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吸入疗法治疗呼吸系统疾病的文献可视化分析 Δ

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刘 冲 ，乔高星，楚尧娟，苏 冉，赵 杰，杜书章（郑州大学第一附属医院药学部，郑州 450052）
中图分类号 R974 文献标志码 A 文章编号 1001-0408（2020）13-1622-06
DOI 10.6039/j.issn.1001-0408.2020.13.15

摘 要 目的：探究吸入疗法治疗呼吸系统疾病的全球研究现状和研究热点，为我国未来该领域的进一步发展提供参考。方法：
检索Web of Science数据库中自建库起至2020年1月1日的有关吸入疗法治疗呼吸系统疾病的所有文献。运用Web of Science自
带的检索结果分析功能并结合CiteSpace 5.1.R6SE软件的可视化分析功能，分别从年发文量、国家、机构、学科类别、共被引作者等
方面分析该领域的研究情况；对关键词绘制知识图谱，并进行聚类分析和突发性探测，分析该领域的研究热点及发展进程。结果：
共纳入1 385篇文献。1947－2020年的年发文量总体呈上升趋势；开展相关研究的国家有66个，美国处于领先地位（发文量占总
发文量的 33.79％），其次为德国和英国（发文量分别占总发文量的 10.32％、8.88％），而我国在该领域的发文量仅占总发文量的
3.75％；参与该类研究的机构涉及了呼吸疾病研究所、综合性大学和国家职业安全卫生研究所，其中排名靠前的主要为悉尼大学、
北卡罗来纳大学、哈佛大学等；涉及学科类别包括分子生物学、内科学、药理学、工程学等多个领域；共被引作者共有749位，排名
前2位的作者的共被引频次分别为109、84次。通过聚类分析得到了该领域中包括吸入给药的剂型及工艺设计、吸入用药物作用
机制、吸入疗法用于呼吸系统阻塞性疾病、吸入疗法用于呼吸系统感染性疾病、吸入疗法用于呼吸系统疾病的特殊人群、吸入疗法
用于呼吸系统疾病的危险因素等6大研究热点。通过突发性探测发现，在20世纪90年代初期该领域研究非常活跃，接连出现了
多个研究热点。在21世纪初期也短暂地出现了几个新的研究热点，如计量吸入器、气溶胶等，至21世纪20年代，相继出现了纳米
粒子、人体试验等研究热点。结论：吸入疗法治疗呼吸系统疾病的研究在国际上一直呈稳步上升趋势，而我国在该领域的研究还
十分有限。未来我国可关注国际上该领域的研究热点与方向，进一步加强与其他国家的交流与合作。
关键词 吸入疗法；呼吸系统疾病；研究热点；发展进程；文献可视化分析
Document Visualization Analysis of Inhalation Therapy for Respiratory Diseases
LIU Chong，QIAO Gaoxing，CHU Yaojuan，SU Ran，ZHAO Jie，DU Shuzhang（Dept. of Pharmacy，the First
Affiliated Hospital of Zhengzhou University，Zhengzhou 450052，China）

ABSTRACT OBJECTIVE：To investigate the research status and hotspots of inhalation therapy for respiratory diseases in the
world，and to provide reference for further development of the filed in China. METHODS：All literatures about inhalation therapy
for respiratory disease were retrieved from Web of Science database from the inception to Jan. 1st，2020. The retrieval result
analysis function of Web of Science combined with visual analysis function of CiteSpace 5.1.R6SE software were used to analyze
included literatures from respective of annual number of articles published，countries，institutions，categories and co-cited authors，
so as to analyze the research situation in this field. The knowledge map of key words was drawn，then cluster analysis and burst
detection were carried out，and the research hotspot and development process were analyzed. RESULTS：A total of 1 385 literatures
were included. From 1947 to 2020，the overall trend of annual number of articles published was on the rise. There were 66
countries involved in relevant research，the United States was in the leading position（the number of articles published accounting
for 33.79％ of total articles published），followed by Germany and UK（the number of articles published accounting for 10.32％，
8.88％ of total articles published），while Chinese number of articles published accounting for only 3.75％ of total articles
published. Institutions involved in this research field included the respiratory diseases research institution， comprehensive
universities and national institute for occupational safety health；top ranked institutions were Sydney University，North Carolina
University， Harvard University， etc. The subject category involved molecular biology， internal medicine， pharmacology，
engineering and other fields. A total of 749 authors were co-cited，and the co-cited frequency of top two authors were 109，84
times respectively. Through the cluster analysis，6 major researches hotspots were obtained in this field，including the dosage form
and technology design of inhaled drugs，the mechanism of inhaled drugs，the application of inhalation therapy for the obstructive
diseases of respiratory system，the application of inhalation therapy for the infectious diseases of respiratory system，the application
of inhalation therapy for the special population of respiratory
Δ 基金项目：国家重点研发计划精准医学研究重点专项项目
diseases，and the risk factors in the application of inhalation
（No.2017YFC0909900）
therapy for respiratory diseases. Through the sudden detection，
＊主管药师，硕士。研究方向：临床药理学、制药工程。电话：
0371-66862018。E-mail：liuchong121212@163.com it was found that in the early 1990s，the research in this field
# 通信作者：主任药师。研究方向：循证医学、药物经济学。电 was very active，and there were many research hotspots；in
话：0371-66862018。E-mail：dushuzhang911@163.com the early 21st century， there were several new research

·1622 · China Pharmacy 2020 Vol. 31 No. 13 中国药房 2020年第31卷第13期