Page 138 - 《中国药房》2024年23期

[24] LI J，LIU J，ENDERS J，et al. Discovery of a novel deami‐ dization LC-MS/MS methodology for quantification of
nated metabolite of a single-stranded oligonucleotide in siRNA in plasma，CSF and tissue samples[J]. Molecules，
vivo by mass spectrometry[J]. Bioanalysis，2019，11（21）： 2023，28（4）：1618.
1955-1965. [36] NGUYEN J M，GILAR M，KOSHEL B，et al. Assessing
[25] LIU A W，XIAO X，WANG J W，et al. Metabolite profi- the impact of nonspecific binding on oligonucleotide bio‐
ling of chemically modified oligonucleotides in rat liver analysis[J]. Bioanalysis，2021：13（16）：1233-1244.
homogenates using hydrophilic interaction liquid chroma- [37] ZHANG G D，LIN J，SRINIVASAN K，et al. Strategies
tography-high resolution mass spectrometry[J]. Micro‐ for bioanalysis of an oligonucleotide class macromolecule
chem J，2024，202：110797. from rat plasma using liquid chromatography-tandem mass
[26] SUN Y C，NITTA S I，SAITO K，et al. Development of a spectrometry[J]. Anal Chem，2007，79（9）：3416-3424.
bioanalytical method for an antisense therapeutic using [38] SUN Y C，NITTA S I，SAITO K，et al. Development and
high-resolution mass spectrometry[J]. Bioanalysis，2020， multicenter validation of an LC-MS-based bioanalytical
12（24）：1739-1756. method for antisense therapeutics[J]. Bioanalysis，2022，14
[27] LI X Q，ELEBRING M，DAHLÉN A，et al. In vivo me‐ （18）：1213-1227.
tabolite profiles of an N-acetylgalactosamine-conjugated [39] SIMEONE J，PATEL A V，DELANO M，et al. Optimizing
antisense oligonucleotide AZD8233 using liquid chroma‐ test approaches for the detection of exposed metal sur‐
tography high-resolution mass spectrometry：a cross- faces within a chromatographic flow path[J]. J Chro‐
species comparison in animals and humans[J]. Drug matogr A，2022，1666：462855.
Metab Dispos，2023，51（10）：1350-1361. [40] EWLES M，LEDVINA A R，POWERS B，et al. Observa‐
[28] KILANOWSKA A，NUCKOWSKI Ł，STUDZIŃSKA S. tions from a decade of oligonucleotide bioanalysis by LC-
Studying in vitro metabolism of the first and second ge- MS[J]. Bioanalysis，2024，16（12）：615-629.
neration of antisense oligonucleotides with the use of [41] LIU R，LUO Q，LIU Z Q，et al. Optimizing sample prepa‐
ultra-high-performance liquid chromatography coupled ration workflow for bioanalysis of oligonucleotides
with quadrupole time-of-flight mass spectrometry[J]. Anal through liquid chromatography tandem mass spectrometry
Bioanal Chem，2020，412（27）：7453-7467. [J]. J Chromatogr A，2020，1629：461473.
[29] NEEDHAM S R. Microspray and microflow liquid chro‐ [42] STUDZIŃSKA S，ŁOBODZIŃSKI F，BUSZEWSKI B.
matography：the way forward for LC-MS bioanalysis[J]. Application of hydrophilic interaction liquid chromatography
Bioanalysis，2017，9（24）：1935-1937. coupled with mass spectrometry in the analysis of phospho-
[30] JIANG D，YUAN L. Microflow LC-MS/MS to improve rothioate oligonucleotides in serum[J]. J Chromatogr B
sensitivity for antisense oligonucleotides bioanalysis：criti‐ Analyt Technol Biomed Life Sci，2017，1040：282-288.
cal role of sample cleanness[J]. Bioanalysis，2022，14 [43] KACZMARKIEWICZ A，NUCKOWSKI Ł，STUDZIŃSKA
（21）：1365-1376. S. Analysis of the first and second generation of antisense
[31] GUIMARAES G J，LEACH F E，BARTLETT M G. Mi‐ oligonucleotides in serum samples with the use of ultra
croflow liquid chromatography-multi-emitter nanoelectro‐ high performance liquid chromatography coupled with
spray mass spectrometry of oligonucleotides[J]. J Chro‐ tandem mass spectrometry[J]. Talanta，2019，196：54-63.
matogr A，2023，1696：463976. [44] ANAND P，KOLETO M，KANDULA D R，et al. Novel
[32] DILLEN L，SIPS L，GREWAY T，et al. Quantitative hydrophilic-phase extraction，HILIC and high-resolution
analysis of imetelstat in plasma with LC-MS/MS using MS quantification of an RNA oligonucleotide in plasma
solid-phase or hybridization extraction[J]. Bioanalysis， [J]. Bioanalysis，2022，14（1）：47-62.
2017，9（23）：1859-1872. [45] MACNEILL R，HUTCHINSON T，ACHARYA V，et al.
[33] LI P，GONG Y Q，KIM J，et al. Hybridization liquid An oligonucleotide bioanalytical LC-SRM methodology
chromatography-tandem mass spectrometry：an alternative entirely liberated from ion-pairing[J]. Bioanalysis，2019，
bioanalytical method for antisense oligonucleotide quanti‐ 11（12）：1157-1169.
tation in plasma and tissue samples[J]. Anal Chem，2020， [46] YUAN L，DUPUIS J F，VRIONIS V，et al. A validated
92（15）：10548-10559. capillary microsampling liquid chromatography-tandem
[34] LI P，DUPUIS J F，VRIONIS V，et al. Validation and mass spectrometry method for quantification of antisense
application of hybridization liquid chromatography-tandem oligonucleotides in mouse serum[J]. Bioanalysis，2023，15
mass spectrometry methods for quantitative bioanalysis of （12）：683-694.
antisense oligonucleotides[J]. Bioanalysis，2022，14（9）： （收稿日期：2024-04-17 修回日期：2024-11-19）
589-601. （编辑：胡晓霖）
[35] YUAN L，DUPUIS J F，MEKHSSIAN K. A novel hybri-

· 2964 · China Pharmacy 2024 Vol. 35 No. 23 中国药房 2024年第35卷第23期