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tion,suppression of cell migration and invasion and targe-   elephantopin induces apoptosis in HepG2 cells via oxida‐
               ting  Ras/Raf/MEK  signalling  pathway[J].  Acta  Biochim   tive stress,NF-κB inhibition and mitochondrial dysfunc‐
               Pol,2022,69(2):299-304.                             tion[J]. Biofactors,2017,43(1):63-72.
          [26]  GU W,ZHAO H,YUAN H,et al. Dehydrocostus lactone   [40]  BAI M,CHEN J J,XU W,et al. Germacranolides from
               reduced malignancy of HepG2 human hepatocellular car‐  Elephantopus  scaber  L.  and  their  cytotoxic  activities[J].
               cinoma cells via down-regulation of the PI3K/Akt signaling   Phytochemistry,2020,178:112479.
               pathway[J]. Bull Exp Biol Med,2023,174(3):360-364.  [41]  BAI M,CHEN J J,XU W,et al. Elephantopinolide A-P,
          [27]  SI H,BA G N,ZHUANG X J,et al. Dahuangwan targets   germacrane-type  sesquiterpene  lactones  from  Elephantopus
               EGF  signaling  to  inhibit  the  proliferation  of  hepatoma   scaber induce apoptosis,autophagy and G2/M phase arrest
               cells[J]. PLoS One,2020,15(4):e0231466.             in  hepatocellular  carcinoma  cells[J].  Eur  J  Med  Chem,
          [28]  MAO  J  X,YI  M,TAO Y Y,et  al.  Costunolide  isolated   2020,198:112362.
               from  Vladimiria  souliei  inhibits  the  proliferation  and  in‐  [42]  MEHMOOD T,MARYAM A,TIAN X G,et al. Santama‐
               duces  the  apoptosis  of  HepG2  cells[J].  Mol  Med  Rep,  rine inhibits NF-κB and STAT3 activation and induces
               2019,19(2):1372-1379.                               apoptosis in HepG2 liver cancer cells via oxidative stress
          [29]  CUI Y Q,LIU Y J,ZHANG F. The suppressive effects of   [J]. J Cancer,2017,8(18):3707-3717.
               Britannin (Bri)  on  human  liver  cancer  through  inducing   [43]  BAEK S Y,HWANG U W,SUK H Y,et al. Hemistepsin
               apoptosis  and  autophagy  via AMPK  activation  regulated   A  inhibits  cell  proliferation  and  induces  G0/G1-phase  ar‐
               by  ROS[J].  Biochem  Biophys  Res  Commun,2018,497  rest,cellular senescence and apoptosis via the AMPK and
              (3):916-923.                                         p53/p21  signals  in  human  hepatocellular  carcinoma[J].
                                                                   Biomolecules,2020,10(5):713.
          [30]  WANG B,ZHOU T Y,NIE C H,et al. Bigelovin,a sesqui‐
                                                              [44]  CHO I J,KIM J K,KIM E O,et al. Hemistepsin a induces
               terpene  lactone,suppresses  tumor  growth  through  indu-
                                                                   apoptosis of hepatocellular carcinoma cells by downregu‐
               cing apoptosis and autophagy via the inhibition of mTOR
               pathway  regulated  by  ROS  generation  in  liver  cancer[J].   lating STAT3[J]. Int J Mol Sci,2021,22(9):4743.
                                                              [45]  KUCK  K,JÜRGENLIEMK  G,LIPOWICZ  B,et  al.
               Biochem Biophys Res Commun,2018,499(2):156-163.
                                                                   Sesquiterpenes  from  myrrh  and  their  ICAM-1  inhibitory
          [31]  CHAI T,MENG X H,WANG C B,et al. Narjatamolide,
                                                                   activity in vitro[J]. Molecules,2020,26(1):42.
               an  unusual  homoguaiane  sesquiterpene  lactone  from
                                                              [46]  SU L H,MA W J,MA Y B,et al. Artemiprincepsolides A-
               Nardostachys jatamansi[J]. 2021,86(16):11006-11010.
                                                                   F,novel germacrane-guaiane and eudesmane-guaiane ses‐
          [32]  SHIMIZU Y,POLAVARAPU R,ESKLA K L,et al. Hy‐
                                                                   quiterpenoid  dimers  from  Artemisia  princeps  and  their
               drogen sulfide regulates cardiac mitochondrial biogenesis
                                                                   antihepatoma  activity[J].  Chin  J  Chem,2023,41(20):
               via the activation of AMPK[J]. J Mol Cell Cardiol,2018,
                                                                   2648-2656.
               116:29-40.
                                                              [47]  YAN Y,CHEN J,PENG M Y,et al. Sesquiterpenes from
          [33]  XU W H,GE K L,GUO Y L,et al. ROS-dependent cell
                                                                   Carpesium  faberi  triggered  ROS-induced  apoptosis  and
               death  induced  by  parthenolide  in  human  hepatoma  cell
                                                                   protective autophagy in hepatocellular carcinoma cells[J].
               HepG2[J]. OALib,2020,7(1):1-18.
                                                                   Phytochemistry,2023,214:113805.
          [34]  ZHANG Q,LU Y X,DING Y H,et al. Guaianolide ses‐  [48]  CHAN W K,TAN L T,CHAN K G,et al. Nerolidol:a ses‐
               quiterpene lactones,a source to discover agents that selec‐  quiterpene  alcohol  with  multi-faceted  pharmacological
               tively inhibit acute myelogenous leukemia stem and pro‐
                                                                   and biological activities[J]. Molecules,2016,21(5):529.
               genitor cells[J]. J Med Chem,2012,55(20):8757-8769.
                                                              [49]  BIAZI B I,ZANETTI T A,BARANOSKI A,et al. Cis-
          [35]  XU  Z  R,XU  J  Q,SUN  S  B,et  al.  Mecheliolide  elicits
                                                                   nerolidol  induces  endoplasmic  reticulum  stress  and  cell
               ROS-mediated  ERS  driven  immunogenic  cell  death  in      death  in  human  hepatocellular  carcinoma  cells  through
               hepatocellular carcinoma[J]. Redox Biol,2022,54:102351.  extensive  CYP2C19  and  CYP1A2  oxidation[J].  Basic
          [36]  AN Y H,GUO W J,LI L N,et al. Micheliolide derivative   Clin Pharmacol Toxicol,2017,121(4):334-341.
               DMAMCL inhibits glioma cell growth in vitro and in vivo  [50]  郭伟强,徐彬,孟启宇,等. 茅术醇通过下调SMMC-7721
               [J]. PLoS One,2015,10(2):e0116202.                  和 LM3 细胞中 MEK/ERK 和 NF-κB 通路对肝癌的抗肿
          [37]  YAO S N,YE J P,YIN M Q,et al. DMAMCL exerts anti‐  瘤作用[J].中国药理学与毒理学杂志,2018,32(4):282.
               tumor  effects  on  hepatocellular  carcinoma  both  in  vitro   GUO W Q,XU B,MENG Q Y,et al. Anti-tumor effect of
               and in vivo[J]. Cancer Lett,2020,483:87-97.         hinesol  on  liver  cancer  via  downregulating  MEK/ERK
          [38]  DIVYA  G  S,MANSOOR  K  P,RASHEED  S  P,et  al.    and NF-κB pathway in SMMC-7721 and LM3 cells[J].
               PPAR  gamma  agonists:an  effective  strategy  for  cancer   Chin J Pharmacol Toxicol,2018,32(4):282.
               treatment[J]. J Pharm Sci Innov,2013,2(5):1-3.               (收稿日期:2024-12-05  修回日期:2025-01-07)
          [39]  MEHMOOD T,MARYAM A,ZHANG H,et al. Deoxy‐                                          (编辑:舒安琴)


          · 384 ·    China Pharmacy  2025 Vol. 36  No. 3                               中国药房  2025年第36卷第3期
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