Page 85 - 2020年1月第31卷第2期
P. 85

diabetes mellitus in pancreatic cancer compared to com-  [15]  WANG YW,HE SJ,FENG X,et al. Metformin:a review
             mon cancers[J]. Pancreas,2013,42(2):198-201.       of its potential indications[J]. Drug Des Devel Ther,
        [ 3 ]  ELENA JW,STEPLOWSKI E,YU K,et al. Diabetes and   2017. DOI:10.2147/DDDT.S141675.
             risk of pancreatic cancer:a pooled analysis from the pan-  [16]  NAIR V,PATHI S,JUTOORU I,et al. Metformin inhibits
             creatic cancer cohort consortium[J]. Cancer Causes Con-  pancreatic cancer cell and tumor growth and downregu-
             trol,2013,24(1):13-25.                             lates SP transcription factors[J]. Carcinogenesis,2013,34
        [ 4 ]  CHOI Y,KIM TY,OH DY,et al. The impact of diabetes  (12):2870-2879.
             mellitus and metformin treatment on survival of patients  [17]  GONG J,ROBBINS LA,LUGEA A,et al. Diabetes,pan-
             with advanced pancreatic cancer undergoing chemothera-  creatic cancer,and metformin therapy[J]. Front Physiol,
             py[J]. Cancer Res Treat,2016,48(1):171-179.        2014. DOI:10.3389/fphys.2014.00426.
        [ 5 ]  XIN W,FANG L,FANG Q,et al. Effects of metformin on  [18]  DE SOUZA A,KHAWAJA KI,MASUD F,et al. Metfor-
             survival outcomes of pancreatic cancer patients with dia-  min and pancreatic cancer:is there a role? [J]. Cancer
             betes:a meta-analysis[J]. Mol Clin Oncol,2018,8(3):  Chemother Pharmacol,2016,77(2):235-242.
             483-488.                                      [19]  INCIO J,SUBOJ P,CHIN SM,et al. Metformin reduces
        [ 6 ]  RENI M,DUGNANI E,CEREDA S,et al.(Ir)relevance    desmoplasia in pancreatic cancer by reprogramming stel-
             of metformin treatment in patients with metastatic pancre-  late cells and tumor-associated macrophages[J]. PLoS
             atic cancer:an open-label,randomized phase Ⅱ trial[J].  One,2015,10(12):e0141392.
             Clin Cancer Res,2016,22(5):1076-1085.         [20]  NIETO MA,HUANG RY,JACKSON RA,et al. EMT:
        [ 7 ]  KORDES S,POLLAK MN,ZWINDERMAN AH,et al.          2016[J]. Cell,2016,166(1):21-45.
             Metformin in patients with advanced pancreatic cancer:a  [21]  WANG Q,QU X. New insights into the roles of RGC-
             double-blind,randomised,placebo-controlled phase 2 tri-  32[J]. Cell Mol Immunol,2018,15(8):803-804.
             al[J]. Lancet Oncol,2015,16(7):839-847.       [22]  ZHU L,QIN H,ZHAO Q,et al. Response gene to comple-
        [ 8 ]  RHIM AD,MIREK ET,AIELLO NM,et al. EMT and dis-   ment-32 enhances metastatic phenotype by mediating
             semination precede pancreatic tumor formation[J]. Cell,  transforming growth factor beta-induced epithelial-mesen-
             2012,148(1/2):349-361.                             chymal transition in human pancreatic cancer cell line Bx-
        [ 9 ]  DERYNCK R,ZHANG YE. Smad-dependent and Smad-     PC-3[J]. J Exp Clin Cancer Res,2012. DOI:10.1186/
             independent pathways in TGF-beta family signalling[J].  1756-9966-31-29.
             Nature,2003,425(6958):577-584.                [23]  ZHU L,DING Y,ZHAO Q. Response gene to comple-
        [10]  LEVY L,HILL CS. Smad4 dependency defines two class-  ment-32 mediates TGF-beta-induced epithelial-mesenchy-
             es of transforming growth factor β(TGF-β)target genes  mal transition via Erk-p38-MAPK signaling pathways in
             and distinguishes TGF-β-induced epithelial-mesenchymal  human pancreatic cancer cell line BxPC-3[J]. Int J Clin
             transition from its antiproliferative and migratory respons-  Exp Pathol,2017,10(6):7135-7143.
             es[J]. Mol Cell Biol,2005,25(18):8108-8125.   [24]  ZHU L,ZHAO Q. Hypoxia-inducible factor I alpha partic-
        [11]  BARDEESY N,DEPINHO RA. Pancreatic cancer biolo-   ipates in hypoxia-induced epithelial-mesenchymal transi-
             gy and genetics[J]. Nat Rev Cancer,2002,2(12):897-  tion vis response gene to complement 32[J]. Exp Ther
             909.                                               Med,2017,14(2):1825-1831.
        [12]  WILENTZ RE,IACOBUZIO-DONAHUE CA,ARGANI       [25]  ZHU L,DING Y. RGC-32 induces transition of pancreatic
             P,et al. Loss of expression of DPC4 in pancreatic intraepi-  cancer to epithelial mesenchyme in vivo[J]. Pancreatolo-
             thelial neoplasia:evidence that DPC4 inactivation occurs  gy,2018,18(5):572-576.
             late in neoplastic progression[J]. Cancer Res,2000,60  [26]  CUI XB,LUAN JN,YE J,et al. RGC32 deficiency pro-
            (7):2002-2006.                                      tects against high-fat diet-induced obesity and insulin re-
        [13]  TONG D,LIU Q,LIU G,et al. Metformin inhibits castra-  sistance in mice[J]. J Endocrinol,2015,224(2):127-137.
             tion-induced EMT in prostate cancer by repressing COX2/  [27]  CUI XB,LUAN JN,CHEN SY. RGC-32 deficiency pro-
             PGE2/STAT3 axis[J]. Cancer Lett,2017. DOI:10.1016/j.  tects against hepatic steatosis by reducing lipogenesis[J]. J
             canlet.2016.12.031.                                Biol Chem,2015,290(33):20387-20395.
        [14]  KAMISAWA T,WOOD LD,ITOI T,et al. Pancreatic can-          (收稿日期:2019-05-14   修回日期:2019-10-19)
             cer[J]. Lancet,2016,388(10039):73-85.                                              (编辑:张元媛)








        中国药房    2020年第31卷第2期                                               China Pharmacy 2020 Vol. 31 No. 2  ·207  ·
   80   81   82   83   84   85   86   87   88   89   90