Page 150 - 《中国药房》2026年8期
P. 150
tical%20development%20of%20medicines%20for%20pae‐ C K. Modern pediatric formulations of the soft candies in
diatric,Categories%3A%20Quality%20%7C%20Pharma‐ the form of a jelly:determination of metoclopramide con‐
ceutical%20development%20TGA%20annotations%3A% tent and dissolution[J]. Pharm Dev Technol,2020,25(1):
20Nil. 20-27.
[10] 丛端端,孙艳喆,耿莹,等. 浅谈儿童用药的口感设计和 [24] LIU F,RANMAL S,BATCHELOR H K,et al. Patient-
评价[J]. 中国医药工业杂志,2022,53(11):1659-1663. centered pharmaceutical design to improve acceptability
[11] 苏昕玥,杨艳君,朱毛毛,等. 适用儿科制剂的辅料创新 of medicines:similarities and differences in paediatric and
研究技术体系、策略与发展趋势[J]. 中国中药杂志, geriatric populations[J]. Drugs,2014,74(16):1871-1889.
2022,47(21):5700-5707. [25] SAITO J,SHOJI K,MIYAIRI I,et al. Drug formulation
[12] SAITO J,AGRAWAL A,PATRAVALE V,et al. The cur‐ for pediatric oral antimicrobial agents in Japan:current sta‐
rent states,challenges,ongoing efforts,and future perspec‐ tus,prospects,and challenges[J]. Pediatr Infect Dis J,
tives of pharmaceutical excipients in pediatric patients in 2023,42(8):e298-e303.
each country and region[J]. Children,2022,9(4):453. [26] SHAH H S,SYAMALA U,CHAUDHARI K,et al. Pro‐
[13] WIEDEY R,KOKOTT M,BREITKREUTZ J. Orodis‐ cess modelling,scale-up and characterization of aceta-
persible tablets for pediatric drug delivery:current chal‐ minophen spray dried milk powder as novel pediatric
lenges and recent advances[J]. Expert Opin Drug Deliv, dosage form[J]. Pharm Res,2022,39(11):2885-2903.
2021,18(12):1873-1890. [27] KEAN E A,ADELEKE O A. A child-friendly anti-
[14] THABET Y,WALSH J,BREITKREUTZ J. Flexible and infective gummy formulation: design,physicochemical,
precise dosing of enalapril maleate for all paediatric age micromechanical,and taste sensory evaluation[J]. Drug
groups utilizing orodispersible minitablets[J]. Int J Pharm, Deliv Transl Res,2024,14(5):1319-1337.
2018,541(1/2):136-142. [28] MAWAZI S M,AL-MAHMOOD S M A,CHATTERJEE
[15] EDUARDO D T,ANA S E,JOSÉ B F. A micro-extrusion B,et al. Carbamazepine gel formulation as a sustained re‐
3D printing platform for fabrication of orodispersible lease epilepsy medication for pediatric use[J]. Pharmaceu‐
printlets for pediatric use[J]. Int J Pharm,2021,605: tics,2019,11(10):488.
120854. [29] 王洋洋,佟若菲,孙燕燕,等. 我国与欧盟儿童非处方药
[16] ÖZYıLMAZ E D,COMOGLU T. Development of pedia- (化学药品单方制剂)适宜剂型与规格对比研究[J]. 药物
tric orally disintegrating mini-tablets containing atomo- 评价研究,2025,48(9):2401-2408.
xetine hydrochloride- β -cyclodextrin inclusion complex [30] STRICKLEY R G. Pediatric oral formulations:an updated
using experimental design[J]. Drug Dev Ind Pharm,2022, review of commercially available pediatric oral formula‐
48(11):667-681. tions since 2007[J]. J Pharm Sci,2019,108(4):1335-1365.
[17] ZUCCARI G,ALFEI S,MARIMPIETRI D,et al. Mini- [31] WALSH J,BICKMANN D,BREITKREUTZ J,et al. De‐
tablets:a valid strategy to combine efficacy and safety in livery devices for the administration of paediatric formula‐
pediatrics[J]. Pharmaceuticals,2022,15(1):108. tions: overview of current practice,challenges and recent
[18] KLINGMANN V. Acceptability of mini-tablets in young developments[J]. Int J Pharm,2011,415(1/2):221-231.
children:results from three prospective cross-over studies [32] YIN H S,PARKER R M,SANDERS L M,et al. Liquid
[J]. AAPS PharmSciTech,2017,18(2):263-266. medication errors and dosing tools:a randomized con‐
[19] KLINGMANN V,LINDERSKAMP H,MEISSNER T,et trolled experiment[J]. Pediatrics,2016,138(4):e20160357.
al. Acceptability of multiple uncoated minitablets in in‐ [33] RAWAT S S,RAI A,RATHI R,et al. Medicated straw:an
fants and toddlers:a randomized controlled trial[J]. J Pe- innovative drug delivery system for paediatrics[J]. Expert
diatr,2018,201:202-207. Opin Drug Deliv,2023,20(3):313-314.
[20] GUPTA M S,KUMAR T P,GOWDA D V,et al. Orodis‐ [34] HEJDUK A,LULEK J. Dispensing of minitablets: has
persible films: conception to quality by design[J]. Adv the problem been resolved[J]. Int J Pharm,2022,619:
Drug Deliv Rev,2021,178:113983.
121666.
[21] KLINGMANN V,POHLY C E,MEISSNER T,et al. Ac‐ [35] MALKAWI W A,ALRAFAYAH E,ALHAZABREH M,
ceptability of an orodispersible film compared to syrup in
et al. Formulation challenges and strategies to develop pe‐
neonates and infants:a randomized controlled trial[J]. Eur diatric dosage forms[J]. Children,2022,9(4):488.
J Pharm Biopharm,2020,151:239-245.
[36] MFOAFO K A,OMIDIAN M,BERTOL C D,et al. Neo‐
[22] CHACHLIOUTAKI K,TZIMTZIMIS E K,TZETZIS D, natal and pediatric oral drug delivery: hopes and hurdles
et al. Electrospun orodispersible films of isoniazid for pe‐
[J]. Int J Pharm,2021,597:120296.
diatric tuberculosis treatment[J]. Pharmaceutics,2020,12
(收稿日期:2025-10-27 修回日期:2026-04-08)
(5):470.
(编辑:孙 冰)
[23] KARAISKOU S G,KOUSKOURA M G,MARKOPOULOU
· 1104 · China Pharmacy 2026 Vol. 37 No. 8 中国药房 2026年第37卷第8期

