Page 137 - 《中国药房》2023年16期
P. 137
其他β受体阻滞剂,奈必洛尔对β1受体的高度选择性和 [11] SELEME V B,MARQUES G L,MENDES A E M,et al.
经NO介导的血管舒张特性,使其具有抗氧化、改善内皮 Nebivolol for the treatment of essential systemic arterial
功能紊乱、对性功能影响较小甚至改善以及对血糖、血 hypertension:a systematic review and meta-analysis[J].
脂代谢无不良影响等优点。除对心率影响较小之外,该 Am J Cardiovasc Drugs,2021,21(2):165-180.
[12] LIU J Y,GUO L N,PENG W Z,et al. Efficacy and safety
药物更适用于一些特殊群体患者,包括性活跃的男性高
of nebivolol in hypertensive patients:a meta-analysis of
血压患者及合并有2型糖尿病、代谢综合征等并发症的
randomized controlled trials[J]. J Int Med Res,2020,48
高血压患者。因此,奈必洛尔用于高血压的临床治疗优
(10):300060520931625.
势明显。
[13] VAZ-DE-MELO R O, GIOLLO-JÚNIOR L T,
参考文献 MARTINELLI D D,et al. Nebivolol reduces central blood
[ 1 ] WILLIAMS B,MANCIA G,SPIERING W,et al. 2018 pressure in stage Ⅰ hypertensive patients:experimental
ESC/ESH guidelines for the management of arterial hyper‐
single cohort study[J]. Sao Paulo Med J,2014,132(5):
tension[J].Eur Heart J,2018,39(33):3021-3104. 290-296.
[ 2 ] FONGEMIE J,FELIX-GETZIK E. A review of nebivolol [14] BORGHI C,ACELAJADO M C,GUPTA Y,et al. Role of
pharmacology and clinical evidence[J]. Drugs,2015,75 nebivolol in the control and management of central aortic
(12):1349-1371. blood pressure in hypertensive patients[J]. J Hum Hyper‐
[ 3 ] CHO K I,JEON D W,AHN H S,et al. Efficacy and tens,2017,31(10):605-610.
safety of nebivolol in Korean patients with hypertension [15] SOANKER R,NAIDU M U,RAJU S B,et al. Effect of
by age and sex:a subanalysis from the BENEFIT-KOREA beta-1-blocker,nebivolol,on central aortic pressure and
study[J]. Clin Hypertens,2021,27(1):9. arterial stiffness in patients with essential hypertension[J].
[ 4 ] ALTIN C,OKYAY K,KIS M. et al. The safety and tole- Indian J Pharmacol,2012,44(3):407-411.
rability of nebivolol in hypertensive patients with coro‐ [16] BASILE J,EGAN B,PUNZI H,et al. Risk of hospitaliza‐
nary artery disease and left ventricular ejection fraction≥ tion for cardiovascular events with β-blockers in hyperten‐
40%:a population-based cohort study[J]. Turk Kardiyol sive patients:a retrospective cohort study[J]. Cardiol
Dern Ars,2022,50(8):568-575. Ther,2018,7(2):173-183.
[ 5 ] ZHAO Y Z,VANHOUTTE P M,LEUNG S W. Vascular [17] HUCK D M,ROSENBERG M A,STAUFFER B L.
nitric oxide:beyond eNOS[J]. J Pharmacol Sci,2015,129 Nebivolol and incident cardiovascular events in hyperten‐
(2):83-94. sive patients compared with nonvasodilatory beta blockers
[ 6 ] NAPOLI C,PAOLISSO G,CASAMASSIMI A,et al. [J]. J Hypertens,2022,40(5):1019-1029.
Effects of nitric oxide on cell proliferation:novel insights [18] MANOLIS A,DOUMAS M,FERRI C,et al.Erectile dys‐
[J]. J Am Coll Cardiol,2013,62(2):89-95. function and adherence to antihypertensive therapy-focus
[ 7 ] SHARP R P,GALES B J. Nebivolol versus other beta on β-blockers[J]. Eur J Intern Med,2020,81:1-6.
blockers in patients with hypertension and erectile dys‐ [19] BRIXIUS K,MIDDEKE M,LICHTENTHAL A,et al. Ni‐
function[J]. Ther Adv Urol,2017,9(2):59-63. tric oxide,erectile dysfunction and beta-blocker treatment
[ 8 ] DUPREZ D A,FLOREA N,DUVAL S,et al. Effect (MR NOED study):benefit of nebivolol versus metopro‐
of nebivolol or atenolol vs. placebo on cardiovascular lol in hypertensive men[J]. Clin Exp Pharmacol Physiol,
health in subjects with borderline blood pressure:the 2007,34(4):327-331.
EVIDENCE study[J]. J Hum Hypertens,2017,32(1): [20] ALDEMIR M,KELEŞ İ,KARALAR M,et al. Nebivolol
20-25. compared with metoprolol for erectile function in males
[ 9 ] DIEHL K J,STAUFFER B L,DOW C A,et al. Chronic undergoing coronary artery bypass graft[J]. Anatol J Car‐
nebivolol treatment suppresses endothelin-1-mediated va‐ diol,2016,16(2):131-136.
soconstrictor tone in adults with elevated blood pressure [21] GÜR Ö,GURKAN S,YUMUN G,et al. The comparison
[J]. Hypertension,2016,67(6):1196-1204. of the effects of nebivolol and metoprolol on erectile dys‐
[10] COATS A,JAIN S. Protective effects of nebivolol from function in the cases with coronary artery bypass surgery
oxidative stress to prevent hypertension-related target [J]. Ann Thorac Cardiovasc Surg,2017,23(2):91-95.
organ damage[J]. J Hum Hypertens,2017,31(6):376-381. [22] GUNGOR G,PERK H,SOYUPEK S,et al. Nebivolol
中国药房 2023年第34卷第16期 China Pharmacy 2023 Vol. 34 No. 16 · 2047 ·