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基于中医传承辅助平台的肺结节病方药规律分析 Δ

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刘城鑫 ，洪海都 ，吴 鹏 ，施妙璇 ，詹少锋 ，刘小虹 （1.广州中医药大学第一临床医学院，广州 510006；2.
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广州中医药大学第一附属医院呼吸科，广州 510504）
中图分类号 R256；R287 文献标志码 A 文章编号 1001-0408（2020）08-0975-05
DOI 10.6039/j.issn.1001-0408.2020.08.14
摘 要 目的：为提高肺结节病的中医治疗水平提供参考。方法：计算机检索肺结节病中医治疗的名医经验，整理验案、验方，并
录入中医传承辅助平台V2.5进行数据分析，统计药物频次。运用Apriori算法及关联规则对处方核心组合进行统计分析（设支持
度为16，置信度为0.65）；根据复杂系统熵聚类法提取内在核心组合和新方组合（设相关度为6，惩罚度为2）。结果：共录入25篇文
献，共计64首验方，涉及166味中药材。治疗肺结节病的组方中，单味药物频次由高到低依次是贝母、甘草、黄芪、夏枯草、牡蛎、当
归、半夏、川芎、白芥子等；药物模式多以益气化痰、散结豁痰、补气活血、行气软坚为主要配伍，如“甘草，贝母”“黄芪，贝母”“黄芪，
甘草”等；挖掘出药物内在核心组合10个，如紫背天葵-红景天-柴胡、鹿角-威灵仙-水牛角等；得新方5首，分别为紫背天葵-红景天-
柴胡-谷芽、鹿角-威灵仙-水牛角-滑石、当归-川芎-桑白皮-白芥子-夏枯草-灵芝、白花蛇舌草-桃仁-瓜蒌-牛膝-土鳖虫-桂枝、牛膝-土
鳖虫-麻黄-郁金-姜黄-天竺黄。结论：现代医家多认为痰瘀互结是肺结节病的主要病机，治疗多从肺脾肝肾论治，消癥豁痰、化瘀
软坚之中又重视顾护患者正虚之本，中医药治疗肺结节病具有良好的前景。
关键词 肺结节病；中医药；数据挖掘；中医传承辅助平台；方药规律
Analysis of the Rules of Pulmonary Nodule Prescriptions Based on TCMISS
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LIU Chengxin ，HONG Haidu ，WU Peng ，SHI Miaoxuan ，ZHAN Shaofeng ，LIU Xiaohong（1. College of First
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Clinical Medical，Guangzhou University of TCM，Guangzhou 510006，China；2. Dept. of Respiration，the First
Affiliated Hospital of Guangzhou University of TCM，Guangzhou 510504，China）
ABSTRACT OBJECTIVE： To provide reference for improving TCM treatment of pulmonary nodule. METHODS： The
experience of famous TCM doctors in the TCM treatment of pulmonary nodule was searched by computer，the formulations of the
cases were sorted out，and the data were recorded into the TCMISS V2.5 for data analysis，and the medicine frequency was
counted. Apriori algorithm and association rules were used for statistical analysis of core combination of formulations （support
degree was 16，confidence degree was 0.65）. Inner core combination and new combination were extracted according to the entropy
clustering method of complex system（correlation was 6，penalty was 2）. RESULTS：A total of 25 literatures were input，including
64 formulations in total，166 medicinal materials. For the prescriptions of pulmonary nodule，the frequency of single ingredient
from high to low was Bolbostemma paniculatum，Glycyrrhiza uralensis，Astragalus membranaceus，Prunella vulgaris，Ostrea
gigas，Angelica sinensis，Pinellia ternate，Ligusticum chuanxiong，Mori Corlex，etc. The main compatibility of the drug model is
to invigorate Qi，dissipate phlegm，invigorate Qi and activate blood circulation，and promote Qi and softness，such as“G.
uralensis，B. paniculatum”“A. membranaceus，B. paniculatum”“A. membranaceus，G. uralensis”，etc；10 core combinations of
the drug were found out， such as Begonia fimbristipula-Rhodiola rosea-Bupleurum Chinense， Cervus elaphus Clematis
chinensis-Buffalo Horn，etc. There were 5 new prescriptions，i.e. B. fimbristipula-R. rosea-B. chinense-Setaria italic，C. elaphus-C.
chinensis-Buffalo Horn-French chalk，A. sinensis-L. chuanxiong-Morus alba-Mori Corlex-P. vulgaris-Ganoderma lucidum，Hedyotis
diffusa-Prunus persica-Trichosanthes kirilowii-Achyranthes bidentata-Eupolyphaga sinensis-Cinnamomi Ramulus，A. bidentata-E.
sinensis-Ephedra sinica-Curcuma aromatica-Curcuma longa-Concretio silicea. CONCLUSIONS：Most modern doctors believe that
the interaction of phlegm and blood stasis is the main pathogenesis of pulmonary nodule，and the treatment is mainly based on the
treatment of lung，spleen，liver and kidney，focus on the elimination of symptoms and phlegm，the elimination of blood stasis and
the soft and hard treatment，pay attention to the weak body of the patient. TCM treatment of pulmonary nodule has a good prospect.
KEYWORDS Pulmonary nodule； Traditional Chinese
Δ 基金项目：广东省科技创新战略专项资金项目（No.2018A030310-
medicine；Data mining；TCMISS；Prescription rules
520）；广东省名中医传承工作室建设项目（No.粤中医办函〔2018〕5
号）；广东省名优中成药二次开发项目（No.20174007）；广东大学生科
技创新培育专项（No.pdjh2019b0118）
肺结节病是以肺部非干酪性上皮样肉芽肿为病理
＊硕士研究生。研究方向：中医药防治呼吸系统疾病。E-mail：
表现的肺部疾病，患者早期无症状，多经影像学检查发
1141637223@qq.com
现。该病影像学表现为直径≤3 cm 的局灶性、类圆形、
# 通信作者：主任医师，教授，博士生导师。研究方向：中医药防
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治呼吸系统疾病。E-mail：rsclxh@gzucm.edu.cn 密度增高的实性或亚实性肺部阴影 。其预后大多良
中国药房 2020年第31卷第8期 China Pharmacy 2020 Vol. 31 No. 8 ·975 ·