Page 107 - 2019年8月第30卷第16期

·药物与临床·

《中医方剂大辞典》中含马钱子方剂的用药规律分析 Δ

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宋云燕 ，董 伟，梁新丽，欧丽泉，廖正根（江西中医药大学现代中药制剂教育部重点实验室，南昌 330004）
#
中图分类号 R286 文献标志码 A 文章编号 1001-0408（2019）16-2262-05
DOI 10.6039/j.issn.1001-0408.2019.16.20
摘 要 目的：为马钱子的临床合理使用及其药物剂型开发提供参考。方法：从《中医方剂大辞典》中收集整理含马钱子的方剂，
将方名、方源、治疗疾病名、组成、用法用量、用药途径等信息录入Access 2010软件并建立数据库，根据用法将这些方剂的用药途
径分为内服和外用，分别统计出内服/外用方剂所治疾病的频数；采用SPSS Modeler 18.0软件中的Apriori算法对含马钱子的复方
进行药物组方规律分析。结果：共纳入含马钱子方剂78首，其中42首为内服方剂，33首为外用方剂，3首为既可内服又可外用的
方剂。内服方剂主要用于治疗痿病、痹病、痔疮、肛瘘、筋骨疼痛等疾病；外用方剂主要用于治疗皮肤疾病、瘤、痞块等疾病；内服外
用皆可的方剂主要用于治疗疮疡病、跌打损伤和骨折。在内服方剂中，马钱子常配伍乳香、没药、血竭、穿山甲、自然铜、当归、麻
黄、草乌；在外用方剂中，马钱子常配伍赤芍、地黄、黄柏、黄连、黄芩、当归、白芷、全蝎。马钱子绝大多数经炮制后使用，且以麻油
作辅料炮制为主（占77.97％）。结论：含马钱子的方剂主要治疗疾病包括风湿痹痛、肢体瘫痪，跌打损伤、骨折以及痈疽肿毒、顽癣
三类。马钱子在外用方剂中多配伍清热燥湿、凉血活血、止痛药，在内服方剂中多配伍活血化瘀药。此外，用麻油炮制马钱子是保
证其安全性的重要措施。
关键词 马钱子；用药途径；主治疾病；组方规律；炮制；Apriori算法

Analysis of Medication Rules of the Prescription Containing Strychnos nuxvomica in the Dictionary of
Traditional Chinese Medicine Prescription
SONG Yunyan，DONG Wei，LIANG Xinli，OU Liquan，LIAO Zhenggen（Key Lab of Modern TCM Preparation，
Ministry of Education，Jiangxi University of TCM，Nanchang 330004，China）

ABSTRACT OBJECTIVE：To provide reference for the clinical use and dosage form development of Strychnos nuxvomica.
METHODS：The prescriptions containing S. nuxvomica were collected and sorted from the Dictionary of Traditional Chinese
Medicine Prescription，and then formula name，prescription source，name of treatment disease，composition，usage and dosage，
medication route were input into Access 2010 and database was established. According to the usage，these prescriptions were
divided into internal use and external use，and the frequencies of diseases treated by internal/external use prescriptions were counted
respectively. Apriori algorithm of SPSS Modeler 18.0 software was used to analyze the drug combination rule of compound
prescription containing S. nuxvomica. RESULTS：A total of 78 prescriptions were included，of which 42 were oral prescriptions，
33 were external prescriptions and 3 were both oral and external prescriptions. Internal prescriptions were used to treat diseases such
as atrophy-flaccidity disease，arthralgia，hemorrhoids，anal fistula，bones and muscles pain. The external prescriptions were mainly
used to treat skin diseases，tumors，lump. Internal and external prescriptions could treat sore，injuries and fractures. In internal

Association between PARP-1 V762A polymorphism and [18] ANIL S，GOPIKRISHNAN PB，BASHEER AB，et al. As-
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adducts，tobacco smoking，genetic susceptibility，and lung
Δ 基金项目：国家自然科学基金资助项目（No.81660757）；江西省
cancer risk[J]. Adv Clin Chem，2017. DOI：10.1016/bs.
主要学科学术和技术带头人资助项目（No.20162BCB22015）
acc.2017.01.006.
＊硕士研究生。研究方向：中药学。E-mail：yy201973@163.com
（收稿日期：2019-03-20 修回日期：2019-05-27）
# 通信作者：教授，博士生导师，博士。研究方向：中药制剂及新
（编辑：张元媛）
剂型。电话：0791-87118658。 E-mail：lyzlyg@163.com
·2262 · China Pharmacy 2019 Vol. 30 No. 16 中国药房 2019年第30卷第16期