Page 138 - 《中国药房》2026年1期
P. 138
[ 9 ] LASRADO N,COLLIER A Y,MILLER J,et al. Waning plications[J]. Genes Cancer,2015,6(3/4):84-105.
immunity and IgG4 responses following bivalent mRNA [22] JEON Y,JO U,HONG J,et al. Trophoblast cell-surface
boosting[J]. Sci Adv,2024,10(8):eadj9945. antigen 2 (TROP2) expression in triple-negative breast
[10] SINGH S B. Discovery and development of dolastatin 10- cancer[J]. BMC Cancer,2022,22(1):1014.
derived antibody drug conjugate anticancer drugs[J]. J Nat [23] SANTI D V,CABEL L,BIDARD F C. Does sacituzumab-
Prod,2022,85(3):666-687. govitecan act as a conventional antibody drug conjugate
[11] LI F,EMMERTON K K,JONAS M,et al. Intracellular re‐ (ADC),a prodrug of SN-38 or both [J]. Ann Transl Med,
leased payload influences potency and bystander-killing 2021,9(14):1113.
effects of antibody-drug conjugates in preclinical models [24] BARDIA A,MAYER I A,VAHDAT L T,et al. Sacitu‐
[J]. Cancer Res,2016,76(9):2710-2719. zumab govitecan-hziy in refractory metastatic triple-
[12] KALINOVSKY D V, KHOLODENKO I V, negative breast cancer[J]. N Engl J Med,2019,380(8):
SVIRSHCHEVSKAYA E V,et al. Targeting GD2-positive 741-751.
tumor cells by pegylated scFv fragment-drug conjugates [25] BARDIA A,HURVITZ S A,TOLANEY S M,et al. Saci‐
carrying maytansinoids DM1 and DM4[J]. Curr Issues tuzumab govitecan in metastatic triple-negative breast can‐
Mol Biol,2023,45(10):8112-8125. cer[J]. N Engl J Med,2021,384(16):1529-1541.
[13] FU Z W,LI S J,HAN S F,et al. Antibody drug conjugate: [26] OKAJIMA D,YASUDA S,MAEJIMA T,et al. Datopota‐
the “biological missile” for targeted cancer therapy[J]. mab deruxtecan,a novel TROP2-directed antibody-drug
Signal Transduct Target Ther,2022,7:93. conjugate,demonstrates potent antitumor activity by effi‐
[14] JABBOUR E,PAUL S,KANTARJIAN H. The clinical de‐ cient drug delivery to tumor cells[J]. Mol Cancer Ther,
velopment of antibody-drug conjugates:lessons from leu‐ 2021,20(12):2329-2340.
kaemia[J]. Nat Rev Clin Oncol,2021,18(7):418-433. [27] SHIMIZU T,SANDS J,YOH K,et al. First-in-human,
[15] CRISCITIELLO C,CORTI C,DE LAURENTIIS M, phase Ⅰ dose-escalation and dose-expansion study of tro‐
et al. Tucatinib’s journey from clinical development to phoblast cell-surface antigen 2-directed antibody-drug
clinical practice:new horizons for HER-2-positive meta‐ conjugate datopotamab deruxtecan in non-small-cell lung
static disease and promising prospects for brain metastatic cancer:TROPION-PanTumor01[J]. J Clin Oncol,2023,41
spread[J]. Cancer Treat Rev,2023,120:102618. (29):4678-4687.
[16] TANG Y B,TANG F,YANG Y,et al. Real-time analysis [28] SCHMID P,WYSOCKI P J,MA C X,et al. 379MO:dato‐
on drug-antibody ratio of antibody-drug conjugates for potamab deruxtecan (Dato-DXd) + durvalumab (D) as
synthesis,process optimization,and quality control[J]. Sci first-line (1L) treatment for unresectable locally ad‐
Rep,2017,7(1):7763. vanced/metastatic triple-negative breast cancer (a/mT‐
[17] XU Z Y,GUO D D,JIANG Z L,et al. Novel HER-2-tar‐ NBC):updated results from BEGONIA,a phase Ⅰb/Ⅱ
geting antibody-drug conjugates of trastuzumab beyond T- study[J]. Ann Oncol,2023,34:S337.
DM1 in breast cancer:trastuzumab deruxtecan(DS- [29] CHENG Y Z,YUAN X X,TIAN Q,et al. Preclinical pro‐
8201a) and (vic-) trastuzumab duocarmazine (SYD985) files of SKB264,a novel anti-TROP2 antibody conjugated
[J]. Eur J Med Chem,2019,183:111682. to topoisomerase inhibitor,demonstrated promising antitu‐
[18] OGITANI Y,HAGIHARA K,OITATE M,et al. By‐ mor efficacy compared to IMMU-132[J]. Front Oncol,
stander killing effect of DS-8201a,a novel anti-human epi‐ 2022,12:951589.
dermal growth factor receptor 2 antibody-drug conjugate, [30] XU B H,YIN Y M,FAN Y,et al. Sacituzumab tirumote‐
in tumors with human epidermal growth factor receptor 2 can (SKB264/MK-2870) in patients (PTS) with pre-
heterogeneity[J]. Cancer Sci,2016,107(7):1039-1046. viously treated locally recurrent or metastatic triple-
[19] DIÉRAS V,DELUCHE E,LUSQUE A,et al. Abstract negative breast cancer (TNBC):results from the phase Ⅲ
PD8-02:trastuzumab deruxtecan (T-DXd) for advanced OptiTROP-Breast01 study[J]. J Clin Oncol,2024,42
breast cancer patients (ABC),regardless HER-2 status:a (Suppl. 16):104.
phase Ⅱ study with biomarkers analysis (DAISY)[J]. [31] TAYLOR K M,MORGAN H E,JOHNSON A,et al.
Cancer Res,2022,82(Suppl. 4):PD8-2-PD8-02. Structure-function analysis of LIV-1,the breast cancer-
[20] MODI S N,JACOT W,YAMASHITA T,et al. Trastu‐ associated protein that belongs to a new subfamily of zinc
zumab deruxtecan in previously treated HER-2-low ad‐ transporters[J]. Biochem J,2003,375(Pt 1):51-59.
vanced breast cancer[J]. N Engl J Med,2022,387(1): [32] SUSSMAN D,SMITH L M,ANDERSON M E,et al.
9-20. SGN-LIV1A:a novel antibody-drug conjugate targeting
[21] SHVARTSUR A,BONAVIDA B. TROP2 and its overex‐ LIV-1 for the treatment of metastatic breast cancer[J]. Mol
pression in cancers:regulation and clinical/therapeutic im‐ Cancer Ther,2014,13(12):2991-3000.
· 128 · China Pharmacy 2026 Vol. 37 No. 1 中国药房 2026年第37卷第1期

