Page 42 - 202006
P. 42

能与激活 PPARγ途径有关。本研究首次阐明了桑叶总                              (22):5521-5523.
        黄酮用于治疗 GDM 的价值,为该症的防治提供了新思                          [13]  KHAMBULE L,GEORGE JA. The role of inflammation
        路。本课题组后续将在应用桑叶总黄酮的基础上联合                                  in the development o GDM and the use of markers of in-
        PPARγ抑制剂,以进一步验证桑叶总黄酮通过激活                                 flammation in GDM screening[J]. Adv Exp Med Biol,
        PPARγ途径来改善GDM的作用机制。                                      2019. DOI:10.1007/978-3-030-12668-1-12.
                                                            [14]  JONES ML,BUHIMSCHI IA,ZHAO G,et al. Acute glu-
        参考文献
                                                                 cose load,inflammation,oxidative stress,nonenzymatic
        [ 1 ]  LAW KP,ZHANG H. The pathogenesis and pathophysiol-  glycation,and screening for gestational diabetes[J]. Re-
             ogy of gestational diabetes mellitus:deductions from a
                                                                 prod Sci,2019. DOI:10.1177/1933719119831772.
             three-part longitudinal metabolomics study in China[J].
                                                            [15]  ZAMBON M,MANDÒ C,LISSONI A,et al. Inflammato-
             Clin Chim Acta,2017. DOI:10.1016/j.cca.2017.02.008.  ry and oxidative responses in pregnancies with obesity
        [ 2 ]  CHATUPHONPRASERT W,JARUKAMJORN K,ELLIN-
                                                                 and periodontal disease[J]. Reprod Sci,2018. DOI:
             GER I. Physiology and pathophysiology of steroid biosyn-
                                                                 10.1177/1933719117749758.
             thesis,transport and metabolism in the human placenta[J].
                                                            [16]  SIWETZ M,BLASCHITZ A,El-Heliebi A,et al. TNF-α
             Front Pharmacol,2018. DOI:10.3389/fphar.2018.01027.  alters the inflammatory secretion profile of human first tri-
        [ 3 ]  WHITE SL,PASUPATHY D,SATTAR N,et al. Metabol-
                                                                 mester placenta[J]. Lab Invest,2016,96(4):428-438.
             ic profiling of gestational diabetes in obese women during
                                                            [17]  KHOSROWBEYGI A,REZVANFAR MR,AHMAD-
             pregnancy[J]. Diabetologia,2017,60(10):1903-1912.
                                                                 VAND H. Tumor necrosis factor-α,adiponectin and their
        [ 4 ]  TASCHEREAU-CHARRON A,DA SILVA MS,BILODE-          ratio in gestational diabetes mellitus[J]. Caspian J Intern
             AU JF,et al. Alterations of fatty acid profiles in gestation-
                                                                 Med,2018,9(1):71-79.
             al diabetes and influence of the diet[J]. Maturitas,2017.
                                                            [18]  ZHANG C,YANG Y,CHEN R,et al. Aberrant expression
             DOI:10.1016/j.maturitas.2017.01.014.                of oxidative stress related proteins affects the pregnancy
        [ 5 ]  SKÓRZYŃSKA-DZIDUSZKO KE,KIMBER-TROJNAR
                                                                 outcome of gestational diabetes mellitus patients[J]. Am J
             Ż,PATRO-MAŁYSZA J,et al. An interplay between obe-
                                                                 Transl Res,2019,11(1):269-279.
             sity and inflammation in gestational diabetes mellitus[J].  [19]  MAGED AM,TORKY H,FOUAD MA,et al. Role of an-
             Curr Pharm Biotechnol,2016,17(7):603-613.           tioxidants in gestational diabetes mellitus and relation to
        [ 6 ]  孙鑫,马志,孟庆海,等.桑酮碱对 2 型糖尿病 db/db 小鼠
                                                                 fetal outcome:a randomized controlled trial[J]. J Matern
             血糖及肝脏胰岛素抵抗的影响[J].中成药,2017,39(5):                    Fetal Neonatal Med,2016,29(24):4049-4054.
             885-890.                                       [20]  CAI S,SUN W,FAN Y,et al. Effect of mulberry leaf(Fo-
        [ 7 ]  穆晓燕,李先佳.桑叶总黄酮对2型糖尿病大鼠胰岛B细                         lium Mori)on insulin resistance via IRS-1/PI3K/Glut-4
             胞的影响[J].中国实验方剂学杂志,2013,19(11):213-                  signalling pathway in type 2 diabetes mellitus rats[J].
             216.                                                Pharm Biol,2016,54(11):2685-2691.
        [ 8 ]  GAO Y,SHE R,SHA W. Gestational diabetes mellitus is  [21]  WEI J,LI X,GAO J. Insulin secretion and tolerance of
             associated with decreased adipose and placenta peroxi-  women with different gestational glucose regulation one
             someproliferator-activator receptor γ expression in a Chi-  year postpartum[J]. Int J Clin Exp Med,2015,8(4):
             nese population[J]. Oncotarget,2017,8(69):113928-   6384-6387.
             113937.                                        [22]  ZHANG Y,HUANG X,ZHOU J,et al. PPARγ provides
        [ 9 ]  KNABL J,HÜTTENBRENNER R,HUTTER S,et al. Per-      anti-inflammatory and protective effects in intrahepatic
             oxisome proliferator-activated receptor-gamma(PPARγ)  cholestasis of pregnancy through NF-κB pathway[J]. Bio-
             is down regulated in trophoblast cells of gestational diabe-  chem Biophys Res Commun,2018,504(4):834-842.
             tes mellitus(GDM)and in trophoblast tumour cells Be-  [23]  PHAM J,ARUL NAMBI RAJAN K,LI P,et al. The role
             Wo in vitro after stimulation with PPAR γ agonists[J]. J  of Sirtuin1-PPARγ axis in placental development and fun-
             Perinat Med,2014,42(2):179-187.                     ction[J]. J Mol Endocrinol,2018,60(4):R201-R212.
        [10]  汤梦雨,徐文婷,王彩红,等.高脂饲料联合链脲佐菌素诱                    [24]  KOHAN-GHADR HR,KILBURN BA,KADAM L,et al.
             导妊娠期糖尿病大鼠模型的优化方案[J].江苏大学学报                          Rosiglitazone augments antioxidant response in the hu-
             (医学版),2018,28(5):393-396.                           man trophoblast and prevents apoptosis[J]. Biol Reprod,
        [11]  中华医学会妇产科学分会产科学组,中华医学会围产医                           2019,100(2):479-494.
             学分会妊娠合并糖尿病协作组.妊娠合并糖尿病诊治指                       [25]  徐梦,马艳玲,赵奇红,等. PPARγ激动剂对妊娠期糖尿
             南:2014[J].中华妇产科杂志,2014,49(8):561-569.               病小鼠氧化应激和炎症水平的影响[J].中华疾病控制杂
        [12]  刘冬恋,凌保东,谭林,等.桑叶总黄酮对2型糖尿病大鼠                         志,2018,22(2):195-198.
             肝脏过氧化物酶体增殖物激活受体α和腺苷酸活化蛋白                                    (收稿日期:2019-06-21  修回日期:2020-01-06)
             激酶α2 蛋白表达的影响[J].中国老年学杂志,2017,37                                                     (编辑:张元媛)


        ·676  ·  China Pharmacy 2020 Vol. 31 No. 6                                   中国药房    2020年第31卷第6期
   37   38   39   40   41   42   43   44   45   46   47