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着重要作用。TNF-α在创面皮肤中具有始动效应,可诱 obese patients by negative pressure wound therapy[J]. J
导 IL-6、IL-1β 的分泌,从而影响血管通透性,进而导致 Thorac Cardiovasc Surg,2013,145(5):1387-1392.
循环障碍 [18―19] 。因此,尽早减少烧伤早期创面中炎症因 [12] KLASEN H J. A review on the nonoperative removal of
子的释放,可以促进烧伤创面的愈合。本研究结果显 necrotic tissue from burn wounds[J]. Burns,2000,26(3):
示,经栀续烫伤膏干预后,大鼠烧伤皮肤组织中TNF-α、 207-222.
[13] DAMIANI G,PINNARELLI L,SOMMELLA L,et al.
IL-1β、IL-6 水平均显著降低,这表明栀续烫伤膏可通过
Vacuum-assisted closure therapy for patients with infected
减轻炎症反应,促进大鼠烧伤皮肤组织愈合。
sternal wounds:a meta-analysis of current evidence[J]. J
综上所述,栀续烫伤膏可修复深Ⅱ度烧伤模型大鼠
Plast Reconstr Aesthet Surg,2011,64(9):1119-1123.
皮肤,其机制可能与减轻烧伤创面炎症反应,促进血管
[14] 陈端凯,冯时,唐乾利,等. 湿润暴露疗法/湿润烧伤膏对
新生有关。
慢性创面组织中MMP-2和MMP-9表达的影响[J]. 中国
参考文献 药理学通报,2020,36(2):288-294.
[ 1 ] JESCHKE M G,PECK M D. Burn care of the elderly[J]. [15] PIERCE G F,TARPLEY J E,ALLMAN R M,et al. Tis‐
J Burn Care Res,2017,38(3):e625-e628. sue repair processes in healing chronic pressure ulcers
[ 2 ] AHN H N,KANG H S,PARK S J,et al. Safety and effi‐ treated with recombinant platelet-derived growth factor
cacy of basic fibroblast growth factors for deep second- BB[J]. Am J Pathol,1994,145(6):1399-1410.
degree burn patients[J]. Burns,2020,46(8):1857-1866. [16] COLLINS R G,VELJI R,GUEVARA N V,et al. P-
[ 3 ] 杨媚月,黄湘俊,刘秀芝,等. 蜈蚣油对中国白兔深Ⅱ度 selectin or intercellular adhesion molecule (ICAM)-1 de‐
烧伤组织中 VEGF、IL-8 表达水平的影响[J]. 护理研究, ficiency substantially protects against atherosclerosis in
2018,32(7):1078-1081. apolipoprotein E-deficient mice[J]. J Exp Med,2000,191
[ 4 ] 王莹,代彦丽,朴金龙,等. 炎症因子、生长因子以及凋亡 (1):189-194.
因子在压疮慢性难愈合性创面中的表达及作用[J]. 中国 [17] EBRAHIMINASERI A,SADEGHIZADEH M,MOSHAII
应用生理学杂志,2017,33(2):181-184,188. A,et al. Combination treatment of dendrosomal nanocur‐
[ 5 ] 杜孟姣,陈坚平,余嘉贤,等. 基于斑马鱼模型的知母皂 cumin and low-level laser therapy develops proliferation
苷BⅡ的血管保护作用及机制研究[J]. 中国药房,2020, and migration of mouse embryonic fibroblasts and alter
31(7):811-815. TGF-β,VEGF,TNF-α and IL-6 expressions involved in
[ 6 ] 靳丽丽,王瑞萍,孙梦,等 . 外源性 VEGF 促进大鼠Ⅱ度 wound healing process[J]. PLoS One,2021,16(5):
烫伤创面中晚期愈合[J]. 中国组织化学与细胞化学杂 e0247098.
志,2019,28(3):221-227. [18] ALHILALI M J,PARHAM A,ATTARANZADEH A,
[ 7 ] 潘翔,韩思婕,陈可琢,等. 复方鳄鱼油烧伤膏对浅Ⅱ度 et al. Prognostic role of follicular fluid tumor necrosis
烧伤皮肤的修复及抗炎镇痛作用[J]. 中国药房,2021,32 factor alpha in the risk of early ovarian hyperstimulation
(20):2467-2472. syndrome[J]. BMC Pregnancy Childbirth,2020,20
[ 8 ] 桑龙燕. 地榆膏对大鼠深Ⅱ度烫伤创面微循环及机体炎 (1):691.
性反应的影响[D]. 合肥:安徽中医药大学,2021. [19] KUNIMURA K,MIKI S,TAKASHIMA M,et al. S-1-pro‐
[ 9 ] 苗明三,王坦,田硕. 烧(烫)伤动物模型制备规范(草案) penylcysteine improves TNF-α-induced vascular endothe‐
[J]. 中国实验方剂学杂志,2017,23(24):11-16. lial barrier dysfunction by suppressing the GEF-H1/RhoA/
[10] REINKE J M,SORG H. Wound repair and regeneration Rac pathway[J]. Cell Commun Signal,2021,19(1):17.
[J]. Eur Surg Res,2012,49(1):35-43. (收稿日期:2022-11-17 修回日期:2023-04-17)
[11] GRAUHAN O,NAVASARDYAN A,HOFMANN M,et (编辑:唐晓莲)
al. Prevention of poststernotomy wound infections in
中国药房 2023年第34卷第11期 China Pharmacy 2023 Vol. 34 No. 11 · 1325 ·