Page 76 - 2019年9月第30卷第18期

均显著低于红水高组（P＜0.05或P＜0.01）。结论：5味山姜属中药的不同极性部位对胃溃疡寒证模型大鼠具有不同程度的改善作
用，其中红豆蔻最佳，高良姜次之；上述中药均可通过增加17-OHCS、CAs、D-β-H的含量来调节交感神经-肾上腺系统的机能。
关键词 山姜属中药；极性部位；胃溃疡寒证；交感神经-肾上腺系统；机能；大鼠

Effects of Different Polar Parts of 5 Kinds of Alpinia on Function of Sympathetic-adrenal System in
Gastric Ulcer Model Rats with Cold Syndrome
LIU Junhui，QIU Haibing，XIE Peng，SU Shanmei，LI Mingfang，CHEN Junqi，YIN You，QIN Huazhen（College
of Pharmacy，Guangxi University of TCM，Nanning 530200，China）

ABSTRACT OBJECTIVE： To investigate the effects of different polar parts of 5 kinds of Alpinia on the function of
sympathetic-adrenal system in gastric ulcer model rats with cold syndrome，such as the root of Alpinia officinarum，the rhizome
and fruit of Alpinia galangal，the seed of Alpinia katsumadai，and the fruit of Alpinia oxyphylla. METHODS：SD rats were given
Anemarrhena asphodeloides decoction at 4 ℃ and Glacial acetic acid solution intragastrically to induce gastric ulcer model with
cold syndrome；the model rats were randomly divided into model group，Fuzi lizhong pills group（positive control，9.0 g/kg），
cimetidine group（positive control，0.003 3 g/kg），low-dose and high-dose groups of petroleum ether，ethyl acetate，n-butanol and
water extraction parts from 5 medicinal materials （hereinafter referred to as “gaoshidi”“gaoshigao”“dashidi”“dashigao”
“hongshidi”“hongshigao”“caoshidi”“caoshigao”“yishidi”“yishigao”“gaoyidi”“gaoyigao”“dayidi”“dayigao”“hongyidi”
“hongyigao”“caoyidi”“caoyigao”“yiyidi”“yiyigao”“gaozhengdi”“gaozhenggao”“dazhengdi”“dazhenggao”“hongzhengdi”
“hongzhenggao”“caozhengdi”“caozhenggao”“yizhengdi”“yizhenggao”“gaoshuidi”“gaoshuigao”“dashuidi”“dashuigao”
“hongshuidi”“hongshuigao”“caoshuidi”“caoshuigao”“yishuidi”“yishuigao”，0.064/0.256，0.032/ 0.128，0.008/0.032，0.075/0.3，
0.1/0.4，0.064/0.256，0.108/0.432，0.16/0.64，0.064/0.25，0.125/0.5，0.056/0.224，0.108/0.432，0.08/0.32，0.2/0.8，0.3/1.2，0.14/0.56，
0.032/0.128，0.028/0.112，0.05/0.2，0.087/0.348 g/kg，by mass of extraction parts），with 10 rats in each group；and the blank
group（normal temperature water）was set up. Next day after modeling，blank group and model group were given constant volume
of normal temperature water intragastrically；administration group was given relevant solution 2 mL/100 g intragastrically，q12 h，
4 times in total. After last medication，urine contents of 17-OHCS，CAs substances（A，NE，DA）and serum contents of ACTH
and D-β-H were determined by ELISA. RESULTS：Compared with blank group，the contents of 17-OHCS，A，NE and DA in
urine，the contents of ACTH and D-β-H in serum were decreased significantly in model group（P＜0.01）. Compared with model
group，the contents of 17-OHCS （Fuzi lizhong pills group，cimetidine group，gaoshidi，gaoshigao，dashigao，hongshigao，
caoshigao and yishigao groups，ethyl acetate part groups of 5 medicinal materials，dazhenggao，hongzhenggao，caozhenggao and
yizhenggao groups，gaoshuigao，dashuigao and hongshuigao groups），A（Fuzi lizhong pills group，cimetidine group，gaoshigao，
dashigao，hongshidi，hongshigao，caoshidi，caoshigao and yishigao groups，ethyl acetate part groups of 5 medicinal materials，
gaozhenggao，dazhenggao，hongzhengdi，hongzhenggao，caozhenggao and yizhenggao groups，hongshuigao group），NE（Fuzi
lizhong pills group，cimetidine group，petroleum ether part，ethyl acetate part and n-butanol part groups of 5 medicinal materials，
gaoshuigao，dashuigao and hongshuigao groups），DA [Fuzi lizhong pills group，cimetidine group，petroleum ether part（except for
gaoshidi group）and ethyl acetate part groups of 5 medicinal materials，gaozhenggao，dazhenggao，hongzhenggao，caozhenggao
and yizhenggao groups，hongshuigao group] in urine，serum contents of ACTH [Fuzi lizhong pills group，petroleum ether part
（except for gaoshidi，dashidi and caoshidi groups）and ethyl acetate part（except for dayidi and hongyidi groups）groups of 5
medicinal materials， hongzhenggao group， dashuigao group]， and D-β-H [Fuzi lizhong pills group， gaoshigao， dashigao，
hongshidi，hongshigao and yishigao groups，ethyl acetate part groups of 5 medicinal materials（except for dayidi，hongyidi and
yiyidi groups），dazhenggao and hongzhenggao groups，hongshuigao group] were increased significantly（P＜0.05 or P＜0.01）.
The contents of 17-OHCS and D-β-H in dashigao group，the contents of ACTH and D-β-H in caoshigao group and the contents of
D-β-H in gaoshigao and yishigao groups were significantly lower than hongshigao group. The contents of DA in gaoyigao，caoyigao
and yiyigao groups as well as the contents of D-β-H in gaoyigao，hongyigao，caoyigao and yiyigao groups were significantly lower
than dayigao group；the contents of DA in gaoyigao and caoyigao groups were significantly lower than hongyigao group，the
contents of ACTH in gaoyigao，dayigao，caoyigao and yiyigao groups were significantly higher than hongyigao group. The contents
of 17-OHCS， DA and ACTH in gaozhenggao， dazhenggao， caozhenggao and yizhenggao groups， the contents of A in
dazhenggao，caozhenggao and yizhenggao groups as well as the contents of D-β-H in gaozhenggao，caozhenggao and yizhenggao
groups were significantly lower than hongzhenggao group. The contents of 17-OHCS and D-β-H in caoshuigao and yishuigao
groups were significantly lower than dashuigao group. The contents of 17-OHCS，DA and D-β-H in caoshuigao and yishuigao
groups as well as the contents of DA and D-β-H in gaoshuigao groups were significantly lower than hongshuigao group（P＜0.05 or
P＜0.01）. CONCLUSIONS：Different polar parts of 5 kinds of Alpinia can improve gastric ulcer model rats with cold syndrome to
different extents；among them，the fruit of A. galangal is the best，followed by the root of A. officinarum. Above medicinal
materials can regulate the function of sympathetic-adrenal system by increasing the contents of 17-OHCS，CAs and D-β-H.
KEYWORDS Alpinia；Polar part；Gastric ulcer with cold syndrome；Sympathetic-adrenal system；Function；Rat

中国药房 2019年第30卷第18期 China Pharmacy 2019 Vol. 30 No. 18 ·2519 ·