Page 92 - 《中国药房》2021年第1期

·药物与临床·

哌拉西林及其复方制剂致过敏性休克的病例报道及文献分析 Δ

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黄雅群 1，2＊ ，文睿婷 ，于芝颖 ，张春燕 ，任晓蕾 ，封宇飞（1.北京大学人民医院药剂科，北京 100044；2.北京大
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学医学部药学院药事管理与临床药学系，北京 100191）
中图分类号 R978.1 1；R969.3 文献标志码 A 文章编号 1001-0408（2021）01-0082-06
+
DOI 10.6039/j.issn.1001-0408.2021.01.15
摘 要 目的：探讨哌拉西林及其复方制剂致过敏性休克的临床特点，为该严重不良反应的防治提供参考。方法：分析北京大学
人民医院（以下简称“我院”）1例哌拉西林舒巴坦致过敏性休克病例，同时在Medline、中国知网、万方数据库、维普网中，检索建库
起至2020年7月报道的哌拉西林单药及其复方制剂致过敏性休克不良反应的相关文献，对纳入患者的性别与年龄分布、既往过敏
史、原发疾病及治疗情况、皮试情况、哌拉西林及其复方制剂给药方式及剂量、过敏性休克发生时间及主要表现、治疗措施及转归
情况进行分析，并提出防治建议。结果：我院1例患者为肝部分切除术后转入重症监护病房，使用哌拉西林舒巴坦预防术后感染
致患者发生过敏性休克。检索数据库共获得哌拉西林单药及其复方制剂致过敏性休克的相关文献28篇（涉及患者28例）。在所
有的29例患者中，男性12例、女性17例，年龄以50～59岁居多（6例，20.69％）；3例患者有过敏史（食物、乳胶手套等），患者原发疾
病多为感染性疾病或围术期使用该药；22例患者（75.86％）在用药前进行了皮试且结果均为阴性。27例通过静脉途径给药的患者
的可能致敏药物包括哌拉西林、哌拉西林舒巴坦、哌拉西林他唑巴坦，给药剂量根据原发疾病及严重程度有所差异，其中14例患
者（55.56％）在给药0～5 min内出现休克症状；主要表现为系统性过敏反应症状，主要累及循环系统。除2例死亡外，其余患者经
治疗后症状均缓解。结论：过敏史及皮试结果对哌拉西林及其复方制剂所致过敏性休克的预示作用有限；在使用该类药物期间需
密切监测患者生命体征变化，做好过敏性休克抢救准备，及时采取应对措施。
关键词 哌拉西林；舒巴坦；他唑巴坦；过敏性休克；不良反应

Piperacillin and Its Compound Preparation-induced Anaphylactic Shock：A Case Report and Literature
Analysis
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HUANG Yaqun ，WEN Ruiting ，YU Zhiying ，ZHANG Chunyan ，REN Xiaolei ，FENG Yufei（1. Dept. of
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Pharmacy， Peking University People’s Hospital， Beijing 100044， China； 2. Dept. of Pharmaceutical
Administration and Clinical Pharmacy，School of Pharmaceutical Sciences，Peking University Health Science
Center，Beijing 100191，China）
ABSTRACT OBJECTIVE：To investigate the clinical characteristics of anaphylactic shock induced by piperacillin and its
compound preparation，and to provide reference for prevention and treatment of the severe ADR. METHODS：A case of
anaphylactic shock induced by piperacillin and sulbactam were analyzed in our hospital，meanwhile ADR literatures about
piperacillin alone and its compound preparation-induced anaphylactic shock were collected from Medline，CNKI，Wanfang database
and VIP during the inception to Jul. 2020. Gender and age of patients，allergic history，primary disease and treatment，skin test，
administration route and dosage of piperacillin and its compound preparation，occurrence time and main manifestations of
anaphylactic shock，treatment measure and prognosis were analyzed，then prevention and treatment suggestions were put forward.
RESULTS：The patient in this case was transferred to the ICU after partial hepatectomy. The use of piperacillin and sulbactam to
prevent postoperative infection caused anaphylactic shock. A total of 28 literatures about anaphylactic shock induced by piperacillin
and its compound preparations were collected from the database（involving 28 patients）. Among totally 29 patients，there were 12
male and 17 female；the majority of patients were 50-59 years old（6 cases，20.69％）. Three patients had allergic history（food，
latex gloves，etc.），and most of the primary diseases were infectious diseases or the drug used in perioperative period. Skin tests
were carried out in 22 patients（75.86％）before medication and the results were negative. The possible allergenic drugs of 27 cases
which were administered by intravenous route included piperacillin，piperacillin sulbactam and piperacillin tazobactam. The dosage
was different according to the primary disease and severity. 14 patients（55.56％）developed anaphylactic shock within 5 minutes
after drug exposure. The main symptoms were systemic allergic reaction，mainly involving the circulatory system. Except for two
death cases，the other patients’symptoms were relieved after
Δ 基金项目：国家自然科学基金资助项目（No.81503050）
＊硕士研究生。研究方向：临床药学。电话：010-88325127。 treatment. CONCLUSIONS： Allergic history and skin test
E-mail：huangyaqun227@163.com results may have limitation in predicting anaphylactic shock
# 通信作者：副主任药师，硕士生导师，博士。研究方向：临床药 induced by piperacillin and its compound preparation. Close
学。电话：010-88325127。E-mail：tzwxm@bjmu.edu.cn monitoring needs to be taken in patients during these

·82 · China Pharmacy 2021 Vol. 32 No. 1 中国药房 2021年第32卷第1期