Page 7 - 《中国药房》2025年4期

·指南与共识·

山东省围手术期非甾体抗炎药合理使用与临床综合评价专家共识 Δ

山东省药师协会临床药学专业委员会，山东省医学会临床个体化用药检测与指导分会，山东省药师协会药品临
床综合评价工作委员会，山东省医学会疼痛学分会，《山东省围手术期非甾体抗炎药合理使用与临床综合评价

专家共识》制定组

中图分类号 R969.3 文献标志码 A 文章编号 1001-0408（2025）04-0385-10
DOI 10.6039/j.issn.1001-0408.2025.04.01

摘 要 目的 为非甾体抗炎药（NSAIDs）在围手术期的合理使用提供依据，为医疗机构评价、遴选NSAIDs提供实践方法与技术
参考。方法 由青岛大学附属医院发起，山东省药师协会临床药学专业委员会、山东省医学会临床个体化用药检测与指导分会、山
东省药师协会药品临床综合评价工作委员会、山东省医学会疼痛学分会等联合山东省内多家医疗机构，组织来自山东省内17家
医院的22名药学和医学专家，基于循证医学证据，通过文献研究法、专家访谈法和问卷调查法，构建围手术期NSAIDs的合理用药
和临床综合评价专家共识，并对山东省内临床常用的包括塞来昔布、依托考昔、艾瑞昔布、布洛芬在内的9个品种共计13个品规
（含参比/原研及国家/山东省集中带量采购品种）药品进行临床综合评价。结果与结论 本研究对围手术期术前预防性使用和术后
使用NSAIDs以及使用禁忌、消化道风险、心血管系统风险、出血风险和肾损伤风险形成了共识意见，建立了包含安全性、有效性、
经济性、创新性、适宜性、可及性6个维度的围手术期NSAIDs使用评价与遴选标准。临床综合评价结果显示，得分排名前6（均超
过70分）的药品依次为塞来昔布胶囊（西乐葆）和塞来昔布胶囊（奈奇）、双氯芬酸钠缓释片、依托考昔片（安康信）和依托考昔片
（齐明舒）、注射用帕瑞昔布钠。随着临床研究的进展，本共识将会进一步更新和调整；医疗机构可结合实践情况，制定适合本医疗
机构的NSAIDs临床综合评价体系。
关键词 非甾体抗炎药；围手术期；合理用药；临床综合评价；专家共识

Expert consensus on perioperative rational use and comprehensive clinical evaluation of NSAIDs in
Shandong Province
Clinical Pharmacy Professional Committee of the Shandong Pharmacists Association， Clinical Individualised
Drug Testing and Guidance Branch of the Shandong Medical Association， Comprehensive Clinical Medication
Evaluation Working Committee of the Shandong Pharmacists Association， Pain Branch of the Shandong Medical
Association， Working Group of Expert Consensus on Perioperative Rational Use and Comprehensive Clinical
Evaluation of NSAIDs in Shandong Province

ABSTRACT OBJECTIVE To provide a basis for the rational use of nonsteroidal anti-inflammatory drugs （NSAIDs） in the
perioperative period， and provide practical methods and technical references for the evaluation and selection of NSAIDs in medical
institutions. METHODS Initiated by the Affiliated Hospital of Qingdao University， Clinical Pharmacy Professional Committee of
the Shandong Pharmacists Association， Clinical Individualised Drug Testing and Guidance Branch of the Shandong Medical
Association， Comprehensive Clinical Medication Evaluation Working Committee of the Shandong Pharmacists Association， Pain
Branch of the Shandong Medical Association in conjunction with several medical institutions in Shandong Province organized 22
pharmaceutical experts and medical experts from 17 hospitals in Shandong Province to form a consensus on the rational use and
comprehensive clinical evaluation of NSAIDs in the perioperative period through the literature research method， expert interview
method and questionnaire survey method based on evidence-based medicine. A comprehensive clinical evaluation was also
conducted on a total of 13 specifications of 9 commonly used clinical drug varieties in Shandong Province， including celecoxib，
etoricoxib， imrecoxib， ibuprofen （containing reference/original drugs and national/Shandong Province’s centralized volume-based
procurement varieties）. RESULTS & CONCLUSIONS A consensus opinion was formed on preoperative prophylactic use and
postoperative use of NSAIDs， as well as contraindications， digestive tract risk， cardiovascular system risk， bleeding risk and
kidney injury risk in the perioperative period. The evaluation and selection criteria of perioperative use of NSAIDs were established，
involving 6 dimensions of safety， efficacy， economy， innovation， appropriateness， and accessibility. The results of comprehensive
clinical evaluation showed that the top 6 drugs （scores over
Δ 基金项目 山东省自然科学基金面上项目（No.ZR2022MH069）
# 通信作者 荆凡波，主任药师，博士。研究方向：疼痛药物治疗。 70） were Celecoxib capsules （Celebrex） and Celecoxib
电话：0532-82913098。E-mail：jingbf178@sina.com capsules （Naiqi）， Diclofenac sodium sustained-release tablets，

中国药房 2025年第36卷第4期 China Pharmacy 2025 Vol. 36 No. 4 · 385 ·