Page 47 - 《中国药房》2021年第6期
P. 47
式、保留时间并结合一级、二级质谱信息,共鉴定出 [11] TAO JH,ZHAO M,WANG DG,et al. UPLC-Q-TOF/
THSG的20个代谢产物,推测该化合物在大鼠体内的代 MS-based screening and identification of two major bio-
谢途径主要涉及葡萄糖水解、加氢、羟化、葡萄糖醛酸结 active components and their metabolites in normal and
合、硫酸化反应等,为进一步研究 THSG 的代谢产物以 CKD rat plasma,urine and feces after oral administration
及作用机制提供了重要信息。 of Rehmannia glutinosa Libosch extract[J]. J Chromatogr
参考文献 Biomed Appl,2015,1001:98-106.
[12] HUANG J,ZHANG JP,BAI JQ,et al. Chemical profiles
[ 1 ] 陈冰冰,姜爱玲,张岩.何首乌有效成分二苯乙烯苷的药
and metabolite study of raw and processed polygoni multi-
理活性研究进展[J].中国临床药理学与治疗学,2016,21
n
(6):710-715. flori radix in rats by UPLC-LTQ-Orbitrap MS spectrome-
[ 2 ] WANG XM,ZHAO LB,HAN TZ,et al. Protective effects try[J]. Chin J Nat Med,2018,16(5):375-400.
of 2,3,5,4′-tetrahydroxystilbene -2-O-β-D-glucoside,an [13] ZHANG J,GUO Q,WEI M,et al. Metabolite identifica-
active component of Polygonum multiflorum Thunb,on tion and pharmacokinetic profiling of isoflavones from
experimental colitis in mice[J]. Eur J Pharmacol,2008, black soybean in rats using ultrahigh-performance liquid
578(2/3):339-348. chromatography with linear-ion-trap-orbitrap and triple-
[ 3 ] CHEUNG FW,LEUNG AW,LIU WK,et al. Tyrosinase quadrupole tandem mass spectrometry[J]. J Agric Food
inhibitory activity of a glucosylated hydroxystilbene in Chem,2018,66(49):12941-12952.
mouse melan:a melanocytes[J]. J Nat Prod,2014,77(6): [14] 徐文.液质联用技术在两种中药成分分析中的应用[D].
1270-1274. 广州:广州中医药大学,2015.
[ 4 ] SANDOR R,MIDLIK A,SEBRLOVA K,et al. Identifica- [15] LIN LF,LIN HM,YIN XB,et al. Characterization of the
tion of metabolites of selected benzophenanthridine alka- constituents in rat plasma after oral administration of ra-
loids and their toxicity evaluation[J]. J Pharm Biomed dix polygoni multiflori extracts by ultra-performance li-
Anal,2016,121:174-180. quid chromatography/quadrupole time-of-flight mass spec-
[ 5 ] BUCK A,LY A,BALLUFF B,et al. High-resolution trometry[J]. Biomed Chromatogr,2015,29(10):1541-
MALDIFT-ICR MS imaging for the analysis of metabo- 1547.
lites from formalinfixed,paraffin-embedded clinical tissue [16] 郭忠会,贾志鑫,陈奎奎,等.基于UPLC-Q-TOF-MS分析
samples[J]. J Pathol,2015,237(1):123-132. 何首乌提取物体内外成分[J].中国中药杂志,2018,43
[ 6 ] WANG GW,BAO B,HAN ZQ,et al. Metabolic profile of (13):2796-2805.
fructus gardeniae in human plasma and urine using ultra [17] 刘震,徐风,王静哲,等.哈巴苷在大鼠体内代谢产物的鉴
high-performance liquid chromatography coupled with
定与分析[J].中国药房,2017,28(10):1310-1315.
high-resolution LTQ-orbitrap mass spectrometry[J]. Xeno-
[18] 张亚洲,王涛,邹树良,等.芹菜素在大鼠体内代谢产物的
biotica,2016,46(10):901-912.
鉴定与分析[J].中国药房,2016,27(4):479-482.
[ 7 ] 赵文靖,黄漠然,尚展鹏,等.丹参酮Ⅰ和丹参酮Ⅱ A在大
[19] BUENZ EJ. Aloin induces apoptosis in Jurkat cells[J].
鼠体内的代谢物研究[J].中国中药杂志,2018,43(1):
Toxicol In Vitro,2008,22(2):422-429.
174-182.
[20] 徐叶.雷公藤甲素及其衍生物雷腾舒药物代谢研究[D].
[ 8 ] 侯艳婷,王晓明,张家伟,等.高分辨质谱数据MDF技术
北京:中国科学院大学,2019.
的进展[J].天津中医药,2016,33(12):765-768.
[21] 林佩,陆建美,张光远,等.何首乌活性成分在肝 L-02 细
[ 9 ] MA SG,ZHU MS. Recent advances in applications of li-
胞中吸收及代谢产物的LC-MS/MS定性分析[J].中国药
quid chromatography-tandem mass spectrometry to the
学杂志,2015,50(12):1048-1053.
analysis of reactive drug metabolites[J]. Chem Biol Inter-
[22] 刘洁,李月婷,陈奕君,等.高分辨质谱数据处理策略在中
act,2009,179(1):25-37.
药体内外成分检测和表征中的应用进展[J].药学学报,
[10] XING J,ZANG M,ZHANG H,et al. The application of
2021,56(1):113-129.
high-resolution mass spectrometrybased data-mining tools
(收稿日期:2020-11-11 修回日期:2021-02-01)
in tandem to metabolite profiling of a triple drug combina-
(编辑:邹丽娟)
tion in humans[J]. Anal Chim Acta,2015,897:34-44.
中国药房 2021年第32卷第6期 China Pharmacy 2021 Vol. 32 No. 6 ·681 ·