Page 43 - 《中国药房》2020年23期

主客观组合赋权法结合质量常数法划分酒黄连饮片的等级 Δ

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王雪莲 ，穆成林 ，卢焘韬 ，唐丽婧 ，周 欣 ，康 希 ，杨荣平 （1.西南大学药学院，重庆 400715；2.成都中
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医药大学药学院，成都 611137）
中图分类号 R917 文献标志码 A 文章编号 1001-0408（2020）23-2853-05
DOI 10.6039/j.issn.1001-0408.2020.23.07
摘 要 目的：为酒黄连饮片的质量控制与评价提供参考。方法：以不同厂家的17批酒黄连饮片为考察样品，采用高效液相色谱
法测定其中表小檗碱、黄连碱、巴马汀、小檗碱等4种生物碱的含量；利用主客观组合赋权法（层次分析法结合变异系数法）计算表
小檗碱、黄连碱、巴马汀、小檗碱的复合权重，然后采用质量评价法结合饮片外观形态和4种生物碱含量对其进行质量评价，计算
百分质量常数并据此对酒黄连饮片进行等级划分。结果：根据4种生物碱含量测定结果，17批样品中共有13批样品符合2015年
版《中国药典》（四部）要求。合格的 13 批样品的质量常数为 10.03～26.96，百分质量常数为 37.20％～100％。若将百分质量常
数≥80％的样品列为一等品，百分质量常数为50％～＜80％的列为二等品，其余的列为三等品，则一等品的质量常数≥21.57，二
等品的质量常数为13.48～＜21.57，三等品的质量常数＜13.48。根据该分级标准，13批合格样品中共有3批被划分为一等品，6批
被划分为二等品，4批被划分为三等品。结论：本研究建立的主客观组合赋权法结合质量常数法可更科学、合理地对酒黄连饮片
进行等级划分。
关键词 酒黄连饮片；主客观赋权法；质量常数；百分质量常数；等级评价
Classification of Rice-wine Processed Coptidis Rhizoma Decoction Piece Based on Subjective and Objective
Combination Weighting Method and Quality Constant Method
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WANG Xuelian ，MU Chenglin ，LU Taotao ，TANG Lijing ，ZHOU Xin ，KANG Xi ，YANG Rongping 1，2
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（1. College of Pharmacy，Southwest University，Chongqing 400715，China；2. College of Pharmacy，Chengdu
University of TCM，Chengdu 611137，China）
ABSTRACT OBJECTIVE：To provide reference for the quality control and evaluation of rice-wine processed Coptidis Rhizoma
decoction piece. METHODS： Taking 17 batches of rice-wine processed Coptidis Rhizoma decoction piece from different
manufacturers as samples，HPLC method was adopted to determine the contents of 4 kinds of alkaloids as epiberberine，coptisine，
palmatine and berberine. The compound weights of epiberberine，berberine，palmatine and berberine were calculated by the
subjective and objective combination weighting method （AHP combined with variation coefficient）. Then the quality evaluation
method was used to evaluate the quality of decoction pieces combined with the appearance of decoction pieces and the contents of 4
alkaloids. The percent mass constant was calculated and the grade of rice-wine processed Coptidis Rhizoma decoction piece was
classified. RESULTS：According to the results of content determination of 4 kinds of alkaloids，among 17 batches of samples，a
total of 13 batches of samples met the requirements of 2015 edition of Chinese Pharmacopoeia（part Ⅳ）. Mass constants of 13
batches of qualified samples were 10.03-26.96，and the percent mass constants were 37.20％-100％. If the percent mass constant≥
80％ of the sample was listed as the first-class product，the sample with the percent mass constant between 50％ -＜80％ was
classified as the second-class product，and the rest was listed as the third-class product，therefore the quality constant of first-class
product was ≥21.57，that of second-class product was 13.48-＜21.57，and that of third-class product was ＜13.48. According to
the grading standard，3 batches of 13 batches of qualified samples are classified as first-class products，6 batches are classified as
second-class products，4 batches are classified as third-class products. CONCLUSIONS：The established subjective and objective
combination weighting method and quality constant method can more scientifically and reasonably classify rice-wine processed
Coptidis Rhizoma decoction piece.
KEYWORDS Rice-wine processed Coptidis Rhizoma decoction piece；Subjective and objective combination weighting method；
Quality constant；Percent mass constant；Grade evaluation

黄连为毛茛科植物黄连Coptis chinensis Franch.、云 Cheng et Hsiao 的干燥根茎；其药性苦寒，归心、脾、胃、
[1]
连 Coptisteeta Wall 或三角叶黄连 Coptis deltoidea C. Y. 肝、胆、大肠经，主要用于清热燥湿、泻火解毒 。由于黄
连苦寒之性甚强，故临床上多使用其炮制品，主要有姜
Δ 基金项目：国家中药标准化项目（No.ZYBZH-Y-CQ-46）
黄连、萸黄连、酒黄连等。酒炙黄连通过以热制寒，可缓
＊硕士研究生。研究方向：中药新制剂、新剂型及新技术的研究
[2]
解黄连之寒性，且能引药上行，可清头目之火 。现代研
与应用。E-mail：wex8@foxmail.com
# 通信作者：研究员，硕士生导师，博士。研究方向：中药新制剂、 究表明，酒黄连的主要成分为生物碱，如小檗碱、黄连
新剂型及新技术的研究与应用。E-mail：yangrp@cqxndx.com 碱、巴马汀等生物碱，在抗炎、抗肿瘤、抗菌以及降血糖、

中国药房 2020年第31卷第23期 China Pharmacy 2020 Vol. 31 No. 23 ·2853 ·