Page 23 - 《中国药房》2025年15期

基于循证方法学和德尔菲法构建地佐辛注射液的药物利用评价

标准
Δ

＊
郭媛媛 ，王 超，秦寅鹏，张 弋，卜一珊（天津市第一中心医院药学部，天津 300192）
#
中图分类号 R95 文献标志码 A 文章编号 1001-0408（2025）15-1841-05
DOI 10.6039/j.issn.1001-0408.2025.15.04

摘 要 目的 构建地佐辛注射液的药物利用评价标准，为医疗机构合理用药提供参考。方法 以循证方法学为基础，查阅相关指
南/专家共识、系统评价/Meta分析，筛选证据后，初步建立地佐辛注射液的评价标准框架。采用德尔菲法，选择28位来自天津、北
京、山东等8个省份的二级及以上级别医疗机构的临床医师和临床药师，进行2轮问卷调查，根据专家积极系数、权威系数及协调
程度等确定最终指标。结果 2轮问卷有效回收率分别为100%和92.86%；2轮专家权威系数分别为0.82、0.81，专家协调程度分别
为0.29、0.31（P＜0.001）。最终形成包含用药指征、用药过程和用药结果三大维度，涵盖11个一级指标（如适应证、用法用量等）和
33个二级指标（如分娩镇痛、中大手术后重度疼痛镇痛应与其他镇痛药联合应用等）的地佐辛注射液药物利用评价标准体系，各
指标的重要性评分均值为4.08～5.00分，总体评分均值为4.61分，变异系数为0～0.19。结论 基于循证方法学和德尔菲法建立的
地佐辛注射液药物利用评价标准具有较好的权威性和科学性，为后续临床用药合理性评价提供了参考依据。
关键词 地佐辛注射液；药物利用；评价标准；循证方法学；德尔菲法

Construction of drug utilization evaluation criteria for Dezocine injection based on evidence-based
methodology and Delphi method
GUO Yuanyuan，WANG Chao，QIN Yinpeng，ZHANG Yi，BU Yishan（Dept. of Pharmacy， Tianjin First Central
Hospital， Tianjin 300192， China）

ABSTRACT OBJECTIVE To construct the drug utilization evaluation criteria for Dezocine injection， so as to provide reference

for the rational drug use in medical institutions. METHODS On the basis of evidence methodology， relevant guidelines/expert
consensus， systematic reviews/meta-analysis were consulted； the evaluation criteria framework for Dezocine injection was
established after screening evidence. Delphi method was employed， whereby 28 clinicians and clinical pharmacists from secondary
and above-level medical institutions across eight provinces， including Tianjin， Beijing and Shandong， were selected to participate
in two rounds of questionnaire surveys. The final indicators were determined based on the experts’ enthusiasm coefficient， authority
coefficient， and degree of coordination. RESULTS The effective recovery rate of questionnaire was 100% in the first round and
92.86% in the second round； expert authority coefficient was 0.82 in the first round and 0.81 in the second round； the coordination
degree of experts in the first round was 0.29， and in the second round was 0.31 （P＜0.001）. Drug utilization evaluation standard
system for Dezocine injection was formed finally， including three dimensions of medication indications， medication process and
medication results， with a total of 11 first-level indicators （such as indications， usage and dosage） and 33 second-level indicators
（such as labor analgesia and the management of severe pain following major or moderate surgeries combined with other analgesic
drugs）. The average importance scores for each indicator ranged from 4.08 to 5.00 points， with an overall average score of 4.61
points and coefficient of variation ranging from 0 to 0.19. CONCLUSIONS The drug utilization evaluation criteria for Dezocine
injection established based on evidence-based methodology and Delphi method is authoritative and scientific， which provides a
reference for subsequent evaluation of the rationality of clinical medication.
KEYWORDS Dezocine injection； drug utilization； evaluation criteria； evidence-based methodology； Delphi method

Δ 基金项目 白求恩公益基金会天津药学中青年科研项目（No.
TJYX2023-11） 地佐辛注射液作为新型的阿片受体激动-拮抗剂，
＊第一作者 副主任药师，硕士。研究方向：临床药学。E-mail： [1]
被广泛应用于中小手术术后镇痛及多模式联合镇痛 。
yyguoxj@163.com
近年来，其国内市场用量持续攀升，已占据了我国镇痛
# 通信作者 主任药师，硕士。研究方向：临床药学。E-mail：
[2]
buyishan@sina.com 药市场的巨大份额 。然而，随着地佐辛的广泛使用，其

中国药房 2025年第36卷第15期 China Pharmacy 2025 Vol. 36 No. 15 · 1841 ·