Page 142 - 《中国药房》2025年20期
P. 142
plays a role in the beneficial effects of semaglutide(GLP- [28] BEIROA D,IMBERNON M,GALLEGO R,et al. GLP-1
1 receptor agonist)on the liver of obese mice[J]. Clin Res agonism stimulates brown adipose tissue thermogenesis
Hepatol Gastroenterol,2022,46(6):101922. and browning through hypothalamic AMPK[J]. Diabetes,
[18] PERFIELD J W,2nd,ORTINAU L C,PICKERING R T, 2014,63(10):3346-3358.
et al. Altered hepatic lipid metabolism contributes to non‐ [29] LOCKIE S H,HEPPNER K M,CHAUDHARY N,et al.
alcoholic fatty liver disease in leptin-deficient ob/ob mice Direct control of brown adipose tissue thermogenesis by
[J]. J Obes,2013,2013:296537. central nervous system glucagon-like peptide-1 receptor
[19] SOTO-CATALÁN M,OPAZO-RÍOS L,QUICENO H,et signaling[J]. Diabetes,2012,61(11):2753-2762.
al. Semaglutide improves liver steatosis and de novo lipo‐ [30] ZHAO L,CHEN Y,XIA F Z,et al. A glucagon-like pep‐
genesis markers in obese and type-2-diabetic mice with tide-1 receptor agonist lowers weight by modulating the
metabolic-dysfunction-associated steatotic liver disease structure of gut microbiota[J]. Front Endocrinol (Lausanne),
[J]. Int J Mol Sci,2024,25(5):2961. 2018,9:233.
[20] VENDRELL J,EL BEKAY R,PERAL B,et al. Study of [31] DENG X L,MA J,SONG M T,et al. Effects of products
the potential association of adipose tissue GLP-1 receptor designed to modulate the gut microbiota on hyperlipidae‐
with obesity and insulin resistance[J]. Endocrinology, mia[J]. Eur J Nutr,2019,58(7):2713-2729.
2011,152(11):4072-4079. [32] ZENG Y,WU Y F,ZHANG Q,et al. Crosstalk between
glucagon-like peptide 1 and gut microbiota in metabolic
[21] CHEN J C,ZHAO H C,MA X L,et al. GLP-1/GLP-1R
diseases[J]. mBio,2024,15(1):e0203223.
signaling in regulation of adipocyte differentiation and li‐
[33] ZHAO L,QIU Y,ZHANG P P,et al. Gut microbiota me‐
pogenesis[J]. Cell Physiol Biochem,2017,42(3):1165-
diates positive effects of liraglutide on dyslipidemia in
1176.
mice fed a high-fat diet[J]. Front Nutr,2022,9:1048693.
[22] LI Y M,DU J Y,ZHU E D,et al. Liraglutide suppresses
[34] MAO T H,ZHANG C X,YANG S,et al. Semaglutide al‐
proliferation and induces adipogenic differentiation of
ters gut microbiota and improves NAFLD in db/db mice
3T3-L1 cells via the Hippo-YAP signaling pathway[J].
[J]. Biochem Biophys Res Commun,2024,710:149882.
Mol Med Rep,2018,17(3):4499-4507.
[35] RODBARD H W,LINGVAY I,REED J,et al. Semaglu‐
[23] ZHANG J M,YANG G C,LIU J B,et al. Glucagon-like
tide added to basal insulin in type 2 diabetes(SUSTAIN
peptide-1 analog liraglutide reduces fat deposition in
5):a randomized,controlled trial[J]. J Clin Endocrinol
chicken adipocytes[J]. Poult Sci,2024,103(7):103766.
Metab,2018,103(6):2291-2301.
[24] ZHU R Y,CHEN S C. Proteomic analysis reveals sema-
[36] DAHL K,BROOKS A,ALMAZEDI F,et al. Oral sema-
glutide impacts lipogenic protein expression in epididymal
glutide improves postprandial glucose and lipid metabo‐
adipose tissue of obese mice[J]. Front Endocrinol
lism,and delays gastric emptying,in subjects with type 2
(Lausanne),2023,14:1095432.
diabetes[J]. Diabetes Obes Metab,2021,23(7):1594-
[25] LI H,LIU G,WAN X Q,et al. The zinc finger and BTB
1603.
domain containing protein ZBTB20 regulates plasma tri-
[37] LOOMBA R,ABDELMALEK M F,ARMSTRONG M J,
glyceride metabolism by repressing lipoprotein lipase
et al. Semaglutide 2.4 mg once weekly in patients with
gene transcription in hepatocytes[J]. Hepatology,2022,75
non-alcoholic steatohepatitis-related cirrhosis: a ran‐
(5):1169-1180. domised,placebo-controlled phase 2 trial[J]. Lancet Gas‐
[26] LI Y,GAO R,YANG Z Y,et al. Liraglutide modulates troenterol Hepatol,2023,8(6):511-522.
lipid metabolism via ZBTB20-LPL pathway[J]. Life Sci, [38] SVANE M S,JOHANNESEN H H,HANSEN A E,et al.
2025,360:123267. Four weeks treatment with the GLP-1 receptor analogue li‐
[27] NOGUEIRAS R,PÉREZ-TILVE D,VEYRAT-DUREBEX raglutide lowers liver fat and concomitantly circulating
C,et al. Direct control of peripheral lipid deposition by glucagon in individuals with overweight[J]. Int J Obes
CNS GLP-1 receptor signaling is mediated by the sympa‐ (Lond),2022,46(11):2058-2062.
thetic nervous system and blunted in diet-induced obesity (收稿日期:2025-05-08 修回日期:2025-09-22)
[J]. J Neurosci,2009,29(18):5916-5925. (编辑:邹丽娟)
· 2620 · China Pharmacy 2025 Vol. 36 No. 20 中国药房 2025年第36卷第20期

