Page 133 - 2020年20期
P. 133
与了人体其他的生理过程,故开发特异性抗血小板药物 [14] GARDINER EE,SHEN Y. Glycoprotein Ⅰb-Ⅸ-Ⅴ[J]. Int
也是非常重要的。与此同时,作用于血小板聚集多个靶 J Biochem Cell Biol,2003,35(8):1170-1174.
点的药物也可能是未来抗血小板药物研究的方向之一, [15] SCULLY M,CATALAND SR,PEYVANDI F,et al. Ca-
了解血小板激活聚集的机制和相关信号通路可为其研 placizumab treatment for acquired thrombotic thrombocy-
topenic purpura[J]. N Engl J Med,2019,380(4):335-
究提供切入点。
346.
参考文献
[16] PEYVANDI F,SCULLY M,KREMER HOVINGA JA,
[ 1 ] KOUPENOA M,CLANCY L,CORKERY HA,et al. Cir-
et al. Caplacizumab treatment for acquired thrombotic
culating platelets as mediators of immunity,inflammation,
thrombocytopenic purpura[J]. N Engl J Med,2016,374
and thrombosis[J]. Circ Res,2018. DOI:10.1161/CIR-
(6):511-522.
CRESAHA.117.310795.
[17] LEI X,REHEMAN A,HOU Y,et al. Anfibatide,a novel
[ 2 ] UNGERER M,MÜNCH G. Novel antiplatelet drugs in
GPⅠb complex antagonist,inhibits platelet adhesion and
clinical development[J]. Thromb Haemost,2013,109(11):
thrombus formation in vitro and in vivo in murine models
868-875.
of thrombosis[J]. Thromb Haemost,2014,111(2):279-
[ 3 ] CARRERAS ET,MEGA JL. Dual antiplatelet therapy for
289.
heart disease[J]. Circulation,2014,129(21):506-508.
[18] DANE K,CHATURVEDI S. Beyond plasma exchange:
[ 4 ] METHAROM P,BERNDT MC,BAKER RI,et al. Cur-
novel therapies for thrombotic thrombocytopenic purpu-
rent state and novel approaches of antiplatelet therapy[J].
ra[J]. Hematology Am Soc Hematol Educ Program,2018.
Arterioscler Thromb Vasc Biol,2015,35(6):1327-1338. DOI:10.1182/asheducation-2018.1.539.
[ 5 ] RAINGER GE,CHIMEN M,HARRISON MJ,et al. The
[19] XU XR,CARRIM N,NEVES MA,et al. Platelets and
role of platelets in the recruitment of leukocytes during
platelet adhesion molecules:novel mechanisms of throm-
vascular disease[J]. Platelets,2015,26(6):507-520.
bosis and anti-thrombotic therapies[J]. Thromb J,2016.
[ 6 ] KNOWLES RB,WARNER TD. Anti-platelet drugs and DOI:10.1186/s12959-016-0100-6.
their necessary interaction with endothelial mediators and [20] 李盼,乔建林,徐开林.血小板受体GPⅥ作为抗血栓靶点
platelet cyclic nucleotides for therapeutic efficacy[J].
的研究进展[J].中国实验血液学杂志,2017,25(1):
Pharmacol Ther,2019. DOI:10.1016/j.pharmthera.2018. 264-269.
08.004. [21] UNGERER M,ROSPORT K,BÜLTMANN A,et al. Nov-
[ 7 ] VARGA-SZABO D,PLEINES I,NIESWANDT B.Cell ad- el antiplatelet drug revacept(dimeric glycoprotein Ⅵ-Fc)
hesion mechanisms in platelets[J]. Arterioscler Thromb specificallcy and efficiently inhibited collagen-induced
Vasc Biol,2008,28(3):403-412. platelet aggregation without affecting general hemostasis
[ 8 ] TOMAIUOLO M,BRASS LF,STALKER TJ. Regulation in humans[J]. Circulation,2011,123(17):1891-1899.
of platelet activation and coagulation and its role in vascu- [22] BHATTI M,AYTON S,MICHAIl O,et al. Effect of Bru-
lar injury and arterial thrombosis[J]. Interv Cardiol Clin, ton’s tyrosine kinase inhibitors on platelet aggregation in
2017,6(1):1-12. patients with acute myocardial infarction[J]. Thromb Res,
[ 9 ] JURK K,KEHREL BE. Platelets:physiology and bio- 2019. DOI:10.1016/j.thromres.2019.04.024.
chemistry[J]. Semin Thromb Hemost,2005,31(4):381- [23] MANGIN PH,TANG C,BOURDON C,et al. A human-
392. ized glycoprotein Ⅵ(GPⅥ)mouse model to assess the an-
[10] CHEN Y,RUGGERI ZM,DU X. 14-3-3 proteins in plate- tithrombotic efficacies of anti-GPⅥ agents[J]. J Pharma-
let biology and glycoprotein Ⅰb-Ⅸ signaling[J]. Blood, col Exp Ther,2012,341(1):156-163.
2018,131(22):2436-2448. [24] SCHULTE V,REUSCH HP,POZGAJOVÁ M,et al.
[11] DA SILVA ML,O’CONNOR MN,KRISTON-VIZI J,et Two-phase antithrombotic protection after anti-glycopro-
al. Type Ⅱ PI4-kinases control Weibel-Palade body bio- tein Ⅵ treatment in mice[J]. Arterioscler Thromb Vasc Bi-
genesis and von Willebrand factor structure in human en- ol,2006,26(7):1640-1647.
dothelial cells[J]. J Cell Sci,2016,129(10):2096-2105. [25] INDURUWA I,JUNG SM,WARBURTON EA. Beyond
[12] RIVERA J,LOZANO ML,NAVARRO-NUNEZ L,et al. antiplatelets:the role of glycoprotein Ⅵ in ischemic
Platelet receptors and signaling in the dynamics of throm- stroke[J]. Int J Stroke,2016,11(6):618-625.
bus formation[J]. Haematologica,2009,94(5):700-711. [26] 李瀚文,季晖,胡庆华.嘌呤受体P2Y在免疫炎症中的功
[13] CORDINA SM. Novel therapies in the pipeline:directions 能研究进展[J].药学研究,2019,38(4):218-224.
of research into platelet inhibition[J]. J Vasc Interv Neu- [27] GURBEL PA,JEONG YH,NAVARESE EP,et al. Plate-
rol,2008,1(2):54-56. let-mediated thrombosis:from bench to bedside[J]. Circ
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