Page 132 - 《中国药房》2020年22期
P. 132
related CpG island methylation in ulcerative colitis[J]. specific histone acetylation and deacetylation[J]. Annu
Cancer Res,2001,61(9):3573-3577. Rev Biochem,2007,76(1):75-100.
[11] EMMETT RA,DAVIDSON KL,GOULD NJ,et al. DNA [24] SACCANI S. Dynamic changes in histone H3 Lys 9 meth-
methylation patterns in ulcerative colitis-associated can- ylation occurring at tightly regulated inducible inflamma-
cer:a systematic review[J]. Epigenomics,2017,9(7): tory genes[J]. Genes Dev,2002,16(17):2219-2224.
1029-1042. [25] CHOUDHARY C,KUMAR C,GNAD F,et al. Lysine
[12] SAITO S,KATO J,HIRAOKA S,et al. DNA methylation acetylation targets protein complexes and co-regulates ma-
of colon mucosa in ulcerative colitis patients:correlation jor cellular functions[J]. Science,2009,325(5942):834-
with inflammatory status[J]. Inflamm Bowel Dis,2011,17 840.
(9):1955-1965. [26] REICHERT N,CHOUKRALLAH MA,MATTHIAS P.
[13] LIN Z,HEGARTY JP,YU W,et al. Identification of dis- Multiple roles of class Ⅰ HDACs in proliferation,differ-
ease-associated DNA methylation in B cells from Crohn’s entiation,and development[J]. Cell Mol Life Sci,2012,69
disease and ulcerative colitis patients[J]. Dig Dis Sci, (13):2173-2187.
2012,57(12):3145-3153. [27] FELICE C,LEWIS A,ARMUZZI A,et al. Review article:
[14] NIMMO ER,PRENDERGAST JG,ALDHOUS MC,et al. selective histone deacetylase isoforms as potential thera-
Genome-wide methylation profiling in Crohn’s disease peutic targets in inflammatory bowel diseases[J]. Aliment
identifies altered epigenetic regulation of key host defense Pharmacol Ther,2015,41(1):26-38.
mechanisms including the Th17 pathway[J]. Inflamm Bow- [28] CANTLEY MD,HAYNES DR. Epigenetic regulation of
el Dis,2012,18(5):889-899. inflammation:progressing from broad acting histone
[15] ZHAO H,NING S,NOLLEY R,et al. The immunomodu- deacetylase (HDAC) inhibitors to targeting specific
latory anticancer agent,RRx-001,induces an interferon re- HDACs[J]. Inflammopharmacology,2013,21(4):301-
sponse through epigenetic induction of viral mimicry[J]. 307.
Clin Epigenetics,2017. DOI:10.1186/s13148-017-0312-z. [29] DEKKER FJ,VAN DEN BOSCH T,MARTIN NI. Small
[16] NIELSEN SN,GRELL K,NERSTING J,et al. DNA-thio- molecule inhibitors of histone acetyltransferases and
guanine nucleotide concentration and relapse-free survival deacetylases are potential drugs for inflammatory diseas-
during maintenance therapy of childhood acute lympho- es[J]. Drug Discov Today,2014,19(5):654-660.
blastic leukaemia(NOPHO ALL2008):a prospective sub- [30] TAO R,DE ZOETEN EF,OZKAYNAK E,et al. Deacety-
study of a phase 3 trial[J]. Lancet Oncol,2017,18(4): lase inhibition promotes the generation and function of
515-524. regulatory T cells[J]. Nat Med,2007,13(11):1299-1307.
[17] DE BOER NK,VAN BODEGRAVEN AA,JHARAP B, [31] GLAUBEN R,SIEGMUND B. Inhibition of histone dea-
et al. Drug insight:pharmacology and toxicity of thiopu- cetylases in inflammatory bowel diseases[J]. Mol Med,
rine therapy in patients with IBD[J]. Nat Clin Pract Gas- 2011,17(5/6):426-433.
troenterol Hepatol,2007,4(12):686-694. [32] GLAUBEN R,BATRA A,FEDKE I,et al. Histone hyper-
[18] YIANNAKOPOULOU EC. Targeting DNA methylation acetylation is associated with amelioration of experimen-
with green tea catechins[J]. Pharmacology,2015,95(3/ tal colitis in mice[J]. J Immunol,2006,176(8):5015-
4):111-116. 5022.
[19] DU Y,DING H,VANARSA K,et al. Low dose epigallo- [33] GLAUBEN R,BATRA A,STROH T,et al. Histone dea-
catechin gallate alleviates experimental colitis by subdu- cetylases:novel targets for prevention of colitis-associated
ing inflammatory cells and cytokines,and improving intes- cancer in mice[J]. Gut,2008,57(5):613-622.
tinal permeability[J]. Nutrients,2019. DOI:10.3390/nu [34] LEE JW,LEE SM,CHUN J,et al. Novel histone deacety-
11081743. lase 6 Inhibitor CKD-506 Inhibits NF-kappaB signaling in
[20] LIU Z,XIE Z,JONES W,et al. Curcumin is a potent intestinal epithelial cells and macrophages and amelio-
DNA hypomethylation agent[J]. Bioorg Med Chem Lett, rates acute and chronic murine colitis[J]. Inflamm Bowel
2009,19(3):706-709. Dis,2020,26(6):852-862.
[21] BURGE K,GUNASEKARAN A,ECKERT J,et al. Cur- [35] YAMAGISHI M,UCHIMARU K. Targeting EZH2 in can-
cumin and intestinal inflammatory diseases:molecular cer therapy[J]. Curr Opin Oncol,2017. DOI:10.1097/
mechanisms of protection[J]. Int J Mol Sci,2019. DOI: COO.0000000000000390.
10.3390/ijms20081912. [36] ZHOU J,HUANG S,WANG Z,et al. Targeting EZH2 his-
[22] KOUZARIDES T. Chromatin modifications and their tone methyltransferase activity alleviates experimental in-
function[J]. Cell,2007,128(4):693-705. testinal inflammation[J]. Nat Commun,2019. DOI:10.1038/
[23] SHAHBAZIAN MD,GRUNSTEIN M. Functions of site- s41467-019-10176-2.
·2810 · China Pharmacy 2020 Vol. 31 No. 22 中国药房 2020年第31卷第22期