Page 50 - 《中国药房》2022年13期
P. 50

caspase-1/GSDMD 信号通路表达增强,养心定悸胶囊可                         induced diabetes rat model[J]. J Cell Mol Med,2016,20
        通过调控该信号通路抑制DCM模型金黄地鼠心肌细胞                                (4):623-631.
        焦亡,减轻 DCM 炎症损伤,从而保护心肌细胞。然而,                         [15]  THAKUR V,ALCOREZA N,DELGADO M,et al. Cardio-
        中医药作用具有多途径、多靶点的特点,养心定悸胶囊                                 protective effect of glycyrrhizin on myocardial remode-
                                                                 ling in diabetic rats [J]. Biomolecules,2021,11(4):569.
        作为一种中成药,含9味中药,有效成分复杂,未来将进
                                                            [16]  刘天碧,门鹏,翟所迪.恩格列净治疗 2 型糖尿病的有效
        一步研究其有效成分,并进行离体实验验证,为临床用
                                                                 性和安全性的循证评价[J].中国新药杂志,2019,28(7):
        药提供更多的实验依据。
                                                                 877-885.
        参考文献                                                [17]  ZINMAN B,WANNER C,LACHIN J M,et al. Empa-
        [ 1 ]  HAYAT S A,PATEL B,KHATTAR R S,et al. Diabetic     gliflozin,cardiovascular outcomes,and mortality in type 2
             cardiomyopathy:mechanisms,diagnosis and treatment[J].  diabetes[J]. N Engl J Med,2015,373(22):2117-2128.
             Clin Sci(Lond),2004,107(6):539-557.            [18]  尚鑫,任晓霞,陈栋,等.抵挡汤对糖尿病心肌病小鼠
        [ 2 ]  BÖNI-SCHNETZLER M,MEIER D T. Islet inflammation   NLRP3 炎症小体的作用及机制[J].中国实验方剂学杂
             in type 2 diabetes[J]. Semin Immunopathol,2019,41(4):  志,2021,27(9):19-25.
             501-513.                                       [19]  沈莺. ADM2、RAAS系统功能变化对糖尿病患者心肌病
        [ 3 ]  ZENG C,WANG R Q,TAN H M. Role of pyroptosis in    病情发生发展的影响 [J].中国实验诊断学,2020,24
             cardiovascular diseases and its therapeutic implications[J].  (10):1639-1641.
             Int J Biol Sci,2019,15(7):1345-1357.           [20]  ZHU H F,WANG Y,LIU Z Q,et al. Antidiabetic and anti-
        [ 4 ]  LI L,LUO W,QIAN Y Y,et al. Luteolin protects against  oxidant effects of catalpol extracted from rehmannia gluti-
             diabetic cardiomyopathy by inhibiting NF-κB-mediated in-  nosa(Di Huang)on rat diabetes induced by streptozotocin
             flammation and activating the Nrf2-mediated antioxidant  and high-fat,high-sugar feed[J]. Chin Med,2016,11:25.
             responses[J]. Phytomedicine,2019,59:152774.    [21]  LI Y,HOU J G,LIU Z,et al. Alleviative effects of 20
        [ 5 ]  LUO B B,LI B,WANG W K,et al. NLRP3 gene silencing  (R)-Rg3 on HFD/STZ-induced diabetic nephropathy via
             ameliorates diabetic cardiomyopathy in a type 2 diabetes  MAPK/NF-κB signaling pathways in C57BL/6 mice[J]. J
             rat model[J]. PLoS One,2014,9(8):e104771.           Ethnopharmacol,2021,267:113500.
        [ 6 ]  刘娜,刘东升,韩海莉.养心定悸胶囊治疗缓慢性心律失                    [22]  FRATI G,SCHIRONE L,CHIMENTI I,et al. An over-
             常有效性及安全性的临床观察[J].中西医结合心脑血管                          view of the inflammatory signalling mechanisms in the
             病杂志,2019,17(24):4026-4029.                          myocardium underlying the development of diabetic car-
        [ 7 ]  郭子静,刘刚,马可心,等.养心定悸胶囊对异丙肾上腺素                        diomyopathy[J]. Cardiovasc Res,2017,113(4):378-388.
             诱导 SD 大鼠缺血性心律失常的拮抗作用及机制[J].中                   [23]  梁文杰,毕建成,许庆友.NLRP3炎症小体在慢性肾脏病
             华中医药学刊,2022,40(1):97-102,268.                       的表达及中药的干预机制[J].中药药理与临床,2016,32
        [ 8 ]  贾敏,王静,张冀东,等.养心定悸胶囊调控 NOS 途径改                     (3):208-211.
             善心肌缺血再灌注损伤及其引起的心律失常[J].中国医                     [24]  LIU Z W,ZHAO N,ZHU H L,et al. Circulating interleu-
             院药学杂志,2019,39(14):1444-1449.                        kin-1β promotes endoplasmic reticulum stress-induced
        [ 9 ]  高秀莹,周迎生. 2 型糖尿病鼠类模型的研究进展[J].中                     myocytes apoptosis in diabetic cardiomyopathy via inter-
             国实验动物学报,2014,22(4):71-76.                           leukin-1 receptor-associated kinase-2[J]. Cardiovasc Dia-
        [10]  刘文旗,戴红艳,邢明青,等.糖尿病心肌病动物模型的建                         betol,2015,14:125.
             立[J].中国组织工程究,2015,19(27):4265-4270.            [25]  SHEN N N,LI X G,ZHOU T,et al. Shensong Yangxin
        [11]  LI C G,ZHANG J,XUE M,et al. SGLT2 inhibition with  Capsule prevents diabetic myocardial fibrosis by inhibi-
             empagliflozin attenuates myocardial oxidative stress and  ting TGF-β1/Smad signaling[J]. J Ethnopharmacol,2014,
             fibrosis in diabetic mice heart[J]. Cardiovasc Diabetol,  157:161-170.
             2019,18(1):15.                                 [26]  XU D,ZHANG X Z,CHEN X,et al. Inhibition of miR223
        [12]  黄芷棋,宁一博,贺润铖,等. NLRP3炎性小体与糖尿病心                      attenuates the NLRP3 inflammasome activation,fibrosis,and
             肌病的发生发展[J].中国药理学通报,2021,37(4):463-467.              apoptosis in diabetic cardiomyopathy[J]. Life Sci,2020,
        [13]  QIN L H,WANG J P,ZHAO R R,et al. Ginsenoside-Rb1   256:117980.
             improved diabetic cardiomyopathy through regulating cal-  [27]  CAO R P,FANG D,WANG J H,et al. ALDH2 overex-
             cium signaling by alleviating protein O-GlcNAcylation[J].  pression alleviates high glucose-induced cardiotoxicity by
             J Agric Food Chem,2019,67(51):14074-14085.          inhibiting NLRP3 inflammasome activation[J]. J Diabetes
        [14]  YU H T,ZHEN J,YANG Y,et al. Ginsenoside Rg1 ame-   Res,2019,2019:4857921.
             liorates diabetic cardiomyopathy by inhibiting endoplasmic   (收稿日期:2021-12-22  修回日期:2022-04-30)
             Reticulum stress-induced apoptosis in a streptozotocin-                             (编辑:舒安琴)


        ·1580 ·  China Pharmacy 2022 Vol. 33 No. 13                                 中国药房    2022年第33卷第13期
   45   46   47   48   49   50   51   52   53   54   55