Page 101 - 《中国药房》2024年19期

绝经激素治疗中断的原因调查及影响因素分析
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周 婷 ，彭雪瑶，詹 侠，鲍红荣（杭州市临安区第一人民医院药剂科，杭州 311300）
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中图分类号 R977.1+2；R969.3 文献标志码 A 文章编号 1001-0408（2024）19-2411-05
DOI 10.6039/j.issn.1001-0408.2024.19.15

摘 要 目的 调查更年期综合征患者中断绝经激素治疗的原因，并分析可能导致治疗中断的影响因素。方法 回顾性选择2022
年3月－2023年11月在我院更年期医药联合门诊就诊并建立更年期保健手册的患者，通过手册登记的病史资料和门诊病历系统
收集其病例资料。电话随访已接受绝经激素治疗的患者，了解其是否在用药并统计治疗中断的原因。采用单因素分析和多因素
Logistic回归分析评价更年期综合征患者中断绝经激素治疗的影响因素。结果 纳入183例使用绝经激素治疗的患者，根据其是
否中断治疗分为中断组（78例）和继续治疗组（105例）。电话随访结果显示，中断的原因主要有自觉无效（16.67%）、担心用药风险
（15.38%）、存在慎用情况（12.82%）及发生不良反应（10.26%）。单因素分析结果显示，两组患者的职业、有无并发症、用药方案和
骨质、血黏度是否正常比较，差异均有统计学意义（P＜0.05）。多因素Logistic回归分析结果显示，无并发症、骨质减少及疏松、事
业单位工作及退休、使用连续序贯用药方案使患者倾向选择继续进行绝经激素治疗（P＜0.05）。结论 绝经激素治疗中断率较高，
自觉无效、担心用药风险、存在慎用情况和发生不良反应对患者影响较大。存在并发症会导致患者中断绝经激素治疗，而骨质减
少及疏松、事业单位工作及退休、使用连续序贯用药方案的患者则更倾向于选择继续进行绝经激素治疗。
关键词 更年期综合征；绝经激素治疗；治疗中断；影响因素

Investigation of the causes and analysis of influencing factors about interruption of menopausal hormone
therapy
ZHOU Ting，PENG Xueyao，ZHAN Xia，BAO Hongrong（Dept. of Pharmacy， Lin’an District First People’s
Hospital of Hangzhou， Hangzhou 311300， China）

ABSTRACT OBJECTIVE To investigate the reasons for interrupting menopausal hormone therapy in patients with menopausal
syndrome and analyze the influencing factors that may lead to treatment interruption. METHODS The patients who visited our
menopause medicine clinic from March 2022 to November 2023 and established a menopausal health manual were collected
retrospectively. The case data were collected through the medical history registered in the manual and the outpatient medical record
system. Telephone follow-up was conducted among the patients who had received menopausal hormone therapy to know about
whether they were taking medication and to record the reasons for treatment interruption. Univariate analysis and multivariate
Logistic regression analysis were adopted to investigate the influencing factors of discontinuing menopausal hormone therapy in
patients with menopausal syndrome. RESULTS A total of 183 patients receiving menopause hormone therapy were enrolled. They
were divided into interruption group （78 cases） and continuation group （105 cases） according to whether the treatment was
interrupted. The results of telephone follow-up showed that the reasons in turn for interruption were perceiving ineffectiveness
（16.67%）， concerning about medication risk（15.38%）， the existence of caution case（12.82%） and adverse reactions（10.26%）. The
results of univariate analysis showed that there were statistically significant differences in occupation， complications， medication
regimen， bone condition and blood viscosity between the two groups （P＜0.05）. Multivariate Logistic regression analysis showed
that the absence of complications， osteopenia and osteoporosis， working in public institution and retirement， and the continuous
sequential medication regimen favored continuation of menopausal hormone therapy （P＜0.05）. CONCLUSIONS The interruption
rate of menopausal hormone therapy is relatively high， and patients are greatly affected by perceiving ineffectiveness and
concerning about medication risks， the existence of caution case， and adverse reactions. Complications can cause patients to
interrupt treatment， while factors such as osteopenia and osteoporosis， working in public institutions and retirement， and continuous
sequential medication regimens make patients more inclined to choose to continue menopausal hormone therapy.
KEYWORDS menopausal syndrome； menopausal hormone therapy； interruption of treatment； influencing factors

更年期综合征是由女性绝经前后激素水平波动或
Δ 基金项目 杭州市临安区农业与社会发展科研引导项目（No.临 减少所致的一系列躯体及精神心理异常症状，具体可表
科字〔2023〕6号） 现为月经紊乱、潮热出汗、失眠、情绪波动大等近期症状
＊第一作者 主管药师，硕士。研究方向：妇产科临床药学。
[1]
和反复阴道感染、骨质疏松等远期症状 。40～60 岁女
E-mail：253012551@qq.com
性更年期综合征的患病率为 73.8%，其中围绝经期女性
# 通信作者 主 任 药 师 。 研 究 方 向 ：医 院 药 学 。 E-mail：
792271985@qq.com 患病率高达 81.7%；然而在有症状的女性中，仅 25.97%

中国药房 2024年第35卷第19期 China Pharmacy 2024 Vol. 35 No. 19 · 2411 ·