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他药物联用产生协同抗肿瘤效果。随着研究的不断深                                  lease  for  multilevel  chemotherapy  amplification  in  drug-
          入,越来越多的光敏剂被用于构建纳米递送系统。这些                                 resistant  breast  cancer[J].  Pharmaceutics, 2022, 14
          纳米递送系统不仅可以递送光敏剂,还可以同时递送化                                (2):422.
          疗药物,使其具有光疗和化疗的双重作用,极大地提高                            [ 9 ]  ZHANG H,TANG W L,KHEIROLOMOOM A,et al. De‐
          了乳腺癌的治疗效果。相信在未来的研究中,具有多重                                 velopment  of  thermosensitive  resiquimod-loaded  lipo‐
                                                                   somes  for  enhanced  cancer  immunotherapy[J].  J  Control
          作用的多功能纳米递送系统将会成为抗肿瘤药物研发
                                                                   Release,2021,330:1080-1094.
          的新方向。
                                                              [10]  LI  R,LIN  Z,ZHANG  Q,et  al.  Injectable  and  in  situ-
          4 结语                                                     formable thiolated chitosan-coated liposomal hydrogels as
              乳腺癌的治疗除了上述用于药物治疗、基因治疗及                               curcumin  carriers  for  prevention  of  in  vivo  breast  cancer
          光疗的纳米递送系统外,还有其他治疗方法,如磁热治                                 recurrence[J]. ACS Appl Mater Interfaces,2020,12(15):
          疗、声动力疗法以及放疗等的纳米递送系统也有很多文                                 17936-17948.
          献报道。每种治疗方法各有优势,通过这些纳米系统的                            [11]  TANG  Z,LUO  C,JUN Y,et  al.  Nanovector  assembled
          递送,都能使各种治疗剂高效准确地蓄积于肿瘤部位,                                 from natural egg yolk lipids for tumor-targeted delivery of
          显著提高乳腺癌的治疗效果,同时降低毒副作用。目                                  therapeutics[J]. ACS Appl Mater Interfaces,2020,12(7):
          前,这些纳米递送系统的药理作用在细胞和动物水平得                                 7984-7994.
          到了证实,但是真正被应用到临床上的却很少。在未来                            [12]  LANDGRAF  M,LAHR  C  A,KAUR  I,et  al.  Targeted
                                                                   camptothecin  delivery  via  silicon  nanoparticles  reduces
          的研究中,应加快纳米递送系统在临床上的研究,以期
                                                                   breast  cancer  metastasis[J].  Biomaterials,2020,240:
          为乳腺癌的治疗提供新方法。
                                                                   119791.
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          · 126 ·    China Pharmacy  2023 Vol. 34  No. 1                               中国药房  2023年第34卷第1期
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