Page 79 - 《中国药房》2026年6期
P. 79
成分的安全性及体内过程;探寻其在慢性 ALD、非酒精 [10] DUNN W,SHAH V H. Pathogenesis of alcoholic liver
性脂肪肝等更多肝病模型中的保护效果及协同用药 disease[J]. Clin Liver Dis,2016,20(3):445-456.
潜力。 [11] YAN C Y,HU W T,TU J Q,et al. Pathogenic mecha‐
综上所述,23-乙酰泽泻醇B能够改善酒精急性暴露 nisms and regulatory factors involved in alcoholic liver
所引发的小鼠肝损伤,其机制可能与调控 Keap1/Nrf2/ disease[J]. J Transl Med,2023,21(1):300.
[12] 吴珍,魏瑶,杨玉姣,等. 23-乙酰泽泻醇B对肥胖模型小
NQO1信号通路以发挥抗氧化应激作用,同时改善肝脏
鼠糖脂代谢紊乱的改善作用[J]. 中国药房,2021,32(9):
脂质代谢有关。
1057-1062.
参考文献
[13] MENG Q,CHEN X L,WANG C Y,et al. Protective ef‐
[ 1 ] LAMAS-PAZ A,HAO F J,NELSON L J,et al. Alcoholic
fects of alisol B 23-acetate via farnesoid Ⅹ receptor-
liver disease:utility of animal models[J]. World J Gastro-
mediated regulation of transporters and enzymes in
enterol,2018,24(45):5063-5075.
estrogen-induced cholestatic liver injury in mice[J].
[ 2 ] HU Y,WANG S X,WU L,et al. Puerarin inhibits inflam‐
Pharm Res,2015,32(11):3688-3698.
mation and lipid accumulation in alcoholic liver disease
[14] 周慧雨,牛立云,刘慧蒙,等. 药食同源组合物对小鼠急
through regulating MMP8[J]. Chin J Nat Med,2023,21
性酒精性肝损伤保护作用研究[J]. 食品与发酵工业,
(9):670-681.
2023,49(20):259-264.
[ 3 ] ZHANG W J,SONG Q,BI X F,et al. Preparation of Puera-
[15] MALNICK S D H,ALIN P,SOMIN M,et al. Fatty liver
ria lobata root-derived exosome-like nanovesicles and
disease-alcoholic and non-alcoholic:similar but different
evaluation of their effects on mitigating alcoholic intoxica‐
[J]. Int J Mol Sci,2022,23(24):16226.
tion and promoting alcohol metabolism in mice[J]. Int J [16] 文永岚,王瑜,万科,等. 刺梨酵素化果醋对小鼠急性酒
Nanomedicine,2024,19:4907-4921.
精性肝损伤的改善作用[J]. 现代食品科技,2023,39(4):
[ 4 ] JUNG Y S,RADHAKRISHNAN K,HAMMAD S,et al. 26-32.
ERRγ -inducible FGF23 promotes alcoholic liver injury [17] WANG S S,SHENG F Y,ZOU L,et al. Hyperoside at‐
through enhancing CYP2E1 mediated hepatic oxidative
tenuates non-alcoholic fatty liver disease in rats via choles‐
stress[J]. Redox Biol,2024,71:103107. terol metabolism and bile acid metabolism[J]. J Adv Res,
[ 5 ] 张晓晶,武瑞,黄伟,等. 还原型谷胱甘肽联合多烯磷脂 2021,34:109-122.
酰胆碱治疗酒精性肝病临床疗效观察[J]. 中国卫生检验 [18] FU Y,FENG H,DING X,et al. Alisol B23-acetate adjusts
杂志,2022,32(21):2603-2605,2609. bile acid metabolism via hepatic FXR-BSEP signaling ac‐
[ 6 ] 戴梦翔,金姝娜,宋成武,等. 泽泻及其炮制品化学成分 tivation to alleviate atherosclerosis[J]. Phytomedicine,
和药理作用的研究进展[J]. 中草药,2023,54(5):1620- 2022,101:154120.
1635. [19] XIAO Z J,YU X F,ZHANG S,et al. The expression levels
[ 7 ] GALICIA-MORENO M,LUCANO-LANDEROS S, and significance of GSH,MDA,SOD,and 8-OHdG in
MONROY-RAMIREZ H C,et al. Roles of Nrf2 in liver osteochondral defects of rabbit knee joints[J]. Biomed Res
diseases:molecular,pharmacological, and epigenetic Int,2022,2022:6916179.
aspects[J]. Antioxidants (Basel),2020,9(10):980. [20] O’ROURKE S A,SHANLEY L C,DUNNE A. The Nrf2-
[ 8 ] SHARMA A,ANAND S K,SINGH N,et al. Berbamine HO-1 system and inflammaging[J]. Front Immunol,2024,
induced AMPK activation regulates mTOR/SREBP-1c 15:1457010.
axis and Nrf2/ARE pathway to allay lipid accumulation [21] 刘玲玲,张鲁宁,姜胜男,等. 基于Keap1/Nrf2/ARE信号
and oxidative stress in steatotic HepG2 cells[J]. Eur J 通路探讨丹皮酚改善酒精性肝、脑损伤小鼠氧化应激损
Pharmacol,2020,882:173244. 伤与炎症的作用机制[J]. 安徽中医药大学学报,2024,43
[ 9 ] 唐莹莹,贾夏丽,王金圆,等.23-乙酰泽泻醇B对千里光 (2):73-80.
碱致急性肝损伤小鼠水液失衡的影响[J]. 药学学报, (收稿日期:2025-11-10 修回日期:2026-02-28)
2024,59(7):1982-1992. (编辑:舒安琴)
中国药房 2026年第37卷第6期 China Pharmacy 2026 Vol. 37 No. 6 · 757 ·

