Page 125 - 《中国药房》2025年5期
P. 125
制剂手段以提高四君子汤有效成分的溶解度、稳定性, tion of the chemical constituents of Sijunzi decoction by
还可设计合理的临床试验,开展四君子汤的高质量临床 UHPLC coupled with Fourier transform ion cyclotron
研究,为四君子汤治疗胃癌提供更加完善的科学依据。 resonance mass spectrometry[J]. J Chromatogr B Analyt
参考文献 Technol Biomed Life Sci,2018,1086:11-22.
[ 9 ] 陈小霞,陈国忠,谢彩杏,等. 基于网络药理学和分子对
[ 1 ] 陈鹰娜,方芷若,谢志豪. 中药抗肿瘤有效成分及其作用
接分析古方四君子汤辅助治疗胃癌的作用机制[J]. 西部
机制[J]. 中药材,2023,46(9):2370-2376.
CHEN Y N,FANG Z R,XIE Z H. Effective anti-tumor 中医药,2024,37(4):72-76.
components of traditional Chinese medicine and their CHEN X X,CHEN G Z,XIE C X,et al. Analysis of the
mechanism of action[J]. J Chin Med Mater,2023,46(9): mechanism of ancient formula Sijunzi decoction in the ad‐
2370-2376. juvant treatment of gastric cancer based on network phar‐
[ 2 ] 成新平,姚继彬,安方玉,等. 扶正祛邪解毒类中药复方 macology and molecular docking[J]. West J Tradit Chin
Med,2024,37(4):72-76.
联合新辅助化疗在局部进展期胃癌中调控肿瘤免疫微
环 境 的 机 制 研 究 进 展 [J]. 中 国 药 事 ,2023,37(6): [10] 李燕,陈蓉,郭启靖,等 . 藏红花活性成分槲皮素通过
696-704. Bcl-2/Bax/Caspase-3 信号通路抑制胃癌进展[J]. 中国老
CHENG X P,YAO J B,AN F Y,et al. Research progress 年学杂志,2024,44(21):5286-5290.
on the mechanism of regulating tumor immune microenvi‐ LI Y,CHEN R,GUO Q J,et al. Quercetin,an active com‐
ronment in locally advanced gastric cancer by Fuzheng ponent of saffron,inhibits the progression of gastric can‐
quxie jiedu Chinese herbal compound combined with neo‐ cer through Bcl-2/Bax/Caspase-3 signaling pathway[J].
adjuvant chemotherapy[J]. Chin Pharm Aff,2023,37(6): Chin J Gerontol,2024,44(21):5286-5290.
696-704. [11] 于珊,郑熙. 四君子汤对胃癌MGC803细胞NFAT5及凋
[ 3 ] 梁华,张君成,李奇玮,等. 四君子汤及其加味方防治肿 亡因子表达的影响[J]. 中国中医药现代远程教育,2021,
瘤的机制研究进展[J]. 中医药学报,2022,50(1)86-90. 19(11):165-168.
LIANG H,ZHANG J C,LI Q W,et al. Research progress YU S,ZHENG X. Effect of Sijunzi decoction on expres‐
on mechanism of Sijunzi decoction and its modified for‐ sion of apoptosis molecules and NFAT5 of gastric cancer
mula in prevention and treatment of tumor[J]. Acta Chin cell MGC803[J]. Chin Med Mod Distance Educ China,
Med Pharmacol,2022,50(1):86-90. 2021,19(11):165-168.
[ 4 ] ZHOU G L,WANG C Z,MOHAMMADI S,et al. Phar‐ [12] 朱超,刘瑞,郭晨旭,等. 四君子汤及其拆方对胃癌SGC-
macological effects of ginseng:multiple cons tituents and 7901侧群细胞增殖、侵袭能力的影响[J]. 中国临床药理
multiple actions on humans[J]. Am J Chin Med,2023,51 学与治疗学,2015,20(11):1201-1207.
(5):1085-1104. ZHU C,LIU R,GUO C X,et al. Effects of Sijunzi decoc‐
[ 5 ] 张靓,唐芳婷,王红,等. 基于数据挖掘及网络药理学技 tion and its demolition party on the proliferation and inva‐
术探讨白术-党参治疗胃癌的作用机制[J]. 中医临床研 siveness of the side population of gastric cancer cell line
究,2023,15(30):16-24. SGC-7901[J]. Chin J Clin Pharmacol Ther,2015,20(11):
ZHANG L,TANG F T,WANG H,et al. The action 1201-1207.
mechanism of Baizhu-dangshen in the treatment of gastric [13] 聂闪闪,李洵,赵玉航,等. 加味四君子汤含药血清对胃
cancer based on data mining and network pharmacology 癌细胞 SGC-7901 凋亡相关因子表达的影响[J]. 中国实
[J]. Clin J Chin Med,2023,15(30):16-24. 验方剂学杂志,2019,25(9):25-30.
[ 6 ] 叶青,刘东升,王兰霞,等. 茯苓化学成分、药理作用及质 NIE S S,LI X,ZHAO Y H,et al. Effect of modified
量控制研究进展[J]. 中医药信息,2023,40(2): 75-79. Sijunzi decoction drug serum on expression of apoptosis-
YE Q,LIU D S,WANG L X,et al. Research progress on related molecules of gastric cancer cell SGC-7901[J].
chemical constituents,pharmacological effects and quality Chin J Exp Tradit Med Formulae,2019,25(9):25-30.
control of Poria cocos[J]. Inf Tradit Chin Med,2023,40 [14] DING P P,GUO Y T,WANG C H,et al. A network phar‐
(2):75-79. macology approach for uncovering the antitumor effects
[ 7 ] 韩维维,钟晴,张蓉,等. 甘草有效成分及其作用机制研 and potential mechanisms of the Sijunzi decoction for the
究进展[J]. 生命的化学,2023,43(12):1956-1962. treatment of gastric cancer[J]. Evid Based Complement
HAN W W,ZHONG Q,ZHANG R,et al. Research pro- Alternat Med,2022,2022:9364313.
gress of active constituents and their mechanism of action [15] 王逸美,李昌平. HP、中成药、Wnt/β-catenin信号通路与
in Glycyrrhiza uralensis Fisch[J]. Chem Life,2023,43 胃癌关系研究进展[J]. 现代临床医学,2023,49(4):
(12):1956-1962. 303-306.
[ 8 ] GUAN Z B,WANG M,CAI Y,et al. Rapid characteriza‐ WANG Y M,LI C P. Research progress on the relation‐
中国药房 2025年第36卷第5期 China Pharmacy 2025 Vol. 36 No. 5 · 627 ·