Page 150 - 《中国药房》2026年8期
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tical%20development%20of%20medicines%20for%20pae‐   C K. Modern pediatric formulations of the soft candies in
               diatric,Categories%3A%20Quality%20%7C%20Pharma‐     the form of a jelly:determination of metoclopramide con‐
               ceutical%20development%20TGA%20annotations%3A%      tent and dissolution[J]. Pharm Dev Technol,2020,25(1):
               20Nil.                                              20-27.
          [10]  丛端端,孙艳喆,耿莹,等. 浅谈儿童用药的口感设计和                    [24]  LIU  F,RANMAL  S,BATCHELOR  H  K,et  al.  Patient-
               评价[J]. 中国医药工业杂志,2022,53(11):1659-1663.              centered  pharmaceutical  design  to  improve  acceptability
          [11]  苏昕玥,杨艳君,朱毛毛,等. 适用儿科制剂的辅料创新                         of medicines:similarities and differences in paediatric and
               研究技术体系、策略与发展趋势[J]. 中国中药杂志,                          geriatric populations[J]. Drugs,2014,74(16):1871-1889.
               2022,47(21):5700-5707.                         [25]  SAITO J,SHOJI K,MIYAIRI I,et al. Drug formulation
          [12]  SAITO J,AGRAWAL A,PATRAVALE V,et al. The cur‐      for pediatric oral antimicrobial agents in Japan:current sta‐
               rent states,challenges,ongoing efforts,and future perspec‐  tus,prospects,and  challenges[J].  Pediatr  Infect  Dis  J,
               tives of pharmaceutical excipients in pediatric patients in   2023,42(8):e298-e303.
               each country and region[J]. Children,2022,9(4):453.  [26]  SHAH H S,SYAMALA U,CHAUDHARI K,et al. Pro‐
          [13]  WIEDEY  R,KOKOTT  M,BREITKREUTZ  J.  Orodis‐       cess modelling,scale-up and characterization of aceta-
               persible  tablets  for  pediatric  drug  delivery:current  chal‐  minophen spray dried milk powder as novel pediatric
               lenges  and  recent  advances[J].  Expert  Opin  Drug  Deliv,  dosage form[J]. Pharm Res,2022,39(11):2885-2903.
               2021,18(12):1873-1890.                         [27]  KEAN  E  A,ADELEKE  O  A.  A  child-friendly  anti-
          [14]  THABET Y,WALSH J,BREITKREUTZ J. Flexible and       infective  gummy  formulation:  design,physicochemical,
               precise  dosing  of  enalapril  maleate  for  all  paediatric  age   micromechanical,and  taste  sensory  evaluation[J].  Drug
               groups utilizing orodispersible minitablets[J]. Int J Pharm,  Deliv Transl Res,2024,14(5):1319-1337.
               2018,541(1/2):136-142.                         [28]  MAWAZI S M,AL-MAHMOOD S M A,CHATTERJEE
          [15]  EDUARDO D T,ANA S E,JOSÉ B F. A micro-extrusion    B,et al. Carbamazepine gel formulation as a sustained re‐
               3D  printing  platform  for  fabrication  of  orodispersible   lease epilepsy medication for pediatric use[J]. Pharmaceu‐
               printlets  for  pediatric  use[J].  Int  J  Pharm,2021,605:  tics,2019,11(10):488.
               120854.                                        [29]  王洋洋,佟若菲,孙燕燕,等. 我国与欧盟儿童非处方药
          [16]  ÖZYıLMAZ E D,COMOGLU T. Development of pedia-     (化学药品单方制剂)适宜剂型与规格对比研究[J]. 药物
               tric  orally  disintegrating  mini-tablets  containing  atomo-  评价研究,2025,48(9):2401-2408.
               xetine  hydrochloride- β -cyclodextrin  inclusion  complex    [30]  STRICKLEY R G. Pediatric oral formulations:an updated
               using experimental design[J]. Drug Dev Ind Pharm,2022,  review  of  commercially  available  pediatric  oral  formula‐
               48(11):667-681.                                     tions since 2007[J]. J Pharm Sci,2019,108(4):1335-1365.
          [17]  ZUCCARI G,ALFEI S,MARIMPIETRI D,et al. Mini-  [31]  WALSH J,BICKMANN D,BREITKREUTZ J,et al. De‐
               tablets:a valid strategy to combine efficacy and safety in   livery devices for the administration of paediatric formula‐
               pediatrics[J]. Pharmaceuticals,2022,15(1):108.      tions: overview of current practice,challenges and recent
          [18]  KLINGMANN V. Acceptability  of  mini-tablets  in  young   developments[J]. Int J Pharm,2011,415(1/2):221-231.
               children:results from three prospective cross-over studies  [32]  YIN H S,PARKER R M,SANDERS L M,et al. Liquid
               [J]. AAPS PharmSciTech,2017,18(2):263-266.          medication  errors  and  dosing  tools:a  randomized  con‐
          [19]  KLINGMANN V,LINDERSKAMP H,MEISSNER T,et            trolled experiment[J]. Pediatrics,2016,138(4):e20160357.
               al.  Acceptability  of  multiple  uncoated  minitablets  in  in‐  [33]  RAWAT S S,RAI A,RATHI R,et al. Medicated straw:an
               fants and toddlers:a randomized controlled trial[J]. J Pe-  innovative drug delivery system for paediatrics[J]. Expert
               diatr,2018,201:202-207.                             Opin Drug Deliv,2023,20(3):313-314.
          [20]  GUPTA M S,KUMAR T P,GOWDA D V,et al. Orodis‐  [34]  HEJDUK  A,LULEK  J.  Dispensing  of  minitablets:  has
               persible  films:  conception  to  quality  by  design[J].  Adv   the  problem  been  resolved[J].  Int  J  Pharm,2022,619:
               Drug Deliv Rev,2021,178:113983.
                                                                   121666.
          [21]  KLINGMANN V,POHLY C E,MEISSNER T,et al. Ac‐   [35]  MALKAWI W A,ALRAFAYAH E,ALHAZABREH M,
               ceptability of an orodispersible film compared to syrup in
                                                                   et al. Formulation challenges and strategies to develop pe‐
               neonates and infants:a randomized controlled trial[J]. Eur   diatric dosage forms[J]. Children,2022,9(4):488.
               J Pharm Biopharm,2020,151:239-245.
                                                              [36]  MFOAFO K A,OMIDIAN M,BERTOL C D,et al. Neo‐
          [22]  CHACHLIOUTAKI K,TZIMTZIMIS E K,TZETZIS D,          natal and pediatric oral drug delivery: hopes and hurdles
               et al. Electrospun orodispersible films of isoniazid for pe‐
                                                                   [J]. Int J Pharm,2021,597:120296.
               diatric tuberculosis treatment[J]. Pharmaceutics,2020,12
                                                                            (收稿日期:2025-10-27  修回日期:2026-04-08)
              (5):470.
                                                                                                  (编辑:孙 冰)
          [23]  KARAISKOU S G,KOUSKOURA M G,MARKOPOULOU


          · 1104 ·    China Pharmacy  2026 Vol. 37  No. 8                              中国药房  2026年第37卷第8期
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