Page 134 - 2019年11月第30卷第21期

我院新生儿口服片剂分剂量使用情况调查及对策分析 Δ

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彭 静 ，王 楹，杜兆松，徐 华（华中科技大学同济医学院附属武汉儿童医院/武汉市妇幼保健院药学部，武
汉 430016）

中图分类号 R969.3 文献标志码 A 文章编号 1001-0408（2019）21-3009-04
DOI 10.6039/j.issn.1001-0408.2019.21.25

摘 要 目的：调查我院新生儿科常需分剂量口服的片剂品种及使用频率，探讨片剂分剂量的可行性方案，为临床精准化、个性化
用药提供参考。方法：调取我院2017年7月1日－2018年11月30日新生儿内、外科住院患儿使用片剂品种的全部处方，分析各片
剂分剂量使用的频次，检索有关片剂分剂量的文献报道，对常需分剂量的口服片剂的溶解性、稳定性及推荐分法进行分析，并提出
建议。结果：本次调查共涉及常需分剂量的口服片剂有16个品种，共计分剂量达2 149频次。分剂量使用频次排前3名的品种分
别为维生素B2、左甲状腺素钠片、熊去氧胆酸片，占分剂量总频次的80.3％；经查阅文献后制订了分剂量方案的实施流程，并总结
了常用分剂量片剂的分劈方法，同时建议临床应通过综合评价片剂和患儿的特点来决定片剂分剂量方案。结论：片剂分剂量在我
院新生儿科临床普遍存在，本文总结的将片剂临时调配成口服液体型药品的方法可在必要时为药师提供参考，以满足临床个体化
的用药需求。
关键词 新生儿；口服片剂；分剂量；调查；文献
Investigation on Split Use of Oral Tablets in Neonates in Our Hospital and Analysis of Its Countermeasures
PENG Jing，WANG Ying，DU Zhaosong，XU Hua（Dept. of Pharmacy，Wuhan Children’s Hospital/Wuhan
Maternal and Child Healthcare Hospital， Tongji Medical College， Huazhong University of Science &
Technology，Wuhan 430016，China）

ABSTRACT OBJECTIVE：To investigate the variety and frequency of oral tablets splitting commonly used in pediatrics of
children’s hospital，and to explore the feasible scheme of tablet splitting，so as to provide the basis for clinical precision and
individuation of drug use. METHODS：From 1st Jul. 2017 to 30th Nov. 2018，all the prescriptions of tablet varieties used for
neonates hospitalized in internal and surgical departments in our hospital were obtained. The frequency of each tablet splitting was
analyzed，and the literature reports of the tablets splitting were searched. The solubility，stability and recommended method of oral
tablets splitting were analyzed，and the suggestion were made. RESULTS：In this study，there were 16 kinds of oral tablets that
often needed to be divided into different doses，with a total frequency of 2 149 times. Vitamin B2，Levothyroxine sodium tablets
and Ursodeoxycholic acid tablets ranked the top three in terms of dose splitting frequency，accounting for 80.3％ of the total dosing
cases. After consulting the literature，the implementation process of the dosage division scheme was formulated，and the splitting
methods of commonly used tablets were summarized. It is suggested that clinical evaluation of tablet and patient characteristics
should be taken to determine tablet dosing splitting plan. CONCLUSIONS：Tablet dosing splitting is common in neonatal
medication in our hospital. The methods of temporary dispensing tablet into oral liquid drugs summarized in this paper can provide

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Δ 基金项目：中国药学会全国医药经济信息网科技传播创新工程
2018年重点项目（No.CMEI2018KPYJ00106） anxious and depressive symptoms with medication nonad-
＊ 副 主 任 药 师 ，硕 士 。 研 究 方 向 ：临 床 药 学 。 电 话 ：027- herence in patients with stable coronary artery disease[J].
82433462。E-mail：pengjing2008@sina.com J Psychosom Res，2013，74（2）：122-127.
# 通信作者：主任药师。研究方向：医院药学。电话：027- （收稿日期：2019-05-28 修回日期：2019-09-01）
82433315。E-mail：1437060144qq.com （编辑：林 静）

中国药房 2019年第30卷第21期 China Pharmacy 2019 Vol. 30 No. 21 ·3009 ·