Page 138 - 《中国药房》2025年7期
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adipocyte and lipid metabolism[J]. Food Funct,2020,11  lecular mechanisms of cell death:recommendations of the
              (1):483-492.                                         nomenclature committee on cell death 2018[J]. Cell Death
          [12]  BALKRISHNA A,GOHEL V,SINGH R,et al. Livogrit       Differ,2018,25(3):486-541.
               ameliorates acetaldehyde-induced steatosis in HepG2 cells   [25]  刘英琦,施喆,孙树刚,等. 澳洲茄碱通过MAPK/ERK信
               through modulation of lipogenesis and β-oxidation path‐  号通路调控肝癌细胞增殖、迁移和侵袭的研究[J]. 中国
               ways[J]. Phytomed Plus,2021,1(3):100067.            医院用药评价与分析,2023,23(2):182-186.
          [13]  CHOI J W,CHOI H J,RYU G H,et al. Inhibition of lipid   [26]  ZHU  L  N,LU  Y,SUN  Z,et  al.  The  application  of  an
               droplet accumulation by Solanum nigrum by suppressing   aqueous  two-phase  system  combined  with  ultrasonic  cell
               adipogenesis  and  inducing  lipolysis,thermogenesis  and   disruption extraction and HPLC in the simultaneous sepa‐
               autophagy  in  3T3-L1  cells[J].  Exp  Ther  Med,2023,26  ration and analysis of solanine and Solanum nigrum poly‐
              (1):333.                                             saccharide  from  Solanum  nigrum  unripe  fruit[J].  Food
          [14]  JAVED T,ASHFAQ U A,RIAZ S,et al. In-vitro antiviral   Chem,2020,304:125383.
               activity  of  Solanum  nigrum  against  Hepatitis  C  virus[J].   [27]  NAWAZ A,JAMAL A,ARIF A,et al. In vitro cytotoxic
               Virol J,2011,8:26.                                  potential  of  Solanum  nigrum  against  human  cancer  cell
          [15]  吴晶晶,张文娟,张骏鸿,等 . 澳洲茄边碱对人肝癌                          lines[J]. Saudi J Biol Sci,2021,28(8):4786-4792.
                                                              [28]  LIN  L  T,CHOONG  C Y,TAI  C  J.  Solanine  attenuates
               HepG2 细胞生长和凋亡的影响及机制初探[J]. 中国药
                                                                   hepatocarcinoma  migration  and  invasion  induced  by
               房,2021,32(24):2963-2969.
                                                                   acetylcholine[J]. Integr Cancer Ther,2020,19:15347354-
          [16]  刘良裕. 中药龙葵、白英的甾体生物碱类成分及抗肿瘤
                                                                   20909895.
               作用研究[D]. 北京:中国中医科学院,2022.
                                                              [29]  杨旭峰. 从调控TGF-β/Smads通路途径探讨龙葵防治肝
          [17]  LIU L Y,YANG Y K,WANG J N,et al. Steroidal alka‐
                                                                   癌的机理[J]. 陕西中医,2017,38(5):549-551.
               loids  from  Solanum  nigrum  and  their  cytotoxic  activities
                                                              [30]  YANG M Y,HUNG C H,CHANG C H,et al. Solanum
               [J]. Phytochemistry,2022,202:113317.
                                                                   nigrum  suppresses  angiogenesis-mediated  tumor  growth
          [18]  LUYEN B T T,TRANG B T T. New solasodine-type gly‐
                                                                   through  inhibition  of  the AKT/mTOR  pathway[J]. Am  J
               coalkaloids isolated from Solanum nigrum and their cyto‐
                                                                   Chin Med,2016,44(6):1273-1288.
               toxic  activity[J].  Chem  Biodivers,2024,21 (7) :
                                                              [31]  AKSHATHA G M,RAVAL S K,ARPITHA G M,et al.
               e202400872.
                                                                   Immunohistochemical,histopathological study and chemo‐
          [19]  姚譞 . 中药龙葵活性成分抗肿瘤药效及作用机制研究
                                                                   protective  effect  of  Solanum  nigrum  in  N-nitroso
               [D]. 上海:上海中医药大学,2020.
                                                                   diethylamine-induced  hepatocellular  carcinoma  in  Wistar
          [20]  NATH L R,GORANTLA J N,THULASIDASAN A K T,
                                                                   rats[J]. Vet World,2018,11(4):402-409.
               et al. Evaluation of uttroside B,a saponin from Solanum
                                                              [32]  高聚伟,徐凯,冉冉,等. 龙葵碱对肝癌Treg细胞介导的
               nigrum  Linn,as  a  promising  chemotherapeutic  agent
                                                                   肿瘤免疫逃逸的影响[J]. 中国现代医生,2021,59(18):
               against  hepatocellular  carcinoma[J].  Sci  Rep,2016,6:
                                                                   35-38,42,193.
               36318.
                                                              [33]  杨旭峰,温钱杏,张晶锐 . 龙葵片防治肝癌的临床研究
          [21]  NATH  L  R,SWETHA  M,VIJAYAKURUP  V,et  al.
                                                                   [J]. 中西医结合肝病杂志,2017,27(6):353-355.
               Blockade  of  uttroside  B-induced  autophagic  pro-survival
                                                              [34]  徐振杰,管静. 龙葵承气汤对肝癌介入术后患者并发症
               signals augments its chemotherapeutic efficacy against he‐
                                                                   及肝功能的影响[J]. 新中医,2015,47(8):207-209.
               patocellular carcinoma[J]. Front Oncol,2022,12:812598.  [35]  黄东彬,管静 . 龙葵承气汤对原发性肝癌患者 TACE 术
          [22]  KEERTHANA C K,AISWARYA S U,RAYGINIA T P,           后肝纤维化指标及免疫功能的影响[J]. 新中医,2016,48
               et al. A novel combinatorial regimen using sorafenib and   (5):211-213.
               uttroside B,a US FDA-designated ‘orphan drug’,for the   [36]  张玲,曾健,李军,等. 软肝化纤汤治疗慢性乙型肝炎肝
               treatment  of  hepatocellular  carcinoma[J].  Anticancer   纤维化患者 50 例临床观察[J]. 中华中医药杂志,2016,
               Agents Med Chem,2024,24(19):1431-1441.              31(12):5382-5385.
          [23]  WANG  H  C,CHUNG  P  J,WU  C  H,et  al.  Solanum          [37]  张团结. 软肝化纤汤联合恩替卡韦治疗慢性乙型肝炎后
               nigrum  L.  polyphenolic  extract  inhibits  hepatocarcinoma   肝纤维化(肝郁脾虚)随机平行对照研究[J]. 实用中医内
               cell growth by inducing G2/M phase arrest and apoptosis  科杂志,2019,33(4):32-35.
               [J]. J Sci Food Agric,2011,91(1):178-185.                    (收稿日期:2024-09-10  修回日期:2025-02-17)
          [24]  GALLUZZI L,VITALE I,AARONSON S A,et al. Mo‐                                       (编辑:胡晓霖)


          · 896 ·    China Pharmacy  2025 Vol. 36  No. 7                               中国药房  2025年第36卷第7期
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