Page 54 - 2021年17期
P. 54

pled with system pharmacology reveal the protective ef-  quality control strategy using UHPLC-Q exactive hybrid
             fect of total flavonoids of Astragali Radix against adriamy-  quadrupole-orbitrap high-resolution mass spectrometry[J].
             cin-induced rat nephropathy model[J]. J Pharmaceut  Sci Rep,2017,7(1):16921-16936.
             Biomed,2018,158:128-136.                       [19]  QU T L,LI Z Y,ZHAO S J,et al. A metabonomic analy-
        [ 7 ]  HUANG J,CHEN H Y,LI C Y,et al. Screening and iden-  sis reveals novel regulatory mechanism of Huangqi injec-
             tification of the metabolites of water extracts of raw and  tion on leucopenia mice[J]. Immunopharm Immunot,
             honey-processed astragalus in rat urine based on UHPLC/  2016,38(2):113-123.
             ESI-Q-TOF-MS and multivariate statistical analysis[J]. J  [20]  刘腾,许晋芳,卢晓林,等.基于 LC-MS 代谢组学研究黄
             Am Soc Mass Spectrom,2018,29(9):1919-1935.          芪注射液对白细胞减少症模型小鼠的干预作用[J].中国
        [ 8 ]  ZHANG Y P,NIE M K,SHI S Y,et al. Integration of   药房,2020,31(21):2627-2633.
             magnetic solid phase fishing and off-line two-dimensional  [21]  曲婷丽,王二兵,李震宇,等.黄芪注射液乙酸乙酯萃取物
             high-performance liquid chromatography-diode array de-  对小鼠白细胞减少症作用的代谢组学研究[J].中成药,
             tector-mass spectrometry for screening and identification  2017,39(3):455-461.
             of human serum albumin binders from Radix Astragali[J].  [22]  宫文霞.当归及其活性成分的抗抑郁作用及机制研究[D].
             Food Chem,2014,146:56-64.                           太原:山西大学,2019.
        [ 9 ]  WANG Y M,LIU L,MA Y K,et al. Chemical discrimina-  [23]  CRUMBLEY C,WANG Y J,BANERJEE S,et al. Regula-
             tion of Astragalus mongholicus and Astragalus membrana-  tion of expression of citrate synthase by the retinoic acid
             ceus based on metabolomics using UHPLC-ESI-Q-TOF-   receptor-related orphan receptor α(RORα)[J]. PLoS One,
             MS/MS approach[J]. Molecules,2019,24:4064.          2012,7(4):e33804.
        [10]  LIU P P,SHAN G S,ZHANG F,et al. Metabolomics ana-  [24]  姜清芳,黄敏怡,游春香,等.三七总皂苷和多烯磷脂酰胆
             lysis and rapid identification of changes in chemical ingre-  碱调控大鼠非酒精性脂肪肝的药效学比较[J].中国医药
             dients in crude and processed Astragali Radix by UPLC-  科学,2020,10(21):23-26.
             QTOF-MS combined with novel informatics UNIFI plat-  [25]  师萱,阳勇,秦伟瀚,等.环磷酰胺对小鼠免疫抑制作用过
             form[J]. Chin J Nat Medicines,2018,16(9):714-720.   程中代谢通路变化的代谢组学研究[J].中国实验动物学
        [11]  MEI X D,WANG Y Q,LIU Z H,et al. The chemical trans-  报,2017,25(5):539-543.
             formations for Radix Astragali via different alkaline wash  [26]  陈婧,刘云霞,徐叶峰,等.代谢组学法分析骨髓抑制模型
             conditions by quantitative and qualitative analyses[J]. J  小鼠血清小分子代谢产物[J].色谱,2017,35(12):1312-
             Pharmaceut Biomed,2020,185:113164.                  1316.
        [12]  张友山,闻后钧,刘雪银.黄芪注射液治疗白细胞减少症                     [27]  JI P,WEI Y M,HUA Y L,et al. A novel approach using
             112例临床观察[J].时珍国医国药,2000,11(10):935.                 metabolomics coupled with hematological and biochemi-
        [13]  ZHANG C S,ZHU C T,LING Y,et al. The clinical value  cal parameters to explain the enriching-blood effect and
             of Huangqi injection in the treatment of leucopenia:a me-  mechanism of unprocessed Angelica sinensis and its 4
             ta-analysis of clinical controlled trials[J]. PLoS One,  kinds of processed products[J]. J Ethnopharmacol,2018,
             2013,8(12):e83123.                                  211:101-116.
        [14]  曾小红.黄芪注射液治疗甲巯咪唑引起甲亢患者白细胞                      [28]  MS J P,KHAN S,MPHIL G J. Nicotinamide attenuates
             减少症评价[J].辽宁中医药大学学报,2014,12(16):                     cyclophosphamide-induced hepatotoxicity in SD rats by
             176-178.                                            reducing oxidative stress and apoptosis[J]. J Biochem Mol
        [15]  张扶莉,杨利生.升白方与黄芪注射液治疗化疗后白细胞                          Toxicol,2020,34(10):e22558.
             减少症疗效观察[J].陕西中医,2011,32(8):1023-1024.          [29]  WANG S F,SUN M,YU L,et al. Niacin inhibits apopto-
        [16]  章奇法,葛丹枫,陈晓波,等.穴位注射联合补益生血中药                         sis and rescues premature ovarian failure[J]. Cell Physiol
             治疗白细胞减少症56例疗效观察[J].健康研究,2015,35                     Biochem,2018,50:2060-2070.
             (3):313-314.                                   [30]  BITTERMAN K J,ANDERSON R M,COHEN H Y,
        [17]  高永盛,李燕,符发年.直肠癌新辅助化疗前应用黄芪注                          et al. Inhibition of silencing and accelerated aging by nico-
             射液预防白细胞减少的效果观察[J].中国肛肠病杂志,                          tinamide,a putative negative regulator of yeast sir2 and
             2018,38(5):17-19.                                   human SIRT1[J]. J Biol Chem,2002,277:45099-45107.
        [18]  SUN Z,ZUO L H,SUN T W,et al. Chemical profiling             (收稿日期:2021-03-23  修回日期:2021-06-09)
             and quantification of XueBiJing injection,a systematic                              (编辑:唐晓莲)






        ·2096 ·  China Pharmacy 2021 Vol. 32 No. 17                                 中国药房    2021年第32卷第17期
   49   50   51   52   53   54   55   56   57   58   59