Page 36 - 《中国药房》2022年21期

中药防治心肌缺血再灌注损伤的文献计量学分析 Δ

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祁 祥 ，卢健棋 ，王昱涵 ，武尚志 ，蒋志雄 ，朱智德 ，何晓羚（1.广西中医药大学研究生院，南宁 530200；
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2.广西中医药大学第一附属医院心内科/国家中医心血管病临床医学研究中心分中心，南宁 530200；3.广西中
医药大学药学院，南宁 530200；4.广西中医药大学基础医学院，南宁 530200；5.广西中医药大学博物馆，南
宁 530200）
中图分类号 R932；R-1 文献标志码 A 文章编号 1001-0408（2022）21-2590-07
DOI 10.6039/j.issn.1001-0408.2022.21.06

摘 要 目的 对中药防治心肌缺血再灌注损伤（MIRI）领域的研究现状、热点进行分析，为开展相关研究提供参考依据。方法
以Web of Science中收录的有关中医药治疗MIRI的文献为数据来源，进行文献计量学分析。结果 本研究共计纳入972篇文献。
近10年中药防治MIRI的研究呈现逐年上升趋势，2021年发表的文章被引次数最多；研究者多集中于中国；中国医学科学院北京
协和医学院在该领域发文最多，并与其他机构有着较多的合作，在该领域有着较大的影响力；Sun Guibo与Sun Xiaobo是该领域高
产作者，但全球作者合作并不紧密，尚未形成一定规模的合作团队；Molecular Medicine Reports 可能是该领域最受欢迎的杂志。
共被引分析发现，该领域的研究方向多集中在探索MIRI的发病机制以及找寻干预靶点方面；关键词分析显示，中药调控细胞凋
亡、细胞焦亡、线粒体功能障碍、miRNA等途径改善MIRI的研究是该领域的热点，研究较多的信号通路有Nrf2通路、NF-κB通路、
NLRP3炎症小体通路、TNF通路、SIRT3通路、JNK通路、PI3K/Akt通路、AMPK通路。结论 近10年中药防治MIRI的研究备受关
注，目前该领域的热点多集中于中药有效成分与中成药对MIRI的干预机制研究。此外，中药治疗MIRI的科研现阶段多集中于基
础实验领域，建议未来多开展大规模、高质量、多中心、随机对照的临床研究，以期为中药应用于临床提供高级别循证医学证据。
关键词 中药；心肌缺血再灌注损伤；心血管疾病；文献计量学

Bibliometric analysis of traditional Chinese medicines for myocardial ischemia-reperfusion injury
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QI Xiang ，LU Jianqi ，WANG Yuhan ，WU Shangzhi ，JIANG Zhixiong ，ZHU Zhide ，HE Xiaoling（1. School of
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Graduate，Guangxi University of Chinese Medicine，Nanning 530200，China；2. Dept. of Cardiology，the First
Affiliated Hospital of Guangxi University of Chinese Medicine/Branch Center of National Clinical Medical
Research Center for Cardiovascular Diseases of Traditional Chinese Medicine， Nanning 530200， China；
3. School of Pharmacy，Guangxi University of Chinese Medicine，Nanning 530200，China；4. School of Basic
Medicine，Guangxi University of Chinese Medicine，Nanning 530200，China；5. Museum of Guangxi University
of Chinese Medicine，Nanning 530200，China）
ABSTRACT OBJECTIVE To analyze the current status and research hot spots of traditional Chinese medicine（TCM）in the

prevention and treatment of myocardial ischemia-reperfusion injury （MIRI），and to provide reference for developing relevant
studies. METHODS A bibliometric analysis was performed with the literature on TCM treatments for MIRI included in the Web of
Science as the data source. RESULTS A total of 972 literatures were included in this study. The research on TCM for prevention
and treatment of MIRI in recent 10 years showed an increasing trend year by year，and the literature published in 2021 were cited
most frequently；most research scholars focused in China；Peking Union Medical College，Chinese Academy of Medical Sciences
had the most papers in this field，and a lot of collaboration with other institutions，which had a large influence in the field；Sun
Guibo and Sun Xiaobo were high-yielding authors in the field，but the global authorship was not very close and had not formed
cooperative teams of some scale；Molecular Medicine Reports was perhaps the most popular journal in the field. Co-citation
analysis found that the research direction in this field was mostly focused on exploring the pathogenesis of MIRI and finding
intervention targets. Key words analysis revealed that TCM-
Δ 基金项目 国家自然科学基金资助项目（No.82160887）；广西自
regulated apoptosis， pyroptosis， mitochondrial dysfunction，
然科学基金资助项目（No.2017GXNSFAA198302）
miRNA and other pathways to improve MIRI research was a
＊第一作者 硕士研究生。研究方向：心血管疾病的防治。E-
mail：898710700@qq.com hot spot in the field，and more studies had focused on
# 通信作者 教授，硕士生导师，博士。研究方向：中西医结合防治 the Nrf2 pathway，NF-κB pathway，NLRP3 inflammasome
心血管疾病。E-mail：zzd_15977775151@163.com pathway， TNF pathway， SIRT3 pathway， JNK pathway，

·2590· China Pharmacy 2022 Vol. 33 No. 21 中国药房 2022年第33卷第21期