Page 134 - 《中国药房》2026年6期

·综述·

中医药通过“脑-肠轴”干预胃食管反流病伴睡眠障碍的研究
进展
Δ

滕泽众 ，黎丽群 ，谭金晶 ，谢 胜 ，杨成宁（1.广西中医药大学研究生院，南宁 530023；2.广西中医药大学
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第一附属医院脾胃病科，南宁 530023；3.广西中医药大学第一附属医院临床试验机构办公室，南宁 530023；
4.广西中医药大学第一附属医院治未病中心，南宁 530023）
中图分类号 R285；R975+.1；R256.23 文献标志码 A 文章编号 1001-0408（2026）06-0812-05
DOI 10.6039/j.issn.1001-0408.2026.06.20

摘 要 胃食管反流病（GERD）与睡眠障碍的临床共病率高，二者通过“脑-肠轴”形成恶性循环，严重影响患者生活质量。中医药
以“整体观念”和“辨证论治”为核心指导，具有多靶点、低副作用的治疗特色，可为临床提供多元化的干预方案。本文从“脑-肠轴”
角度出发，通过综述GERD与睡眠障碍共病的关系、系统梳理中医药调控“脑-肠轴”干预该共病的相关研究发现，“脑-肠轴”可通
过脑肠肽（含胃肠分泌素）分泌异常、肠道菌群失调等途径，参与GERD伴睡眠障碍的病理过程；紧扣“肝胃不和”“胃不和则卧不
安”等核心病机，运用中药复方（四逆散合左金丸加减等）、中医外治疗法（背俞指针疗法等）及中西医结合治疗（加味柴胡桂枝干姜
汤联合质子泵抑制剂等）等多种手段，可靶向调节“脑-肠轴”相关神经递质、胃肠激素、炎症因子水平及肠道菌群组成，从而实现对
GERD与睡眠障碍的同步改善。
关键词 胃食管反流病；睡眠障碍；共病；脑-肠轴；中药复方；中医外治疗法；中西医结合治疗

Research progress on the intervention of gastroesophageal reflux disease with sleep disorders through the
“brain-gut axis” with traditional Chinese medicine
TENG Zezhong ，LI Liqun ，TAN Jinjing ，XIE Sheng ，YANG Chengning （1. Graduate School， Guangxi
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University of Chinese Medicine， Nanning 530023， China；2. Dept. of Spleen and Stomach Disease， the First
Affiliated Hospital of Guangxi University of Chinese Medicine， Nanning 530023， China；3. Office of Clinical
Trial Institution， the First Affiliated Hospital of Guangxi University of Chinese Medicine， Nanning 530023，
China；4. Preventive Treatment Center， the First Affiliated Hospital of Guangxi University of Chinese Medicine，
Nanning 530023， China）

ABSTRACT The comorbidity rate of gastroesophageal reflux disease （GERD） and sleep disorders is high， and the two form a
vicious circle through the “brain-gut axis”， which seriously impacts the patients’ quality of life. Traditional Chinese medicine
（TCM）， guided by the core principles of “holistic concept” and “syndrome differentiation and treatment”， features multi-targeted
therapeutic effects with minimal side effects， offering diverse intervention options for clinical practice. From the perspective of the
“brain-gut axis”， this article reviews the relationship between the comorbidity of GERD and sleep disorders and systematically
examines relevant research findings on how TCM regulates the “brain-gut axis” to intervene in this comorbid condition. The study
reveals that the “brain-gut axis” may participate in the pathological progress of GERD accompanied by sleep disorders through
pathways such as abnormalities in the secretion of brain-gut peptides （including gastrointestinal secretin）， as well as intestinal
dysbiosis. By closely focusing on core pathogenic mechanisms such as “disharmony between the liver and stomach” and “insomnia
due to stomach disharmony”， various approaches can be employed， including TCM formulas （e. g.， modified Sini powder
combined with Zuojin pills）， external TCM therapies （e.g.， back-shu point digital acupressure）， and integrated traditional Chinese
and Western medicine treatments （e.g.， modified Chaihu guizhi ganjiang decoction combined with proton pump inhibitors）. These
methods can regulate the levels of neurotransmitters， gastrointestinal hormones， inflammatory factors， and the composition of
intestinal microbiota associated with the “brain-gut axis”，
Δ 基金项目 国家自然科学基金项目（No.82360910）；广西自然科
thereby achieving simultaneous improvement in both GERD
学基金面上项目（No.2024GXNSFAA010291）；国家中医药管理局高水
and sleep disorders.
平中医药重点学科建设项目（No.zyyzdxk-2023167）
＊第一作者 硕士研究生。研究方向：中医防治脾胃相关疾病。 KEYWORDS gastroesophageal reflux disease； sleep disorders；
E-mail：908724948@qq.com comorbidity； brain-gut axis； TCM formula； external TCM
# 通信作者 副主任医师，硕士生导师。研究方向：中医防治脾胃 therapies； integrated traditional Chinese and Western medicine
相关疾病。E-mail：1730397922@qq.com treatments

· 812 · China Pharmacy 2026 Vol. 37 No. 6 中国药房 2026年第37卷第6期