Page 69 - 《中国药房》2023年6期

·药物经济学·

我国粤港澳大湾区流感疫苗经济学评价的系统分析
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胡明政 1， 2＊ ，王延赏 ，王 明 ，李文涛 ，朱大伟 ，何 平 （1.北京大学公共卫生学院，北京 100191；2.北京
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大学中国卫生发展研究中心，北京 100191）
中图分类号 R956 文献标志码 A 文章编号 1001-0408（2023）06-0699-05
DOI 10.6039/j.issn.1001-0408.2023.06.11

摘 要 目的 系统分析我国粤港澳大湾区流感疫苗卫生经济学评价的研究现状，为今后学者开展粤港澳大湾区流感疫苗经济性
评价提供方法学参考。方法 计算机检索PubMed、Embase等7个英文数据库和中国知网、万方数据等3个中文数据库，收集研究
地区为粤港澳大湾区的流感疫苗卫生经济学评价研究，检索时限为建库起至2022年6月30日。筛选文献、提取信息后，对纳入文
献的研究设计、评价方法、模型情况、经济学评价结果与结论进行描述性分析，并采用卫生经济研究质量评价工具对文献质量进行
评价。结果 共纳入12篇文献，其中7篇的研究地区为中国香港，6篇的目标群体为老年群体，5篇的研究角度为全社会角度，研究
时限从6个月到9年不等。有8篇文献采用了成本-效用分析法，仅有2篇使用了传染病模型。有8篇文献进行了敏感性分析，且大
部分文献同时进行了单因素敏感性分析和概率敏感性分析。有10篇文献的评价结果表明，（联合）接种疫苗或提高疫苗接种率的
方案更具经济性。12篇文献中，有4篇的质量评分＞75分，属于高质量研究。结论 尽管大部分的纳入研究都显示接种疫苗具有
经济性，但现有文献的质量有待提升。建议后续开展大湾区流感疫苗经济学评价时，可考虑增加针对我国澳门和广东省其他城市
的经济学评价，优先选用动态模型和本地居民的近期数据，并参考相关工具、指南，以提高研究设计的规范性和科学性。
关键词 粤港澳大湾区；流感疫苗；经济学评价；系统分析

Systematic review of the economic evaluation of influenza vaccines in the Guangdong-Hong Kong-Macao
Greater Bay Area
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HU Mingzheng ，WANG Yanshang ，WANG Ming ，LI Wentao ，ZHU Dawei ，HE Ping（1. School of Public
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Health， Peking University， Beijing 100191， China；2. China Center for Health Development Studies， Peking
University， Beijing 100191， China）
ABSTRACT OBJECTIVE To systematically analyze the status of health economic evaluation studies of influenza vaccination in
Guangdong-Hong Kong-Macao Greater Bay Area （GBA） of China， and to provide a methodological reference for future scholars to
carry out economic evaluations of influenza vaccine in GBA. METHODS Seven English databases such as PubMed and Embase
and three Chinese databases such as CNKI and Wanfang database were searched. The economic evaluation studies of influenza
vaccines with the study area of GBA were collected. The search time frame was from the inception to June 30， 2022. After
screening the literature and extracting key information， descriptive analysis was conducted on the study design， evaluation
methods， model settings， results and conclusions of these collected papers， and the quality of the papers was evaluated using
Quality of Health Economic Studies. RESULTS A total of 12 papers were included， of which 7 had a study region of Hong Kong
in China， 6 had an older target group， 5 had a society-wide perspective， and the study time frame ranged from 6 months to 9
years. Besides， 8 papers used cost-utility analysis， only 2 used an epidemic model； 8 papers conducted sensitivity analyses， and
most of them conducted both one-way sensitivity analysis and probabilistic sensitivity analysis. Moreover， the results of the
economic evaluation of 10 papers showed that （combined） vaccination or increased vaccination rates were more economical. In
addition， 4 of the 12 papers had a quality score＞75， which were considered high-quality studies. CONCLUSIONS Although most
of the included studies showed that vaccination was economical， the quality of the existing paper needed to be improved. It is
recommended that subsequent studies on the economic evaluation of influenza vaccines in GBA may consider adding economic
evaluations for Macau and other cities in Guangdong of China， prioritizing dynamic models and recent data from local residents，
and referring to relevant tools and guidelines to improve the
Δ 基金项目 国家社会科学基金重大项目（No.21&ZD187）
standardization and scientificity of the study design.
＊第一作者 硕士研究生。研究方向 ：卫生经济学。E-mail：
humingzheng@stu.pku.edu.cn KEYWORDS Guangdong-Hong Kong-Macao Greater Bay
# 通信作者 研究员，博士生导师，博士。研究方向：卫生经济与 Area； influenza vaccine； economic evaluation； systematic
政策。E-mail：phe@pku.edu.cn review

中国药房 2023年第34卷第6期 China Pharmacy 2023 Vol. 34 No. 6 · 699 ·