Page 137 - 《中国药房》2022年18期
P. 137

twenty[J]. Immunity,2012,36(4):503-514.        [22]  MUKHERJEE A,HAZRA A,SMITH M K,et al.
          [ 9 ]  SOENDERGAARD C,BERGENHEIM F H,BJERRUM            Exposure-response characterization of tofacitinib efficacy
              J T,et al. Targeting JAK-STAT signal transduction in IBD  in moderate to severe ulcerative colitis:results from a
              [J]. Pharmacol Ther,2018,192:100-111.               dose-ranging phase 2 trial[J]. Br J Clin Pharmacol,2018,
          [10]  O’SHEA J J,HOLLAND S M,STAUDT L M. JAKs and       84(6):1136-1145.
              STATs in immunity,immunodeficiency,and cancer[J]. N  [23]  SANDBORN W J,GHOSH S,PANES J,et al. Tofaci‐
              Engl J Med,2013,368(2):161-170.                     tinib,an oral Janus kinase inhibitor,in active ulcerative
          [11]  VILLARINO A V,KANNO Y,O'SHEA J J. Mechanisms      colitis[J]. N Engl J Med,2012,367(7):616-624.
              and consequences of JAK-STAT signaling in the immune  [24]  SANDBORN W J,SU C,SANDS B E,et al. Tofacitinib
              system[J]. Nat Immunol,2017,18(4):374-384.          as induction and maintenance therapy for ulcerative colitis
          [12]  MCGOVERN D P,GARDET A,TÖRKVIST L,et al.           [J]. N Engl J Med,2017,376(18):1723-1736.
              Genome-wide association identifies multiple ulcerative  [25]  VERMEIRE S,SU C,LAWENDY N,et al. Outcomes of
              colitis susceptibility loci[J]. Nat Genet,2010,42(4):  tofacitinib dose reduction in patients with ulcerative coli‐
              332-337.                                            tis in stable remission from the randomised RIVETING
          [13]  ANDERSON C A,BOUCHER G,LEES C W,et al. Meta-      trial[J]. J Crohns Colitis,2021,15(7):1130-1141.
              analysis identifies 29 additional ulcerative colitis risk loci,  [26]  SANDS B E,ARMUZZI A,MARSHALL J K,et al. Effi‐
              increasing the number of confirmed associations to 47[J].  cacy and safety of tofacitinib dose de-escalation and dose
              Nat Genet,2011,43(3):246-252.                       escalation for patients with ulcerative colitis:results from
          [14]  JOSTINS L,RIPKE S,WEERSMA R K,et al. Host-        OCTAVE open[J]. Aliment Pharmacol Ther,2020,51(2):
              microbe interactions have shaped the genetic architecture  271-280.
              of inflammatory bowel disease[J]. Nature,2012,491  [27]  PANÉS J,VERMEIRE S,DUBINSKY M C,et al. Effi‐
              (7422):119-124.                                     cacy and safety of tofacitinib re-treatment for ulcerative
          [15]  BOLAND B S,SANDBORN W J,CHANG J T. Update         colitis after treatment interruption:results from the
              on Janus kinase antagonists in inflammatory bowel disease  OCTAVE clinical trials[J]. J Crohns Colitis,2021,15
              [J]. Gastroenterol Clin North Am,2014,43(3):603-617.  (11):1852-1863.
          [16]  FERNÁNDEZ-CLOTET  A, CASTRO-POCEIRO     J,   [28]  PANÉS J,VERMEIRE S,LINDSAY J O,et al. Tofaci‐
              PANÉS J. Tofacitinib for the treatment of ulcerative colitis  tinib in patients with ulcerative colitis:health-related qua-
              [J]. Expert Rev Clin Immunol,2018,14(11):881-892.   lity of life in phase 3 randomised controlled induction and
          [17]  SPALINGER M R,SAYOC-BECERRAA,ORDOOKHANIAN         maintenance studies[J]. J Crohns Colitis,2018,12(2):
              C,et al. The JAK inhibitor tofacitinib rescues intestinal  145-156.
              barrier defects caused by disrupted epithelial-macrophage  [29]  JAMESHORANI M,VAHEDI H,SADEGHI A,et al. Ef‐
              interactions[J]. J Crohns Colitis,2021,15(3):471-484.  ficacy and safety of tofacitinib for treatment of moderate
          [18]  SAYOC-BECERRA A,KRISHNAN M,FAN S J,et al.         to severe active ulcerative colitis:first report from Iran[J].
              The JAK-inhibitor tofacitinib rescues human intestinal epi‐  Arch Iran Med,2021,24(5):354-363.
              thelial cells and colonoids from cytokine-induced barrier  [30]  LAIR-MEHIRI L,STEFANESCU C,VAYSSE T,et al.
              dysfunction[J]. Inflamm Bowel Dis,2020,26(3) :      Real-world evidence of tofacitinib effectiveness and
              407-422.                                            safety in patients with refractory ulcerative colitis[J]. Dig
          [19]  CORDES F,LENKER E,SPILLE L J,et al. Tofacitinib   Liver Dis,2020,52(3):268-273.
              reprograms human monocytes of IBD patients and healthy  [31]  BIEMANS V B C,SLEUTJES J A M,DE VRIES A C,et
              controls toward a more regulatory phenotype[J]. Inflamm  al. Tofacitinib for ulcerative colitis:results of the prospec‐
              Bowel Dis,2020,26(3):391-406.                       tive Dutch Initiative on Crohn and Colitis(ICC)registry
          [20]  DOWTY M E,LIN J Y,RYDER T F,et al. The pharmaco‐  [J]. Aliment Pharmacol Ther,2020,51(9):880-888.
              kinetics,metabolism,and clearance mechanisms of tofaci‐  [32]  UZZAN M,BRESTEAU C,LAHARIE D,et al. Tofaci‐
              tinib,a Janus kinase inhibitor,in humans[J]. Drug Metab  tinib as salvage therapy for 55 patients hospitalised with
              Dispos,2014,42(4):759-773.                          refractory severe ulcerative colitis:a GETAID cohort[J].
          [21]  Pfizer. Pfizer announces U.S. FDA approves Xeljanz(to‐  Aliment Pharmacol Ther,2021,54(3):312-319.
              facitinib)for the treatment of moderately to severely ac‐  [33]  BERINSTEIN J A,SHEEHAN J L,DIAS M,et al. Tofaci‐
              tive ulcerative colitis[EB/OL].(2018-05-30)[2022-02-08].  tinib for biologic-experienced hospitalized patients with
              https://www. pfizer. com/news/press-release/press-release-  acute severe ulcerative colitis:aretrospective case-control
              detail/pfizer_announces_u_s_fda_approves_xeljanz_to ‐  study[J]. Clin Gastroenterol Hepatol,2021,19(10):2112-
              facitinib_for_the_treatment_of_moderately_to_severely_  2120.e1.
              active_ulcerative_colitis-0.                   [34]  SHAFFER S R,HUANG E,PATEL S,et al. Cost-


          中国药房    2022年第33卷第18期                                            China Pharmacy 2022 Vol. 33 No. 18  ·2303·
   132   133   134   135   136   137   138   139   140