Page 79 - 《中国药房》2026年6期
P. 79

成分的安全性及体内过程;探寻其在慢性 ALD、非酒精                         [10]  DUNN  W,SHAH  V  H.  Pathogenesis  of  alcoholic  liver
          性脂肪肝等更多肝病模型中的保护效果及协同用药                                  disease[J]. Clin Liver Dis,2016,20(3):445-456.
          潜力。                                                [11]  YAN  C Y,HU  W  T,TU  J  Q,et  al.  Pathogenic  mecha‐
              综上所述,23-乙酰泽泻醇B能够改善酒精急性暴露                            nisms  and  regulatory  factors  involved  in  alcoholic  liver
          所引发的小鼠肝损伤,其机制可能与调控 Keap1/Nrf2/                          disease[J]. J Transl Med,2023,21(1):300.
                                                             [12]  吴珍,魏瑶,杨玉姣,等. 23-乙酰泽泻醇B对肥胖模型小
          NQO1信号通路以发挥抗氧化应激作用,同时改善肝脏
                                                                  鼠糖脂代谢紊乱的改善作用[J]. 中国药房,2021,32(9):
          脂质代谢有关。
                                                                  1057-1062.
          参考文献
                                                             [13]  MENG Q,CHEN X L,WANG C Y,et al. Protective ef‐
          [ 1 ]  LAMAS-PAZ A,HAO F J,NELSON L J,et al. Alcoholic
                                                                  fects  of  alisol  B  23-acetate  via  farnesoid  Ⅹ  receptor-
              liver disease:utility of animal models[J]. World J Gastro-
                                                                  mediated  regulation  of  transporters  and  enzymes  in
              enterol,2018,24(45):5063-5075.
                                                                  estrogen-induced  cholestatic  liver  injury  in  mice[J].
          [ 2 ]  HU Y,WANG S X,WU L,et al. Puerarin inhibits inflam‐
                                                                  Pharm Res,2015,32(11):3688-3698.
              mation  and  lipid  accumulation  in  alcoholic  liver  disease
                                                             [14]  周慧雨,牛立云,刘慧蒙,等. 药食同源组合物对小鼠急
              through  regulating  MMP8[J].  Chin  J  Nat  Med,2023,21
                                                                  性酒精性肝损伤保护作用研究[J]. 食品与发酵工业,
              (9):670-681.
                                                                  2023,49(20):259-264.
          [ 3 ]  ZHANG W J,SONG Q,BI X F,et al. Preparation of Puera-
                                                             [15]  MALNICK S D H,ALIN P,SOMIN M,et al. Fatty liver
              ria  lobata  root-derived  exosome-like  nanovesicles  and
                                                                  disease-alcoholic  and  non-alcoholic:similar  but  different
              evaluation of their effects on mitigating alcoholic intoxica‐
                                                                  [J]. Int J Mol Sci,2022,23(24):16226.
              tion  and  promoting  alcohol  metabolism  in  mice[J].  Int  J   [16]  文永岚,王瑜,万科,等. 刺梨酵素化果醋对小鼠急性酒
              Nanomedicine,2024,19:4907-4921.
                                                                  精性肝损伤的改善作用[J]. 现代食品科技,2023,39(4):
          [ 4 ]  JUNG Y S,RADHAKRISHNAN K,HAMMAD S,et al.         26-32.
              ERRγ -inducible  FGF23  promotes  alcoholic  liver  injury   [17]  WANG S S,SHENG F Y,ZOU L,et al. Hyperoside at‐
              through  enhancing  CYP2E1  mediated  hepatic  oxidative
                                                                  tenuates non-alcoholic fatty liver disease in rats via choles‐
              stress[J]. Redox Biol,2024,71:103107.               terol metabolism and bile acid metabolism[J]. J Adv Res,
          [ 5 ]  张晓晶,武瑞,黄伟,等. 还原型谷胱甘肽联合多烯磷脂                       2021,34:109-122.
              酰胆碱治疗酒精性肝病临床疗效观察[J]. 中国卫生检验                    [18]  FU Y,FENG H,DING X,et al. Alisol B23-acetate adjusts
              杂志,2022,32(21):2603-2605,2609.                      bile acid metabolism via hepatic FXR-BSEP signaling ac‐
          [ 6 ]  戴梦翔,金姝娜,宋成武,等. 泽泻及其炮制品化学成分                       tivation  to  alleviate  atherosclerosis[J].  Phytomedicine,
              和药理作用的研究进展[J]. 中草药,2023,54(5):1620-                 2022,101:154120.
              1635.                                          [19]  XIAO Z J,YU X F,ZHANG S,et al. The expression levels
          [ 7 ]  GALICIA-MORENO  M,LUCANO-LANDEROS  S,            and  significance  of  GSH,MDA,SOD,and  8-OHdG  in
              MONROY-RAMIREZ H C,et al. Roles of Nrf2 in liver    osteochondral defects of rabbit knee joints[J]. Biomed Res
              diseases:molecular,pharmacological,  and  epigenetic       Int,2022,2022:6916179.
              aspects[J]. Antioxidants (Basel),2020,9(10):980.  [20]  O’ROURKE S A,SHANLEY L C,DUNNE A. The Nrf2-
          [ 8 ]  SHARMA A,ANAND S K,SINGH N,et al. Berbamine      HO-1 system and inflammaging[J]. Front Immunol,2024,
              induced  AMPK  activation  regulates  mTOR/SREBP-1c   15:1457010.
              axis  and  Nrf2/ARE  pathway  to  allay  lipid  accumulation   [21]  刘玲玲,张鲁宁,姜胜男,等. 基于Keap1/Nrf2/ARE信号
              and  oxidative  stress  in  steatotic  HepG2  cells[J].  Eur  J   通路探讨丹皮酚改善酒精性肝、脑损伤小鼠氧化应激损
              Pharmacol,2020,882:173244.                          伤与炎症的作用机制[J]. 安徽中医药大学学报,2024,43
          [ 9 ]  唐莹莹,贾夏丽,王金圆,等.23-乙酰泽泻醇B对千里光                     (2):73-80.
              碱致急性肝损伤小鼠水液失衡的影响[J]. 药学学报,                                    (收稿日期:2025-11-10  修回日期:2026-02-28)
              2024,59(7):1982-1992.                                                               (编辑:舒安琴)









          中国药房  2026年第37卷第6期                                                 China Pharmacy  2026 Vol. 37  No. 6    · 757 ·
   74   75   76   77   78   79   80   81   82   83   84