Page 97 - 2020年20期
P. 97
pathology[J]. J Psychiatry Neurosci,2013,38(1):6-23. rotenoid,attenuates β-amyloid oligomer-induced neurotox-
[ 3 ] WU XG,WANG SS,MIAO H,et al. Scutellaria barbata fla- icity possibly via regulating the PI3K/Akt and the ERK
vonoids alleviate memory deficits and neuronal injuries in- pathways in SH-SY5Y cells[J]. Oxid Med Cell Longev,
duced by composited A β in rats[J]. Behav Brain Funct, 2017. DOI:10.1155/2017/6792543.
2016. DOI:10.1186/s12993-016-0118-8. [16] MANTZAVINOSA V,ALEXIOU A. Biomarkers for Alz-
[ 4 ] LAMBERT MP,VELASCO PT,CHANG L,et al. Mono- heimer’s disease diagnosis[J]. Curr Alzheimer Rse,2017,
clonal antibodies that target pathological assemblies of 14(11):1149-1154.
Aβ[J]. J Neur,2007,100(1):23-35. [17] HARDY J,SELKOE DJ. The Amyloid hypothesis of Alz-
[ 5 ] SHEN WX,CHEN JH,LU JH,et al. TGF-β 1 protection heimer’s disease:progress and problems on the road to
against Aβ 1-42-induced neuroinflammation and neurodegen- therapeutics[J]. Science,2002,297(5580):353-356.
eration in rats[J]. Int J Mol Sci,2014,15(12):22092- [18] KARAKIDA F,IKEYA Y,TSUNAKAWA M,et al. Cere-
22108. bral protective and cognition-improving effects of sinapic
[ 6 ] PENG MY,LING XM,SONG RX,et al. Upregulation of acid in rodents[J]. Biol Pharm Bull,2007,30(3):514-
GLT-1 via PI3K/Akt pathway contributes to neuroprotec- 519 .
tion induced by dexmedetomidine[J]. Front Neurol,2019. [19] CHEN CY. Sinapic acid and its derivatives as medicine in
DOI:10.3389/fneur.2019.01041. oxidative stress-induced diseases and aging[J]. Oxid Med
[ 7 ] GHARBI SI,ZVELEBIL MJ,SHUTTLEWORTH SJ,et al. Cell Longev,2016. DOI:10.1155/2016/3571614.
Exploring the specificity of the PI3K family inhibitor [20] RYU JH,KIM SY,JANG CG,et al. Anxiolytic and memo-
LY294002[J]. Biochem J,2007,404(1):15-21. ry-improving composition causing no side effects compri-
[ 8 ] JIANG W,LUO T,LI S,et al. Quercetin protects against sing phenylpropanoid compounds including cinnamic
okadaic acid-induced injury via MAPK and PI3K/Akt/ acid,p-courmaric acid,caffeic acid,ferulic acid and
GSK3β signaling pathways in HT22 hippocampal neurons sinapic acid:Korea,KR740566-B1[P]. 2008-09-29.
[J]. PLoS One, 2016. DOI: 10.1371/journal.pone. [21] HOFMANN BT,JÜCKER M. Activation of PI3K/Akt sig-
0152371. naling by N-terminal SH2 domain mutants of the p85 α
[ 9 ] LAFERLA FM,TINKLE BT,BIEBERICH CJ,et al. The regulatory subunit of PI3K is enhanced by deletion of its
Alzheimer’s A beta peptide induces neurodegeneration C-terminal SH2 domain[J]. Cell Signal,2012,24(10):
and apoptotic cell death in transgenic mice[J]. Nat Genet, 1950-1954.
1995,9(1):21-30. [22] TATO I,BARTRONS R,VENTURA F,et al. Amino acids
[10] XIAN YF,LIN ZX,MAO QQ,et al. Isorhynchophylline activate mammalian target of rapamycin complex 2
protects PC12 cells against beta-amyloid-induced apopto- (mTORC2)via PI3K/Akt signaling[J]. J Biol Chem,
sis via PI3K/Akt signaling pathway[J]. Evid Base Comple- 2011,286(8):6128-6142.
ment Alternat Med,2013. DOI:10.1155/2013/163057. [23] GRIFFIN RJ,MOLONEY A,KELLIHER M,et al. Activa-
[11] KLYUBIN I,CULLEN WK,HU NW,et.al. Alzheimer’s tion of Akt /PKB,increased phosphorylation of Akt sub-
disease Aβ assemblies mediating rapid disruption of syn- strates and loss and altered distribution of Akt and PTEN
aptic plasticity and memory[J]. Mol Brain,2012. DOI: are features of Alzheimer’s disease pathology[J]. J Neuro-
10.1186/1756-6606-5-25. chem,2005,93(1):105-117.
[12] LEE HE,KIM DH,PARK SJ,et al. Neuroprotective effect [24] YAO YJ,WANG YM,KONG L,et al. Osthole decreases
of sinapic acid in a mouse model of amyloid β 1-42 protein- tau protein phosphorylation via PI3K/AKT/GSK-3β sig-
induced Alzheimer’s disease[J]. Pharmacol Biochem Be- naling pathway in Alzheimer’s disease[J]. Life Sci,2019,
hav,2012,103(2):260-266. 15(1):16-24.
[13] KIM DH,YOON BH,JUNG WY,et al. Sinapic acid atten- [25] NISBET RM,POLANCO JC,ITTNER LM,et al. Tau ag-
uates kainic acid-induced hippocampal neuronal damage gregation and its interplay with amyloid-β[J]. Acta Neuro-
in mice[J]. Neuropharmacology,2010,59(1/2):20-30. pathol,2014,129(2):207-220.
[14] SHAHMOHAMADY P,EIDI A,MORTAZAVI P,et al. [26] BAE IS,KIM SH. Sinapic acid promotes browning of 3T3-
Effect of sinapic acid on memory deficits and neuronal de- L1 adipocytes via p38 MAPK/CREB pathway[J]. Biomed
generation induced by intracerebroventricular administra- Res Int,2020. DOI:10.1155/2020/5753623.
tion of streptozotocin in rats[J]. Pol J Pathol,2018,69 (收稿日期:2020-04-04 修回日期:2020-08-04)
(3):266-277. (编辑:罗 瑞)
[15] LIN JJ,YU J,ZHAO JY,et al. Fucoxanthin,a marine ca-
中国药房 2020年第31卷第20期 China Pharmacy 2020 Vol. 31 No. 20 ·2523 ·