Page 125 - 《中国药房》2025年20期

Kyoto rats[J]. Transl Psychiatry，2025，15：54. promotes cognitive impairment via bile acid metabolism
[25] LAI W T，DENG W F，XU S X，et al. Shotgun metage‐ in major depressive disorder[J]. Transl Psychiatry，2024，
nomics reveals both taxonomic and tryptophan pathway 14（1）：503.
differences of gut microbiota in major depressive disorder [34] KIDD M，MODLIN I M，GUSTAFSSON B I，et al. Lumi‐
patients[J]. Psychol Med，2021，51（1）：90-101. nal regulation of normal and neoplastic human EC cell se‐
[26] MAYNARD C，WEINKOVE D. The gut microbiota and rotonin release is mediated by bile salts，amines，tastants，
ageing[J]. Subcell Biochem，2018，90：351-371. and olfactants[J]. Am J Physiol Gastrointest Liver
[27] RAMSTEIJN A S，JAŠAREVIĆ E，HOUWING D J，et al. Physiol，2008，295（2）：G260-G272.
Antidepressant treatment with fluoxetine during preg‐ [35] ENRIGHT E F，GOVINDARAJAN K，DARRER R，et al.
nancy and lactation modulates the gut microbiome and Gut microbiota-mediated bile acid transformations alter
metabolome in a rat model relevant to depression[J]. Gut the cellular response to multidrug resistant transporter sub-
Microbes，2020，11（4）：735-753. strates in vitro：focus on P-glycoprotein[J]. Mol Pharm，
[28] LIN P，LI D，SHI Y，et al. Dysbiosis of the gut microbiota 2018，15（12）：5711-5727.
and kynurenine（Kyn）pathway activity as potential bio‐ [36] JIANG H Y，LING Z X，ZHANG Y H，et al. Altered fecal
markers in patients with major depressive disorder[J]. Nu‐ microbiota composition in patients with major depressive
trients，2023，15（7）：1752. disorder[J]. Brain Behav Immun，2015，48：186-194.
[29] RUDZKI L，OSTROWSKA L，PAWLAK D，et al. Pro- [37] AIT CHAIT Y，MOTTAWEA W，TOMPKINS T A，et al.
biotic Lactobacillus plantarum 299V decreases kynurenine Evidence of the dysbiotic effect of psychotropics on gut
concentration and improves cognitive functions in patients microbiota and capacity of probiotics to alleviate related
with major depression：a double-blind，randomized，pla‐ dysbiosis in a model of the human colon[J]. Int J Mol Sci，
cebo controlled study[J]. Psychoneuroendocrinology， 2023，24（8）：7326.
2019，100：213-222. [38] XU J Z，TANG M Q，WANG D P，et al. Lactocaseibacil‐
[30] ZHOU M F，FAN Y C，XU L T，et al. Microbiome and lus rhamnosus zz-1 supplementation mitigates depression-
tryptophan metabolomics analysis in adolescent depres‐ like symptoms in chronic stress-induced depressed mice
sion：roles of the gut microbiota in the regulation of via the microbiota-gut-brain axis[J]. ACS Chem Neurosci，
tryptophan-derived neurotransmitters and behaviors in hu‐ 2023，14（6）：1095-1106.
man and mice[J]. Microbiome，2023，11（1）：145. [39] MAKKI K，DEEHAN E C，WALTER J，et al. The impact
[31] SIOPI E，CHEVALIER G，KATSIMPARDI L，et al. of dietary fiber on gut microbiota in host health and di-
Changes in gut microbiota by chronic stress impair the ef‐ sease[J]. Cell Host Microbe，2018，23（6）：705-715.
ficacy of fluoxetine[J]. Cell Rep，2020，30（11）：3682- [40] JIANG Y，SHI L Y，QU Y C，et al. Multi-omics analysis
3690.e6. reveals mechanisms of FMT in enhancing antidepressant
[32] LI H R，ZHU X Q，XU J J，et al. The FXR mediated anti- effects of SSRIs[J]. Brain Behav Immun，2025，126：
depression effect of CDCA underpinned its therapeutic po‐ 176-188.
tentiation for MDD[J]. Int Immunopharmacol，2023，115： （收稿日期：2025-05-24 修回日期：2025-09-04）
109626. （编辑：唐晓莲）
[33] JIA M，FAN Y J，MA Q Y，et al. Gut microbiota dysbiosis

中国药房 2025年第36卷第20期 China Pharmacy 2025 Vol. 36 No. 20 · 2603 ·