Page 31 - 2021年15期
P. 31

vascular administration after intravenous infusion of  血神经元的保护机制[J].天津中医药,2015,32(7):420-
             thrombolytic agents for the treatment of patients with  423.
             acute ischemic strokes[J]. Neurosurgery,2002,50(2):  [16]  HUANG W,LV B,ZENG H,et al. Paracrine factors se-
             251-260.                                           creted by MSCs promote astrocyte survival associated
        [ 4 ]  LECRUX C,HAMEL E. The neurovascular unit in brain  with GFAP downregulation after ischemic stroke via p38
             function and disease[J]. Acta Physiol(Oxf),2011,203  MAPK and JNK[J]. J Cell Physiol,2015,230(10):2461-
            (1):47-59.                                          2475.
        [ 5 ]  GAO M,ZHU S Y,TAN C B,et al. Pinocembrin protects  [17]  XIANG J,LAN R,TANG Y P,et al. Apocynum venetum
             the neurovascular unit by reducing inflammation and ex-  leaf extract attenuates disruption of the blood-brain barrier
             tracellular proteolysis in MCAO rats[J]. J Asian Nat Prod  and upregulation of matrix metalloproteinase-9/-2 in a rat
             Res,2010,12(5):407-418.                            model of cerebral ischemia-reperfusion injury[J]. Neuro-
        [ 6 ]  ZHANG R,TANG S,HUANG W,et al. Protection of the  chem Res,2012,37(8):1820-1828.
             brain following cerebral ischemia through the attenuation  [18]  SHI Y,JIANG X,ZHANG L,et al. Endothelium-targeted
             of PARP-1-induced neurovascular unit damage in rats[J].  overexpression of heat shock protein 27 ameliorates
             Brain Res,2015,1624:9-18.                          blood-brain barrier disruption after ischemic brain inju-
        [ 7 ]  MOHAMED I N,ISHRAT T,FAGAN S C,et al. Role of    ry[J]. Proc Natl Acad Sci U S A,2017,114(7):E1243-
             inflammasome activation in the pathophysiology of vascu-  E1252.
             lar diseases of the neurovascular unit[J]. Antioxid Redox  [19]  HA P J,YOO K Y,HYE K I,et al. Hydroquinone strongly
             Signal,2015,22(13):1188-1206.                      alleviates focal ischemic brain injury via blockage of
        [ 8 ]  LI Y,CHOPP M,JIANG N,et al. Temporal profile of in  blood-brain barrier disruption in rats[J]. Toxicol Sci,
             situ DNA fragmentation after transient middle cerebral ar-  2016,154(2):430-441.
             tery occlusion in the rat[J]. J Cereb Blood Flow Metab,  [20]  HAGHNEJAD A A,ORYAN S,BOHLOOLI S,et al. Al-
             1995,15(3):389-397.                                pha-tocopherol reduces brain edema and protects blood-
        [ 9 ]  徐芳琴,郭超,卞涛,等.丹红注射液对大鼠脑缺血/再灌                       brain barrier integrity following focal cerebral ischemia in
             注损伤治疗时间窗的影响[J].中成药,2016,38(9):                     rats[J]. Med Princ Pract,2017,26(1):17-22.
             1887-1892.                                    [21]  ENRIQUE Z L,PHILIP R W,SARA C,et al. Reversible
        [10]  肖晗.丹参酮ⅡA在不同时间点给药对大鼠脑缺血模型再                         middle cerebral artery occlusion without craniectomy in
             灌注损伤的神经保护作用研究[D].合肥:安徽医科大学,                        rats[J]. Stroke,1989,20(1):84-91.
             2014.                                         [22]  饶梦琳,唐蜜,何锦悦,等.芍药苷对大鼠局灶性脑缺血再
        [11]  ZONTA M,ANGULO M C,GOBBO S,et al. Neuron-to-      灌注脑血流量及 PGI2/TXA2 平衡的影响[J].药学学报,
             astrocyte signaling is central to the dynamic control of  2014,49(1):55-60.
             brain microcirculation[J]. Nat Neurosci,2003,6(1):43-  [23]  李娜.红花黄色素对控制性低血压诱导的缺血缺氧性脑
             50.                                                损伤的影响及机制研究[D].广州:南方医科大学,2016.
        [12]  SAVCHENKO E S,PEVZNER I B,ZOROVA L D,et al.  [24]  DIRNAGL U. Pathobiology of injury after stroke:the neu-
             Changes in the number of neurons,astrocytes and micro-  rovascular unit and beyond[J]. Ann N Y Acad Sci,2012,
             glia in the brain after ischemic stroke assessed by immuno-  1268:21-25.
             histochemistry and immunoblotting[J]. Tsitologiia,2016,  [25]  YULONG M,HANG G,LIXIA Z,et al. Estrogen replace-
             58(7):534-542.                                     ment therapy-induced neuroprotection against brain is-
        [13]  LI X,XIANG B,SHEN T,et al. Anti-neuroinflammatory  chemia-reperfusion injury involves the activation of astro-
             effect of 3,4-dihydroxybenzaldehyde in ischemic stroke  cytes via estrogen receptor β[J]. Sci Rep,2016,6:21467.
             [J]. Int Immunopharmacol,2020,82:106353.      [26]  WU C,CHEN J,CHEN C,et al. Wnt/beta-catenin cou-
        [14]  DUAN X,WANG W,LIU X,et al. Neuroprotective effect  pled with HIF-1alpha/VEGF signaling pathways involved
             of ethyl acetate extract from gastrodia elata against tran-  in galangin neurovascular unit protection from focal cere-
             sient focal cerebral ischemia in rats induced by middle ce-  bral ischemia[J]. Sci Rep,2015,5:16151.
             rebral artery occlusion[J]. J Tradit Chin Med,2015,35        (收稿日期:2021-02-18  修回日期:2021-05-06)
            (6):671-678.                                                                        (编辑:唐晓莲)
        [15]  王慧钢,于思淼,邱瑾,等. SUMO-2/3活化介导丹参对缺






        中国药房    2021年第32卷第15期                                             China Pharmacy 2021 Vol. 32 No. 15  ·1817 ·
   26   27   28   29   30   31   32   33   34   35   36