Page 136 - 《中国药房》2023年22期
P. 136

[54]
          究仍处于表型数据的高通量采集及初步分析阶段 ,后                                 23-26.
          续还需要扩大各类中药研究的覆盖程度、增加样本量、                            [10]  李先娜,董辉,孙晖. 代谢组学在中医药现代化研究中的
          结合临床病例与动物模型、排除其他影响因素、规范样                                 应用[J]. 中医药信息,2016,33(5):114-117.
          本采集处理等流程,开发更加先进、精确的检测技术和                                 LI X N,DONG H,SUN H. Application of metabonomics
                                                                   in  modernization  of  traditional  Chinese  medicine[J].  Inf
          数据分析方法,在非靶向筛选的基础上进行靶向验证,
                                                                   Tradit Chin Med,2016,33(5):114-117.
          同时结合基因组学、转录组学、蛋白质组学、微生物组学
                                                              [11]  TANG Q,CANG S,JIAO J,et al. Integrated study of me‐
          等其他组学,为中医药现代化研究提供重要的理论基础
                                                                   tabolomics and gut metabolic activity from ulcerative coli‐
          和新的研究思路、方法。
                                                                   tis to colorectal cancer:the combined action of disordered
          参考文献                                                     gut microbiota and linoleic acid metabolic pathway might
          [ 1 ]  ANANTHAKRISHNAN A N. Epidemiology and risk fac‐   fuel cancer[J]. J Chromatogr A,2020,1629:461503.
               tors for IBD[J]. Nat Rev Gastroenterol Hepatol,2015,12  [12]  COBURN L A,HORST S N,ALLAMAN M M,et al. L-
              (4):205-217.                                         arginine  availability  and  metabolism  is  altered  in  ulcera-
          [ 2 ]  UNGARO R,MEHANDRU S,ALLEN P B,et al. Ulcera-      tive  colitis[J].  Inflamm  Bowel  Dis,2016,22(8):1847-
               tive colitis[J]. Lancet,2017,389(10080):1756-1770.  1858.
          [ 3 ]  NG  S  C,SHI  H  Y,HAMIDI  N,et  al.  Worldwide  inci‐  [13]  耿曙光,袁代解,黄宗武,等. 基于气相色谱-质谱的大鼠
               dence  and  prevalence  of  inflammatory  bowel  disease  in   溃疡性结肠炎模型结肠组织代谢组学特征[J]. 广东医
               the 21st century:a systematic review of population-based   学,2016,37(8):1113-1117.
               studies[J]. Lancet,2017,390(10114):2769-2778.       GENG S G,YUAN D J,HUANG Z W,et al. Metabolo‐
          [ 4 ]  DU  L,HA C. Epidemiology and pathogenesis of ulcera-  mic  features  of  the  colon  tissue  in  ulcerative  colitis  rat
               tive colitis[J]. Gastroenterol Clin North Am,2020,49(4):  model  based  on  gas  chromatography-mass  spectrometry
               643-654.                                            [J]. Guangdong Med J,2016,37(8):1113-1117.
          [ 5 ]  RAMOS G P,PAPADAKIS K A. Mechanisms of disease:  [14]  OOI  M,NISHIUMI  S,YOSHIE  T,et  al.  GC/MS-based
               inflammatory bowel diseases[J]. Mayo Clin Proc,2019,94  profiling of amino acids and TCA cycle-related molecules
              (1):155-165.                                         in  ulcerative  colitis[J].  Inflamm  Res,2011,60(9):
          [ 6 ]  王春霞,葛俊李,李芳,等. 中药治疗溃疡性结肠炎作用                        831-840.
               及机制研究进展[J]. 中国实验方剂学杂志,2023,29(2):              [15]  KOLHO  K  L,PESSIA A,JAAKKOLA  T,et  al.  Faecal
               270-282.                                            and  serum  metabolomics  in  paediatric  inflammatory
               WANG C X,GE J L,LI F,et al. Effect and mechanism of   bowel disease[J]. J Crohns Colitis,2017,11(3):321-334.
               traditional  Chinese  medicine  in  treatment  of  ulcerative   [16]  SUN M L,DU B,SHI Y,et al. Combined signature of the
               colitis:a  review[J].  Chin  J  Exp  Tradit  Med  Formulae,  fecal microbiome and plasma metabolome in patients with
               2023,29(2):270-282.                                 ulcerative colitis[J]. Med Sci Monit,2019,25:3303-3315.
          [ 7 ]  艾永建,何梦崎,王一涛,等. 经典方药治疗溃疡性结肠                   [17]  方青,欧阳冬生. 氧化三甲胺与炎症性疾病[J]. 中国临床
               炎的研究进展[J]. 中国中药杂志,2022,47(21):5797-                 药理学与治疗学,2019,24(3):318-326.
               5805.                                               FANG Q,OUYANG D S. Trimethylamine N-oxide and in‐
               AI Y J,HE M Q,WANG Y T,et al. Review of classical   flammatory disease[J]. Chin J Clin Pharmacol Ther,2019,
               prescriptions in treatment of ulcerative colitis[J]. China J   24(3):318-326.
               Chin Mater Med,2022,47(21):5797-5805.          [18]  KESHTELI A H,VAN DEN BRAND F F,MADSEN K
          [ 8 ]  周琼阁,王凯,席作武,等. 基于肠道微环境探讨中医药                        L,et al. Dietary and metabolomic determinants of relapse
               防治溃疡性结肠炎的机制[J]. 中国实验方剂学杂志,                          in  ulcerative  colitis  patients:a  pilot  prospective  cohort
               2023,29(7):222-229.                                 study[J]. World J Gastroenterol,2017,23(21):3890-3899.
               ZHOU Q G,WANG K,XI Z W,et al. Mechanism of tradi‐  [19]  HISAMATSU T,ONO N,IMAIZUMI A,et al. Decreased
               tional Chinese medicine in prevention and treatment of ul‐  plasma  histidine  level  predicts  risk  of  relapse  in  patients
               cerative  colitis:based  on  intestinal  microenvironment[J].   with ulcerative colitis in remission[J]. PLoS One,2015,10
               Chin J Exp Tradit Med Formulae,2023,29(7):222-229.  (10):e0140716.
          [ 9 ]  赵正阳,王至婉. 以代谢组学技术为代表的系统生物学                    [20]  FRITSCH J,GARCES L,QUINTERO M A,et al. Low-
               技术在慢性阻塞性肺疾病研究中的运用[J]. 中华中医药                         fat,high-fiber  diet  reduces  markers  of  inflammation  and
               学刊,2022,40(12):23-26.                               dysbiosis and improves quality of life in patients with ul‐
               ZHAO Z Y,WANG Z W. Application of systems biology   cerative  colitis[J].  Clin  Gastroenterol  Hepatol,2021,19
               technology  represented  by  metabonomics  in  COPD  re‐  (6):1189-1199.e30.
               search[J].  Chin  Arch  Tradit  Chin  Med,2022,40(12):  [21]  DAI L,TANG Y J,ZHOU W J,et al. Gut microbiota and


          · 2814 ·    China Pharmacy  2023 Vol. 34  No. 22                            中国药房  2023年第34卷第22期
   131   132   133   134   135   136   137   138   139   140