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态;可通过多靶点协同作用发挥选择性抗肿瘤效应;可                           [10]  LIU C L,CHIU Y T,HU M L. Fucoxanthin enhances HO-1
          通过调控肠道菌群、β3ADR/UCP-1信号通路等发挥抗肥                           and NQO1 expression in murine hepatic BNL CL.2 cells
          胖作用。另外,岩藻黄素的特征性官能团具有良好的靶                                through activation of the Nrf2/ARE system partially by its
          点选择性和可逆抑制活性,是新型药物设计开发的                                  pro-oxidant  activity[J].  J  Agric  Food  Chem,2011,59
          模板。                                                    (20):11344-11351.
              目前,岩藻黄素在药理学、毒理学和药剂学领域已                         [11]  DING  R,ZHONG  S Y,DENG  L Y,et  al.  Fucoxanthin
                                                                  prevents lipopolysaccharide-induced acute lung injury by
          有相关研究文献发表,然而该成分的产业化、商业化开
                                                                  inhibiting  ferroptosis  via  Nrf2/STAT3  and  glutathione
          发仍处于起步阶段 ,这可能与岩藻黄素的性能研究不
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          足以及生产工艺开发中遇到的难题(如生产工艺成本
                                                             [12]  FILHO A  M,LAVERSANNE  M,FERLAY  J,et  al. The
          高、绿色可持续性低)有关。已有研究在硅藻中探索岩
                                                                  GLOBOCAN  2022  cancer  estimates:data  sources,me-
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          藻黄素的合成路径 ,未来或可通过生物合成技术,解
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          决岩藻黄素的生产难题。
                                                                  Int J Cancer,2025,156(7):1336-1346.
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          中国药房  2025年第36卷第17期                                              China Pharmacy  2025 Vol. 36  No. 17    · 2219 ·
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