Page 157 - 2019年2月第30卷第4期
P. 157

Pharm Sci,2013,37(8):368-375.                       3-epi-betulinic acid derivatives as potent and selective
        [41]  LIU Z,SWIDORSKI JJ,NOWICKA-SANS B,et al. C-3       TGR5 agonists with improved cellular efficacy[J]. Acta
             benzoic acid derivatives of C-3 deoxybetulinic acid and  Pharmacol Sin,2014,35(11):1463-1472.
             deoxybetulin as HIV-1 maturation inhibitors[J]. Bioorg  [53]  XIE R,ZHANG H,WANG XZ,et al. The protective ef-
             Med Chem,2016,24(8):1757-1770.                      fect of betulinic acid(BA)diabetic nephropathy on strep-
        [42]  VISALLI RJ,ZIOBROWSKI H,BADRI KR,et al. Ionic      tozotocin(STZ)-induced diabetic rats[J]. Food Funct,
             derivatives of betulinic acid exhibit antiviral activity  2016,8(1):299-306.
             against herpes simplex virus type-2(HSV-2),but not  [54]  KIM J,LEE YS,KIM CS,et al. Betulinic acid has an in-
             HIV-1 reverse transcriptase[J]. Bioorg Med Chem Lett,  hibitory effect on pancreatic lipase and induces adipocyte
             2015,25(16):3168-3171.                              lipolysis[J]. Phytother Res,2012,26(7):1103-1106.
        [43]  BORI ID,HUNG HY,QIAN K,et al. Anti-AIDS agents  [55]  LEE WS,IM KR,PARK YD,et al. Human ACAT-1 and
             88.Anti-HIV conjugates of betulin and betulinic acid with  ACAT-2 inhibitory activities of pentacyclic triterpenes
             AZT prepared via click chemistry[J]. Tetrahedron Lett,  from the leaves of Lycopus lucidus TURCZ[J]. Biol
             2012,53(15):1987-1989.                              Pharm Bull,2006,29(2):382-384.
        [44]  NAVID MH,LASZCZYK-LAUER MN,REICHLING J,       [56]  BRUSOTTI G,MONTANARI R,CAPELLI D,et al. Bet-
             et al. Pentacyclic triterpenes in birch bark extract inhibit  ulinic acid is a PPAR γ antagonist that improves glucose
             early step of herpes simplex virus type 1 replication[J].  uptake,promotes osteogenesis and inhibits adipogenesis
             Phytomedicine,2014,21(11):1273-1280.                [J]. Sci Rep,2017,7(1):5777-5783.
        [45]  PAVLOVA NI,SAVINOVA OV,NIKOLAEVA SN,et al.    [57]  QUAN HY,KIM DY,KIM SJ,et al. Betulinic acid alle-
             Antiviral activity of betulin,betulinic and betulonic acids  viates non-alcoholic fatty liver by inhibiting SREBP1 acti-
             against some enveloped and non-enveloped viruses[J]. Fi-  vity via the AMPK-mTOR-SREBP signaling pathway
             toterapia,2003,74(5):489-492.                       [J]. Biochem Pharmacol,2013,85(9):1330-1340.
        [46]  SILVA FSG,OLIVEIRA PJ,DUARTE MF. Oleanolic,ur-  [58]  ZHU L,XIANGLIAN YI,ZHAO J,et al. Mechanism of
             solic,and betulinic acids as food supplements or pharma-  betulinic acid on oxidative stressed mice induced by dexa-
             ceutical agents for type 2 diabetes:promise or illusion?  methasone[J]. Chin J Anim Nutr,2018,30(3):1035-
             [J]. J Agric Food Chem,2016,64(15):2991-3008.       1043.
        [47]  KIM SJ,QUAN HY,JEONG KJ,et al. Beneficial effect  [59]  JIAO S,ZHU H,HE P,et al. Betulinic acid protects
             of betulinic acid on hyperglycemia via suppression of he-  against cerebral ischemia/reperfusion injury by activating
             patic glucose production[J]. J Agric Food Chem,2014,62  the PI3K/Akt signaling pathway[J]. Biomed Pharmaco-
             (2):434-442.                                        ther,2016. DOI:10.1016/j.biopha.2016.11.028.
        [48]  CASTRO AJ,FREDERICO MJ,CAZAROLLI LH,et al.    [60]  EKSIOGLU-DEMIRALP E,KARDAS ER,OZGUL S,et
             Betulinic acid and 1,25(OH) 2 vitamin D3 share intracellu-  al. Betulinic acid protects against ischemia/reperfusion-in-
             lar signal transduction in glucose homeostasis in soleus  duced renal damage and inhibits leukocyte apoptosis[J].
             muscle[J]. Int J Bio Chem Cell Biol,2014,48(1):18-27.  Phytother Res,2010,24(3):325-332.
        [49]  HEISS EH,KRAMER MP,ATANASOV AG,et al. Glyco-  [61]  KALRA J,LINGARAJU MC,MATHESH K,et al. Betu-
             lytic switch in response to betulinic acid in non-cancer  linic acid alleviates dextran sulfate sodium-induced colitis
             cells[J]. Plos One,2014,9(12):e115683.              and visceral pain in mice[J]. Naunyn Schmiedebergs Arch
        [50]  POLS TWH,NORIEGA LG,NOMURA M,et al. The bile       Pharmacol,2018,391(39):1-13.
             acid membrane receptor TGR5:a valuable metabolic target  [62]  NAVABI SP,SARKAKI A,MANSOURI E,et al. The ef-
             [J]. Dig Dis,2011,29(1):37-44.                      fects of betulinic acid on neurobehavioral activity,electro-
        [51]  LO SH,CHENG KC,LI YX,et al. Development of betu-   physiology and histological changes in an animal model
             linic acid as an agonist of TGR5 receptor using a new in  of the Alzheimer’s disease[J]. Behav Brain Res,2017.
             vitro assay[J]. Drug Des Devel Ther,2016. DOI:10.2147/  DOI:10.1016/j.bbr.2017.10.002.
             DDDT.S113197.                                               (收稿日期:2018-07-17  修回日期:2018-12-25)
        [52]  WANG XY,ZHANG SY,JING L,et al. Highly lipophilic                                   (编辑:段思怡)






        ·576  ·  China Pharmacy 2019 Vol. 30 No. 4                                   中国药房    2019年第30卷第4期
   152   153   154   155   156   157   158   159   160   161