Page 146 - 《中国药房》2026年5期
P. 146

[31]  HAO Y S,CHAPUY B,MONTI S,et al. Selective JAK2     date on development of small-molecule STAT3 inhibitors
               inhibition  specifically  decreases  Hodgkin  lymphoma  and   for cancer therapy:from phosphorylation inhibition to pro‐
               mediastinal large B-cell lymphoma growth in vitro and in   tein  degradation[J].  J  Med  Chem,2021,64(13):8884-
               vivo[J]. Clin Cancer Res,2014,20(10):2674-2683.     8915.
          [32]  PAN Y R,CHEN C C,CHAN Y T,et al. STAT3-coordi‐  [42]  LI X,WEI Y Q,WEI X W. Napabucasin,a novel inhibitor
               nated  migration  facilitates  the  dissemination  of  diffuse   of STAT3,inhibits growth and synergises with doxorubi‐
               large  B-cell  lymphomas[J].  Nat  Commun,2018,9(1):  cin  in  diffuse  large  B-cell  lymphoma[J].  Cancer  Lett,
               3696.                                               2020,491:146-161.
          [33]  LAI P S,ROSA D A,MAGDY ALI A,et al. A STAT in‐  [43]  TOLCHER  A,FLAHERTY  K,SHAPIRO  G  I,et  al.  A
               hibitor patent review:progress since 2011[J]. Expert Opin   first-in-human  phase  I  study  of  OPB-111077,a  small-
               Ther Pat,2015,25(12):1397-1421.                     molecule STAT3 and oxidative phosphorylation inhibitor,
          [34]  WANG H Q,MAN Q W,HUO F Y,et al. STAT3 pathway      in patients with advanced cancers[J]. Oncologist,2018,23
               in cancers:past,present,and future[J]. MedComm,2022,  (6):658-e72.
               3(2):e124.                                     [44]  REILLEY M J,MCCOON P,COOK C,et al. STAT3 anti‐
          [35]  PHILIPS R L,WANG Y X,CHEON H,et al. The JAK-       sense  oligonucleotide  AZD9150  in  a  subset  of  patients
               STAT pathway at 30:much learned,much more to do[J].   with  heavily  pretreated  lymphoma:results  of  a  phase  1b
               Cell,2022,185(21):3857-3876.                        trial[J]. J Immunother Cancer,2018,6(1):119.
          [36]  MATSUOKA Y,NAKAYAMA H,YOSHIDA R,et al. IL-    [45]  ROSCHEWSKI  M,PATEL  M  R,REAGAN  P  M,et  al.
               6 controls resistance to radiation by suppressing oxidative   Phase  Ⅰ  study  of  acalabrutinib  plus  danvatirsen
               stress via the Nrf2-antioxidant pathway in oral squamous   (AZD9150)  in  relapsed/refractory  diffuse  large  B-cell
               cell  carcinoma[J].  Br  J  Cancer,2016,115(10):1234-  lymphoma including circulating tumor DNA biomarker as‐
               1244.                                               sessment[J]. Clin Cancer Res,2023,29(17):3301-3312.
          [37]  CHEN Q N,LU C Y,LI D N,et al. CDK1 inhibitor RO-  [46]  RIBRAG  V,LEE  S  T,RIZZIERI  D,et  al.  A  phase  1b
               3306 enhances BTKi potency in diffuse large B-cell lym‐  study to evaluate the safety and efficacy of durvalumab in
               phoma  by  suppressing  JAK2/STAT3  signaling[J].  Int  J   combination with tremelimumab or danvatirsen in patients
               Biol Macromol,2025,297:139893.                      with relapsed or refractory diffuse large B-cell lymphoma
          [38]  TURKSON J,KIM J S,ZHANG S M,et al. Novel pepti‐    [J].  Clin  Lymphoma  Myeloma  Leuk,2021,21(5):309-
               domimetic inhibitors of signal transducer and activator of   317.e3.
               transcription  3  dimerization  and  biological  activity[J].   [47]  HINTERNDORFER M,SPITERI V A,CIULLI A,et al.
               Mol Cancer Ther,2004,3(3):261-269.                  Targeted  protein  degradation  for  cancer  therapy[J].  Nat
          [39]  SIDDIQUEE K A Z,GUNNING P T,GLENN M,et al.         Rev Cancer,2025,25(7):493-516.
               An oxazole-based small-molecule STAT3 inhibitor modu‐  [48]  ZHOU  J  J,TISON  K,ZHOU  H  B,et  al.  STAT5  and
               lates  STAT3  stability  and  processing  and  induces  antitu‐  STAT3 balance shapes dendritic cell function and tumour
               mor  cell  effects[J].  ACS  Chem  Biol,2007,2(12):  immunity[J]. Nature,2025,643(8071):519-528.
               787-798.                                       [49]  WANG  Z  J,LIAO  X  T,HE  H  Q,et  al.  Targeting  the
          [40]  JING  N  J,ZHU  Q  Q,YUAN  P,et  al.  Targeting  signal   STAT3 pathway with STAT3 degraders[J]. Trends Pharma‐
               transducer and activator of transcription 3 with G-quartet   col Sci,2024,45(9):811-823.
               oligonucleotides:a  potential  novel  therapy  for  head  and   (收稿日期:2025-08-18  修回日期:2026-02-25)
               neck cancer[J]. Mol Cancer Ther,2006,5(2):279-286.                                 (编辑:孙 冰)
          [41]  DONG J Y,CHENG X D,ZHANG W D,et al. Recent up‐











          · 688 ·    China Pharmacy  2026 Vol. 37  No. 5                               中国药房  2026年第37卷第5期
   141   142   143   144   145   146   147   148