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生活质量、多重用药、Beers 标准，目前研究的热点包括危险因素、结局指标以及对多重用药的减少策略；形成 Breast cancer、Pre-
scription、Disorder、Schizophrenia、Medication adherence、Trial 等6个聚类；研究前沿是并发症、痛苦、老年衰弱、健康相关质量、认知
障碍。结论：近10年来老年多重用药的研究日趋受到学者的重视，美国以及澳大利亚在该领域的贡献较大；研究主要集中在多重
用药对健康结局的影响以及减少多重用药的策略上；未来可能会更多关注于多重用药对老年心理和认知、衰弱的相关研究。
关键词 老年人；多重用药；文献计量学；Web of Science

Bibliometric Analysis of Research Status and Hotspot Frontier of Polypharmacy in the Elderly
QU Jiling，SHEN Yijing，ZHOU Ting，LIU Yongbing（School of Nursing，Yangzhou University， Jiangsu
Yangzhou 225000，China）

ABSTRACT OBJECTIVE：To analyze the research status and hotspot frontier of polypharmacy in the elderly in recent ten years，
and to provide reference for polypharmacy study in the elderly in China. METHODS：The related literatures about polypharmacy
in the elderly were retireved from Web of Science core database during Jan. 1st，2010-Dec. 31th，2019. CiteSpace 5.6.R5 software
was used to analyze the quantity of pulished literatures，authors，country/area，institution，co-citation of journals and literatures.
The keywords were taken as nodes for co-occurrence analysis，cluster analysis and Burst analysis，the visual maps were drawn and
the results were analyzed. RESULTS：A total of 3 521 literatures were included，and the quantity of published literatures about
polypharmacy in the elderly was on the rise；high-yield authors mainly were Bell JS and Hilmer SN which were the representative
with 36 papers published，accounting for 1.02％ of the total. America（929 literaturesm 26.3％）and University of Sydney（101
literatures，2.87％）were the most high-yield country and institution respectively；Journal of the American Geriatrics Society was
the journal with the most articles（2 202 pieces）. The most frequently cited literature was those published by Radcliff S team in
2015 to update Beers standard to reduce potential inappropriate drug use；the research on how to optimize the prescription for the
elderly published by Spinewine A team in 2007 had the highest co-citation centrality. The hot keywords were elderly，polypharmacy
and risk factor；keywords with high centrality included quality of life，polypharmacy and Beers standard. Research hotspots
included risk factor，outcome index and reduction strategy for polypharmacy. Six clusters were formed，including Breast cancer，
Prescription， Disorder， Schizophrenia， Mediation attachment and Trial； complications， pain， frailty， health-related quality，
intellectual disability were at the forefront of research. CONCLUSIONS：In the past 10 years，the research on polypharmacy in the
elderly has been paid more and more attention by scholars；the United States and Australia have made great contributions in this
field；the research mainly focused on the impact of polypharmacy on health outcomes and the strategies for reduce polypharmacy.
In the future， more attention will be paid to the related research on psychological， cognitive and debilitating effects of
polypharmacy in the elderly.
KEYWORDS Elderly；Polypharmacy；Bibliometrics；Web of Science

目前，全世界老年人口的数量正在增加。随着年龄 相当多的学者和学术期刊集中发表了老年多重用药的
增长，老年人所患慢性病的数量也逐渐增加，多数老年 研究。基于此，本文采用 CiteSpace 软件等对 2010－
[1]
人存在多病共存的状态 ，易导致多重用药 。多重用药 2019 年发表的关于老年多重用药的文献进行可视化分
[2]
是指一个人使用多种药物治疗，一般被定义为使用5种 析，并对当前的研究热点以及现状进行总结，旨在为老
及以上的药物 ，其是应对老年人复杂健康问题的一种 年多重用药的研究提供参考。
[3]
[4]
合理治疗方法 。然而，越来越多的人担心，老年人多重 1 资料与方法
用药，尤其是在复杂的药物组合中会使个别药物之间产 1.1 资料来源及策略
生相反的效果。研究发现，多重用药老年患者中， 以 Web of Science 数据库为检索平台，数据库来源
73.24％的患者存在药物相关问题，接近 60％的药物相 为Web of Science Core Collection，根据医学主题词和自
关问题与治疗有效性相关，且 64.81％的药物相关问题 由词制订检索词与检索策略：（“Older adults”OR“Aged”
对老年人健康存在潜在不利影响 。因此，对于老年人 OR“Elderly”）AND（“Polypharmacy”OR“Polymedica-
[5]
多重用药的研究越来越受到人们的重视。 tion”）。文献类型选择“Acticle”OR“Review”，语种选择
文献计量学是一种定量方法，用于分析科学领域的 “English”，时间年限为 2010 年 1 月 1 日－2019 年 12 月
[6]
文献，并评估研究活动的长期趋势 。过去的 10 年中， 31 日。

中国药房 2020年第31卷第21期 China Pharmacy 2020 Vol. 31 No. 21 ·2665 ·