucose and lipid metabolism and atherosclerotic pro-
2015，62（2）：180-190. gressio，2019，20（5）：1190.
[16] YADAV A，KATARIA M A，SAINI V，et al. Role of leptin [28] BOUCHER J，KLEINRIDDERS A，KAHN C R. Insulin
and adiponectin in insulin resistance[J]. Clin Chim Acta， receptor signaling in normal and insulin-resistant states[J].
2013，18：80-84. Cold Spring Harb Perspect Biol，2014，6（1）：a009191.
[17] DASKALOPOULOS E P，DUFEYS C，BERTRAND L， [29] TIAN S，JIA W，LU M，et al. Dual-specificity tyrosine
et al. AMPK in cardiac fibrosis and repair：actions beyond phosphorylation-regulated kinase 1A ameliorates insulin
metabolic regulation[J]. J Mol Cell Cardiol，2016，91： resistance in neurons by up-regulating IRS-1 expres-
188-200. sion[J]. J Biol Chem，2019，294（52）：20164-20176.
[18] CHELLAPPAN D K，YAP W S，BT AHMAD SUHAIMI [30] REHMAN K，AKASH M S H，LIAQAT A，et al. Role of
N A，et al. Current therapies and targets for type 2 diabe- interleukin-6 in development of insulin resistance and
tes mellitus[J]. Panminerva Med，2018，60（3）：117-131. type 2 diabetes mellitus[J]. Crit Rev Eukaryot Gene Expr，
[19] DZIUBAK A，WÓJCICKA G，WOJTAK A，et al. Metabo- 2017，27（3）：229-236.
lic effects of metformin in the failing heart[J]. Int J Mol [31] CAO Y，SUN W. Fuzhu jiangtang granules combined with
Sci，2018，19（10）：2869. metformin reduces insulin-resistance in skeletal muscle of
[20] ZHANG Y，LIU X，HAN L，et al. Regulation of lipid and diabetic rats via PI3K/Akt signaling[J]. Pharm Biol，2019，
glucose homeostasis by mango tree leaf extract is media- 57（1）：660-668.
ted by AMPK and PI3K/AKT signaling pathways[J]. [32] KONG D，SONG G，WANG C，et al. Overexpression of
Food Chem，2013，141（3）：2896-2905. mitofusin 2 improves translocation of glucose transporter
[21] LI J，LIU M，YU H，et al. Mangiferin improves hepatic li- 4 in skeletal muscle of high fat diet fed rats through
pid metabolism mainly through its metabolite-norathyriol AMP activated protein kinase signaling[J]. Mol Med
by modulating SIRT-1/AMPK/SREBP-1c signaling[J]. Rep，2013，8（1）：205-210.
Front Pharmacol，2018，9：201. [33] 孙维琦，王路红，李环. AMPK 细胞能量感受器研究进
[22] KRAUSE M P，MILNE K J，HAWKE T J. Adiponectin- 展[J].北华大学学报（自然科学版），2017，18（2）：213-
consideration for its role in skeletal muscle health[J]. Int J 216.
Mol Sci，2019，20（7）：1528. （收稿日期：2020-11-05 修回日期：2021-02-25）
[23] NG RC，CHENG OY，JIAN M，et al. Chronic adiponectin （编辑：张元媛）

·1088 · China Pharmacy 2021 Vol. 32 No. 9 中国药房 2021年第32卷第9期